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Plant gene targeting and gene replacement: application to crop genetic improvement

Published online by Cambridge University Press:  01 October 2008

Zhang Xiao-hui ,
Ye Zhi-biao ,
Zhang Yu-yang ,
Hou Zheng  and
Li Han-xia
Zhang Xiao-hui
Affiliation:
National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan 430070, China
Ye Zhi-biao
Affiliation:
National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan 430070, China National Center for Vegetable Improvement (Central China), Huazhong Agricultural University, Wuhan 430070, China
Zhang Yu-yang
Affiliation:
National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan 430070, China National Center for Vegetable Improvement (Central China), Huazhong Agricultural University, Wuhan 430070, China
Hou Zheng
Affiliation:
National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan 430070, China
Li Han-xia*
Affiliation:
National Center for Vegetable Improvement (Central China), Huazhong Agricultural University, Wuhan 430070, China
*
*Corresponding author. E-mail: hxli@mail.hzau.edu.cn
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Abstract

Recent advances and limitations of using zinc finger nuclease to stimulate a high efficiency of homologous recombination, and chimeric oligonucleotides to promote single base replacement in functional genomic research and plant genetic breeding, are systematically reviewed. Approaches to improve gene targeting efficiency through molecular modification of key pathways in plant homologous recombination are also discussed.

Keywords

targeted mutationgene replacementzinc finger nucleaseschimeric oligonucleotidesplant genetic improvement
Type
Review Article
Information
Chinese Journal of Agricultural Biotechnology , Volume 5 , Issue 2 , August 2008 , pp. 93 - 99
Copyright
Copyright © China Agricultural University 2008

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Footnotes

First published in Journal of Agricultural Biotechnology 2007, 15(6): 1058–1065

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