Hostname: page-component-745bb68f8f-b95js Total loading time: 0 Render date: 2025-01-14T19:41:18.540Z Has data issue: false hasContentIssue false
  • English
  • Français

T2 and DWI in Pilocytic and Pilomyxoid Astrocytoma with Pathologic Correlation

Published online by Cambridge University Press:  02 December 2014

M. Horger ,
M. N. Vogel ,
R. Beschorner ,
U. Ernemann ,
J. Wörner ,
M. Fenchel ,
F. Ebner ,
T. Nägele  and
S. Heckl
M. Horger
Affiliation:
Department of Diagnostic and Interventional Radiology, Eberhard-Karls-University, Tübingen
M. N. Vogel*
Affiliation:
Department of Diagnostic and Interventional Radiology, Eberhard-Karls-University, Tübingen Department of Neuroradiology, University of Heidelberg, Heidelberg, Germany
R. Beschorner
Affiliation:
Institute for Brain Research, Eberhard-Karls-University, Tübingen
U. Ernemann
Affiliation:
Department of Diagnostic and Interventional Neuroradiology, Eberhard-Karls-University, Tübingen
J. Wörner
Affiliation:
Department of Diagnostic and Interventional Radiology, Eberhard-Karls-University, Tübingen
M. Fenchel
Affiliation:
Department of Diagnostic and Interventional Neuroradiology, Eberhard-Karls-University, Tübingen
F. Ebner
Affiliation:
Department of Neurosurgery, Eberhard-Karls-University, Tübingen
T. Nägele
Affiliation:
Department of Diagnostic and Interventional Neuroradiology, Eberhard-Karls-University, Tübingen
S. Heckl
Affiliation:
Department of Diagnostic and Interventional Neuroradiology, Eberhard-Karls-University, Tübingen
*
Department of Neuroradiology, University of Heidelberg, Heidelberg, Germany. Email: m.n.a.vogel@web.de
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Objective:

To quantify and compare T2 signal and apparent diffusion coefficient (ADC) in pilocytic and pilomyxoid astrocytoma (PA and PMA) and correlate results with myxoid content.

Methods:

Echo-planar diffusion weighted images (DWI) and standard magnetic resonance imaging (MRI) findings were reviewed retrospectively in patients with PA (n=34) and PMA (n=8). Regions of interest (ROIs) were drawn on ADC maps within tumor parts with lowest ADC values. Apparent diffusion coefficient values in tumor were normalized to those in cerebrospinal fluid (ADC/CSF). The ratio of T2 signal intensity in solid tumor parts to CSF (T2/CSF) was registered. Myxoid matrix was histologically quantified retrospectively in 8 PMAs and 17 PAs and correlated with imaging findings.

Results:

Mean ADC/CSF for PA and PMA was 0.53±0.10 and 0.69±0.10 (p<0.01). Mean T2/CSF for PA and PMA was 0.78±0.19 and 0.93±0.09 (p<0.01). Mean proportion of myxoid tumor matrix in PA was 50% (range, 10-100%) and 93% (range, 90-100%) in PMA (p=0.004). Eight patients (32%; all PA) had less than 50% myxoid content and 17 (68%; 8 PA; 9 PMA) had more. There was positive correlation of ADC/CSF, T2/CSF and ADC (r2=0.61, 0.65 and 0.60 respectively) and significant difference between the groups with more and less than 50% myxoid content (p=0.01 for ADC/CSF and T2/CSF and p=0.02 for ADC).

Conclusions:

General imaging features of PA and PMA are non-specific, ADC values and T2 signal intensity are generally higher in the latter, reflecting the proportion of myxoid matrix in these tumors.

Type
Original Article
Information
Canadian Journal of Neurological Sciences , Volume 39 , Issue 4 , July 2012 , pp. 491 - 498
Copyright
Copyright © The Canadian Journal of Neurological 2012

References

1.Fuller, C, Narendra, S.Pilocytic astrocytoma and pilomyxoid astrocytoma. In: Adesina, AM, Tihan, T, Young Pouissant, T, editors. Atlas of pediatric brain tumors (Pt 1). New York: Dordrecht, Heidelberg, London; Springer; 2010. p. 5–17.Google Scholar
2.Lee, YY, Van Tassel, P, Bruner, JM, Moser, RP, Share, JC.Juvenile pilocytic astrocytomas: CT and MR characteristics. Am J Roentgenol. 1989;152:1263–70.Google Scholar
3.Scheithauer, BW, Hawkins, C, Tihan, T, Van den Berg, SR, Burger, PC.Pilocytic astrocytoma. In: Louis, DN, Ohgaki, H, Wiestler, OD, Cavenee, WK, editors WHO Classification of tumours of the central nervous system. 4th ed. Lyon, France: IARC Press; 2007. p. 14–21.Google Scholar
4.Arslanoglu, A, Cirak, B, Horska, A, et al.MR imaging characteristics of pilomyxoid astrocytomas. Am J Neuroradiol. 2003;24:1906–8.Google Scholar
5.Linscott, LL, Osborn, AG, Blaser, S, et al.Pilomyxoid astrocytoma: expanding the imaging spectrum. Am J Neuroradiol. 2008;29:1861–6.Google Scholar
6.Lee, IH, Kim, JH, Suh, YL, et al.Imaging characteristics of pilomyxoid astrocytomas in comparison with pilocytic astrocytomas. Eur J Radiol. 2011;79(2):311–16.Google Scholar
7.Krabbe, K, Gideon, P, Wagn, P, Hansen, U, Thomsen, C, Madsen, F.MR diffusion imaging of human intracranial tumours. Neuroradiology. 1997;39:483–9.CrossRefGoogle ScholarPubMed
8.Sugahara, T, Korogi, Y, Kochi, M, et al.Usefulness of diffusion-weighted MRI with echo-planar technique in the evaluation of cellularity in gliomas. J Magn Reson Imaging. 1999;9:53–60.Google Scholar
9.Komotar, RJ, Zacharia, BE, Sughrue, ME, et al.Magnetic resonance imaging characteristics of pilomyxoid astrocytoma. Neurol Res. 2008;30(9):945–51.Google Scholar
10.Toh, CH, Castillo, M, Wong, AMC, et al.Primary cerebral lymphoma and glioblastoma multiforme: differences in diffusion characteristics evaluated with diffusion tensor imaging. Am J Neuroradiol. 2008;29:471–5.Google Scholar
11.Tihan, T, Fisher, PG, Kepner, JL, et al.Pediatric astrocytomas with monomorphous pilomyxoid features and a less favorable outcome. J Neuropathol Exp Neurol. 1999;58(10):1061–8.Google Scholar
12.Rumboldt, Z, Camacho, DL, Lake, D, Welsh, CT, Castillo, M.Apparent diffusion coefficients for differentiation of cerebellar tumors in children. Am J Neuroradiol. 2006;27(6):1362–9.Google Scholar
13.Lee, CS, Huh, JS, Sim, KB, Kim, YW.Cerebellar pilocytic astrocytoma presenting with intratumor bleeding, subarachnoid hemorrhage, and subdural hematoma. Childs Nerv Syst. 2009;25(1):125–8.Google Scholar