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Tuberous Sclerosis in an Infant of 28 Weeks Gestational Age

Published online by Cambridge University Press:  18 September 2015

Daniel Sharp  and
David M. Robertson
Daniel Sharp
Affiliation:
Department of Pathology (Neuropathology), Queen’s University and Kingston General Hospital, Kingston, Ontario
David M. Robertson*
Affiliation:
Department of Pathology (Neuropathology), Queen’s University and Kingston General Hospital, Kingston, Ontario
*
Department of Pathology, Queen’s University, Kingston, Ontario K7L 3N6.
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Summary:

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A case of tuberous sclerosis diagnosed at autopsy in a neonate at 28 weeks gestation is described. This is believed to be the earliest case yet reported. The CNS lesions consist of cortical tuberosities, heterotopic white matter nodules and subependymal nodules. These nodules consist predominantly of giant astrocytes but a small undifferentiated cell component is present as well. Multiple cardiac rhabdomyomas are also present. An explanation for neuronal hypocellularity within the cortical tuberosities is suggested.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 10 , Issue 1 , February 1983 , pp. 59 - 62
Copyright
Copyright © Canadian Neurological Sciences Federation 1983

References

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