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Le dividende de la longévité : Pourquoi investir dans la recherche fondamentale?

Published online by Cambridge University Press:  01 December 2009

Huber R. Warner  and
Felipe Sierra
Huber R. Warner*
Affiliation:
College of Biological Sciences, University of Minnesota
Felipe Sierra
Affiliation:
Division of Aging Biology, National Institute on Aging
*
*La correspondance et les demandes de tirés-à-part doivent être adressées à : / Correspondence and requests for offprints should be sent to: Huber R. Warner, Ph.D. Associate Dean for Research University of Minnesota College of Biological Sciences St. Paul, MN 55108 (warne033@umn.edu)
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Abstract

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Type
Canadian Institutes of Health Research–Institute of Aging: Profiles/Instituts canadiens de recherche en santé du Canada–Institut du vieillissement : Profils
Information
Canadian Journal on Aging / La Revue canadienne du vieillissement , Volume 28 , Issue 4 , December 2009 , pp. 395 - 398
Copyright
Copyright © Canadian Association on Gerontology 2009

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References

Berzlanovich, A.M., Keil, W., Waldhoer, T., Sim, E., Fasching, P. et Fazeny-Dorner, B. (2005). Do centenarians die healthy? An autopsy study. Journal of Gerontology: Medical Sciences, 60A, 862–865.Google Scholar
Butler, R.N., et Brody, J.A. (Eds.). (1995). Delaying the onset of late-life dysfunction. New York: Springer Publishing.Google Scholar
Colman, R.J., Anderson, R.M., Johnson, S.C., Kastman, E.K., Kosmatka, K.J., Beasley, T.M., et al. . (2009). Caloric restriction delays disease onset and mortality in rhesus monkeys. Science, 325, 201–204.CrossRefGoogle ScholarPubMed
Gruenberg, E.M. (1977). The failures of success. Milbank Memorial Fund Quarterly, 55, 3–24.CrossRefGoogle ScholarPubMed
Harrison, D.E., Strong, R., Sharp, Z.D., Nelson, J.F., Astle, C.M., Flurkey, K., et al. . (2009). Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature (in press).CrossRefGoogle ScholarPubMed
Heilbronn, L.K., de Jonge, L., Frisard, M.I., DeLaney, J.P., Larson-Meyer, D.E., Rood, J., et al. . (2006). Effect of 6-month calorie restriction on biomarkers of longevity, metabolic adaptation, and oxidative stress in overweight individuals. Journal of the American Medical Association, 295, 1539–1548.CrossRefGoogle ScholarPubMed
Herndon, L.A., Schmeissner, P.J., Dudaroneck, J.M., Brown, P.A., Listner, K.M., Sakano, Y., et al. . (2002). Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans. Nature, 419, 808–814.CrossRefGoogle ScholarPubMed
Hitt, R., Young-Xu, Y., Silver, M., et Perls, T. (1999). Centenarians: The older you get, the healthier you have been. Lancet, 354, 652.CrossRefGoogle ScholarPubMed
Ikeno, Y., Bronson, R.T., Hubbard, G.B., Lee, S. et Bartke, A. (2003). Delated occurrence of fatal neoplastic diseases in Ames dwarf mice: Correlation to extended longevity. Journal of Gerontology: Biological Sciences, 58A, 291–296.Google Scholar
Kinney, B.A., Coschigano, K.T., Kopchick, J.J., Steger, R.W. et Bartke, A. (2001). Evidence that age-related decline in memory retention is delayed in hormone resistant GH-R-KO (Laron) mice. Physiology et Behavior, 72, 653–660.CrossRefGoogle Scholar
Lane, M.R., Ingram, D.K., et Roth, G.S. (1999). Nutritional modulation of aging in nonhuman primates. Journal of Nutritional, Health et Aging, 3, 69–76.Google ScholarPubMed
Leslie, M. (2008). Searching for the secrets of the super old. Science, 321, 1764–1765.CrossRefGoogle ScholarPubMed
Miller, R.A. (2002). Extending life: Scientific prospects and political obstacles. Millbank Quarterly, 80, 155–174.CrossRefGoogle ScholarPubMed
Miller, R.A. (2009). “Dividends” from aging research—Can biogerontologists, at long last, find something useful to do? Journal of Gerontology: Biological Sciences, 64A, 157–160.Google Scholar
Olshansky, J., Carnes, B.A., et Cassel, C. (1990). In search of Methuselah: Estimating the upper limits to human longevity. Science, 250, 634–640.CrossRefGoogle ScholarPubMed
Olshansky, J., Perry, D., Miller, R.A., et Butler, R.N. (2006). In pursuit of the longevity dividend. Scientist, 20, 28–36.Google Scholar
Sierra, F. (2009). Biology of aging summit report. Journal of Gerontology: Biological Sciences, 64A, 155–156.Google Scholar
Sprott, R.L. (1999). Biomarkers of aging. Journal of Gerontology: Biological Sciences, 54A, B464–B465.Google Scholar
Vaupel, J.W., et Loichinger, E. (2006). Redistributing work in aging Europe. Science, 312, 1911–1913.CrossRefGoogle ScholarPubMed
Warner, H.R. (2004). Current status of efforts to measure and modulate the biological rate of aging. Journal of Gerontology: Biological Sciences, 59A, 692–696.Google Scholar
Warner, H.R. (2005). Longevity genes: From primitive organisms to humans. Mechanisms Ageing Development, 126, 235–242.CrossRefGoogle ScholarPubMed
Weindruch, R., et Walford, R.L. (1988). The retardation of aging and disease by dietary restriction. Springfield, IL: Charles C. Thomas.Google Scholar