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Adsorption-desorption of sotalol hydrochloride by Na-montmorillonite

Published online by Cambridge University Press:  09 July 2018

M. Sánchez-Camazano ,
M. J. Sánchez-Martín ,
M. T. Vicente  and
A. Dominguez-Gil
M. Sánchez-Camazano
Affiliation:
Centro de Edafología y Biología Aplicada, Apdo. 257, 37008 Salamanca
M. J. Sánchez-Martín
Affiliation:
Centro de Edafología y Biología Aplicada, Apdo. 257, 37008 Salamanca
M. T. Vicente
Affiliation:
Departamento de Farmacia Galénica, Facultad de Farmacia Salamanca, Spain
A. Dominguez-Gil
Affiliation:
Departamento de Farmacia Galénica, Facultad de Farmacia Salamanca, Spain
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Abstract

The interaction of montmorillonite with sotalol hydrochloride (4-(1-hydroxy-N-isopropylaminoethyl) methane sulfanilide) was studied by means of adsorption isotherms, XRD and IR spectroscopy. The amount of sotalol adsorbed depended on pH, the maximum amount adsorbed (0·56 mEq g−1) being considerably less than the exchange capacity of the mineral (0·80 mEq g−1). XRD and IR data revealed that the sotalol is adsorbed into the interlayer space, forming a monolayer complex with a d001 spacing of 17·7 Å, and that the mechanisms involved are cation exchange and ion-dipole interactions. Experiments on the in vitro desorption of the drug from the sotalol-montmorillonite complex indicated that desorption is affected by pH, by the salt concentration of the electrolyte, and by the elimination rate of the desorbed organic cations.

Type
Research Article
Information
Clay Minerals , Volume 22 , Issue 2 , June 1987 , pp. 121 - 128
Copyright
Copyright © The Mineralogical Society of Great Britain and Ireland 1987

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