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Advances in the development of animal gene transfer

Published online by Cambridge University Press:  01 October 2008

Shi Zhen-Dan ,
Li Wan-Li ,
Zhang Yong-Liang  and
Chen Xue-Jin
Shi Zhen-Dan*
Affiliation:
Department of Animal Science, South China Agricultural University, Guangzhou 510642, China
Li Wan-Li
Affiliation:
Department of Animal Science, South China Agricultural University, Guangzhou 510642, China
Zhang Yong-Liang
Affiliation:
Department of Animal Science, South China Agricultural University, Guangzhou 510642, China
Chen Xue-Jin
Affiliation:
Centre for Laboratory Animals, Shanghai Jiaotong University, Shanghai 200092, China
*
*Corresponding author. E-mail: zdshi@scau.edu.cn
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Abstract

Efficiency and specificity are key limiting factors for the production of transgenic animals. This review describes the recently developed animal gene transfer techniques, including non-site-specific methods of gene transfer into the testis and ovary for easy production of transgenic animals; gene targeting in embryonic stem cells, somatic cells and primordial germ cells for site-specific methods; methods to improve cloning efficiency in gene targeting; and site- and timing-specific gene targeting and controlled expression of transferred genes. In addition, methods of utilizing newly developed RNA interference, combined with the above techniques for controlling gene expression, to produce transgenic animals to spatio-temporally and reversibly knock down specific genes, are also discussed. The merits and disadvantages of each method are covered, as well as the potential use of these methods to develop transgenic animals for breeding new animal lines, to study disease models and to produce therapeutic medicines.

Keywords

gene transfer methodsefficiencyspatio-temporal expressioncontrolled expressionRNA interference
Type
Review Article
Information
Chinese Journal of Agricultural Biotechnology , Volume 5 , Issue 2 , August 2008 , pp. 101 - 106
Copyright
Copyright © China Agricultural University 2008

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Footnotes

First published in Journal of Agricultural Biotechnology 2008, 16(1): 163–168

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