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The Treatment of the Restless Legs Syndrome with Clonazepam: A Prospective Controlled Study

Published online by Cambridge University Press:  18 September 2015

Dan Boghen ,
Lise Lamothe ,
Robert Elie ,
Roger Godbout  and
Jacques Montplaisir
Dan Boghen*
Affiliation:
The Neurology Service, Montréal, and the Faculty of Medicine, Université de Montréal, Montréal, Québec
Lise Lamothe
Affiliation:
Department of Pharmacy, Montréal, and the Faculty of Medicine, Université de Montréal, Montréal, Québec
Robert Elie
Affiliation:
Hôtel-Dieu de Montréal, The Louis-H. Lafontaine Hospital, Montréal, and the Faculty of Medicine, Université de Montréal, Montréal, Québec
Roger Godbout
Affiliation:
The Sleep Disorders Center, Sacré-Coeur Hospital, Montréal, and the Faculty of Medicine, Université de, Montréal, Québec
Jacques Montplaisir
Affiliation:
The Sleep Disorders Center, Sacré-Coeur Hospital, Montréal, and the Faculty of Medicine, Université de, Montréal, Québec
*
Neurology Service, Hôtel-Dieu de Montréal, 3840 St Urbain, Montréal, Québec H2W 1T8
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Abstract:

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The effect of clonazepam on the restless legs syndrome was studied in a group of 6 patients. Following a drug-free period, 3 patients received clonazepam for 4 weeks followed by placebo for 4 weeks thereafter and 3 patients received the same medication and for the same length of time but in reverse order. The effectiveness of the medication was evaluated by means of a self-rating system in which patients assigned a score daily to the degree of discomfort experienced in the previous 24 hours. Three patients improved on clonazepam but 2 of these also improved on placebo. Clonazepam was not shown to be significantly more effective than placebo in the treatment of RLS.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 13 , Issue 3 , August 1986 , pp. 245 - 247
Copyright
Copyright © Canadian Neurological Sciences Federation 1986

References

1.Boghen, D, Peyronnard, JM.Myoclonus in familial restless legs syndrome. Arch Neurol 1976; 33: 368–370.CrossRefGoogle ScholarPubMed
2.Cirignolta, F, Zucconi, M, Mondini, S, et al. Epidemiological data on sleep disorders. Abstr6th European Congress of Sleep Research. Zurich, March 23–26, 1982: 211.Google Scholar
3.Lundvall, O, Abom, P-E, Holm, R.Carbamazepine in the restless legs syndrome. A controlled pilot study. Eur J Clin Pharmacol 1983: 25: 324–324.CrossRefGoogle ScholarPubMed
4.Telstad, W, Sorensen, O, Larsen, S, Lillevold, PE.Stensrud, P.Nyberg-Hansen, R.Treatment of the restless legs syndrome with carbamazepine: a double blind study. BMJ 1984: 288: 443–446.CrossRefGoogle ScholarPubMed
5.Hening, W, Walters, A, Côté, L, Fahn, S.Opiate response myoclonus. Ann Neurol 1983; 14: 112 Abstract.Google Scholar
6.Trzepacs, PT, Violette, EJ, Sateia, MJ.Response to opioids in three patients with restless legs syndrome. Am J Psych 1984; 141: 993–995.Google Scholar
7.Matthews, WB.Treatment of restless legs syndrome with clonazepam. Br Med J 1979: 1: 751.CrossRefGoogle ScholarPubMed
8.Boghen, D.Successful treatment of restless legs with clonazepam. Ann Neurol 1980: 8: 341.CrossRefGoogle ScholarPubMed
9.Read, DJ, Feest, TG, Nassim, MA.Clonazepam: effective treatment for restless legs syndrome in uraemia. Br Med J 1981: 283: 855–886.CrossRefGoogle ScholarPubMed
10.Montagna, P, De Bianchi, LS, Fucconi, M, Cirignotta, F, Lugaresi, E.Clonazepam and vibration in restless legs syndrome. Acta Neurol Scand 1984; 69: 428–430.CrossRefGoogle ScholarPubMed
11.Hussey, HH.Restless legs syndrome. JAMA 1976: 235: 2224.CrossRefGoogle ScholarPubMed
12.Guilleminault, C, Flagg, W.Effect of baclofen on sleep-related periodic leg movements. Ann Neurol 1984: 15: 234–239.CrossRefGoogle ScholarPubMed