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Variations in 5-HT2A Influence Spatial Cognitive Abilities and Working Memory

Published online by Cambridge University Press:  02 December 2014

Pingyuan Gong ,
Jing Li ,
Jian Wang ,
Xu Lei ,
Dongmei Chen ,
Kejin Zhang ,
Wenjiang Zhang ,
Anyuan Zhen ,
Xiaocai Gao  and
Fuchang Zhang
Pingyuan Gong
Affiliation:
Key Laboratory of Resource Biology and Biotechnology in Western China (Ministry of Education), College of Life Science, Institute of Population and Health College of Medicine, Henan University of Science and Technology, Luoyang, China
Jing Li
Affiliation:
Key Laboratory of Resource Biology and Biotechnology in Western China (Ministry of Education), College of Life Science, Institute of Population and Health College of Public Management, Institute of Application Psychology, Northwest University, Xi'an
Jian Wang
Affiliation:
Key Laboratory of Resource Biology and Biotechnology in Western China (Ministry of Education), College of Life Science, Institute of Population and Health College of Public Management, Institute of Application Psychology, Northwest University, Xi'an
Xu Lei
Affiliation:
Key Laboratory of Resource Biology and Biotechnology in Western China (Ministry of Education), College of Life Science, Institute of Population and Health
Dongmei Chen
Affiliation:
Key Laboratory of Resource Biology and Biotechnology in Western China (Ministry of Education), College of Life Science, Institute of Population and Health
Kejin Zhang
Affiliation:
Key Laboratory of Resource Biology and Biotechnology in Western China (Ministry of Education), College of Life Science, Institute of Population and Health
Wenjiang Zhang
Affiliation:
College of Public Management, Institute of Application Psychology, Northwest University, Xi'an
Anyuan Zhen
Affiliation:
College of Public Management, Institute of Application Psychology, Northwest University, Xi'an
Xiaocai Gao
Affiliation:
Key Laboratory of Resource Biology and Biotechnology in Western China (Ministry of Education), College of Life Science, Institute of Population and Health College of Public Management, Institute of Application Psychology, Northwest University, Xi'an
Fuchang Zhang*
Affiliation:
Key Laboratory of Resource Biology and Biotechnology in Western China (Ministry of Education), College of Life Science, Institute of Population and Health College of Public Management, Institute of Application Psychology, Northwest University, Xi'an
*
School of Life Science, Northwest University, 229 Tai Bai Road, Xi'an 710069, China
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Abstract

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Background:

5-hydroxytryptamine receptor 2A (5-HT2A) participates in diverse psychiatric disorders by regulating the activity of serotonin. Some previous studies have also suggested that the receptor is involved in cognitive abilities of disease groups. We hypothesize that some functional genetic variants in 5-HT2A have certain specific influences on cognitive abilities in a normal population.

Method:

To confirm this hypothesis, two polymorphisms (rs6313 and rs4941573) in 5-HT2A were selected, and a population-based study was performed in a young healthy Chinese Han cohort.

Results:

The results indicated that the rs6313 and rs4941573 were associated with touching blocks and mental rotation-3D error ratio in males, and the rs4941573 was associated with visuo-spatial working memory in the whole cohort.

Conclusion:

All the findings suggest that 5-HT2A participates in human spatial cognitive abilities and spatial working memory.

Type
Original Article
Information
Canadian Journal of Neurological Sciences , Volume 38 , Issue 2 , March 2011 , pp. 303 - 308
Copyright
Copyright © The Canadian Journal of Neurological 2011

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