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Anticancer drugs loading into and in vitro release from faujasite

Published online by Cambridge University Press:  09 July 2018

M. Betsiou ,
G. Bantsis ,
I. Zoi  and
C. Sikalidis
M. Betsiou
Affiliation:
Department of Chemical Engineering, Aristotle University of Thessaloniki, Greece
G. Bantsis
Affiliation:
Department of Chemical Engineering, Aristotle University of Thessaloniki, Greece
I. Zoi
Affiliation:
Department of Chemistry, Aristotle University of Thessaloniki, Greece
C. Sikalidis*
Affiliation:
Department of Chemical Engineering, Aristotle University of Thessaloniki, Greece
*
*E-mail: sikalidi@auth.gr
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Abstract

This investigation was carried out to determine whether the adsorptive and ion-exchange properties of faujasite (FAU) could be used to delivery locally the anticancer drugs gemcitanine hydrochloride (dFdU.HCl) and oxaliplatin (DACH-Pt). A soaking procedure was used for the determination of the maximum adsorption capacity of FAU and the mechanism described here was achieved. 274 mg dFdU.HCl/g FAU were adsorbed in 16 h, while 48 h were needed for the adsorption of 79.7 mg DACH-Pt/g FAU. Drug release studies were carried out by soaking the samples of loaded FAU in simulation body fluids (SBF). After only one hour 76% of dFdU.HCl was released while the release of DACH-Pt from the FAU was more normal since 38% of DACH-Pt was released in the first 24 h.

Keywords

biomaterialdrug carrieranticancer drugsadsorption and release kineticsmolecular electrostatic potentialfaujasitezeolite
Type
Research Article
Information
Clay Minerals , Volume 46 , Issue 4 , December 2011 , pp. 613 - 619
Copyright
Copyright © The Mineralogical Society of Great Britain and Ireland 2011

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References

Ali, S.M., Khan, A.R., Ahmad, M.U., Chen, P., Sheikh, S. & Ahmad, I. (2005) Synthesis and biological evaluation of gemcitabine—lipid conjugate (NEO6002). Bioorganic & Medicinal Chemistry Letters, 15, 2571–2574.Google Scholar
Barroug, A. & Glimcher, M.J. (2002) Hydroxyapatite crystals as a local drug delivery system for cisplatin: adsorption and release of cisplatin in vitro. Applied Journal of Orthopaedic Research, 20, 274–280.Google Scholar
Becouarn, Y., Agostini, C., Trufflandier, N. & Boulanger, V. (2001) Oxaliplatin: available data in non-colo-rectal gastrointestinal malignancies. Critical Reviews in Oncology / Hematology, 40, 265–272.Google Scholar
Bonferoni, M.C., Cerri, G., Gennaro, M., Juliano, C. & Caramella, C. (2007) Zn2+-exchanged clinoptiloliterich rock as active carrier for antibiotics in anti-acne topical therapy. In-vitro characterization and preliminary formulation studies. Applied Clay Science, 36, 95–102.Google Scholar
Brannon-Peppas, L. (1997) Polymers in controlled drug delivery. Medical Plastics and Biomaterials Magazine, http://www.mddionline.com/article/polymers-controlled-drug-delivery Google Scholar
CAChe 7.5 (2006) Fujitsu, Beaverton, Oregon, USA.Google Scholar
Carrato, A., Gallego, J. & Diaz-Rubio, E. (2002) Oxaliplatin: results in colorectal carcinoma. Critical Reviews in Oncology / Hematology, 42, 29–44.Google Scholar
Colella, C. (2011) A critical reconsideration of biomedical and veterinary applications of natural zeolites. Clay Minerals, 46, 295–310.Google Scholar
Dahm, A. & Eriksson, H. (2004) Ultra-stable zeolites - a tool for in-cell chemistry. Journal of Biotechnology, 111, 279–290.Google Scholar
Dyer, A., Morgan, S., Welles, P. & Williams, C. (2000) The use of zeolites as slow release anthelmintic carriers. Journal of Helminthology, 74, 137–141.CrossRefGoogle ScholarPubMed
Elmore, A.R. (2003) Final report on the safety assessment of aluminum silicate, calcium silicate, magnesium aluminum silicate, magnesium silicate, magnesium trisilicate, sodium magnesium silicate, zirconium silicate, attapulgite, bentonite, Fuller's earth, hectorite, kaolin, lithium magnesium silicate, lithium magnesium sodium silicate, montmorillonite, pyrophyllite, and zeolite. International Journal of Toxicology, 22, 37–102.Google Scholar
Eloxatin. Prescribing information, http://products.sano-fi-aventis.us/eloxatin/eloxatin.html Google Scholar
Faghihian, H. & Pirouzi, M. (2009) Cis/trans-but-2-ene adsorption on natural and modified clinoptilolite. Clay Minerals, 44, 405–409.Google Scholar
Farías, T., Ruiz-Salvador, A.R. & Rivera, A. (2003) Interaction studies between drugs and a purified natural clinoptilolite. Microporous and Mesoporous Materials, 61, 117–125.Google Scholar
Freeman, K.B., Anliker, S., Hamilton, M., Osborne, D., Dhahir, P., Nelson, R. & Allerheiligen, S.R.B. (1995) Validated assays for the determination of gemcitabine in human plasma and urine using highperformance liquid chromatography with ultraviolet detection. Journal of Chromatography B: Biomedical Applications, 665, 171–181.Google Scholar
Frising, T. & Leflaive, P. (2008) Extraframework cation distributions in X and Y faujasite zeolites: A review. Microporous and Mesoporous Materials, 114, 27–63.Google Scholar
Gaussian 09 (2009) Gaussian Inc. Pittsburgh, Pennsylvania, USA.Google Scholar
Gemzar Indications & Dosage, http://www.rxlist.com/gemzardrug.htm#ids Google Scholar
Horcajada, P., Márquez-Alvarez, C., Ramila, A., Perez-Pariente, J. & Vallet-Regi, M. (2006) Controlled release of Ibuprofen from dealuminated faujasites. Solid State Sciences, 8, 1459–1465.CrossRefGoogle Scholar
Jobicm, H. & Bee, M. (1997) Diffusion in zeolites. Chemistry and structure, http://www.ill.eu/fileadmin/users_files/Annual_Report/AR-97/pdf/Chem.pdf Google Scholar
Kokubo, T. & Takadama, H. (2006) How useful is SBF in predicting in vivo bone bioactivity. Biomaterials, 27, 2907–2915.Google Scholar
Kralj, M. & Pavelic, K. (2003) Medicine on a small scale. European Molecular Biology Organization Reports, 4, 1008–1012.Google Scholar
Lobo, R.F. (2003) Introduction to the structural chemistry of zeolites. Pp. 63–87 in: Handbook of Zeolite Science and Technology (Ayerbach, S.M, Carrado, K.A. & Dutta, P.K., editors) Markel Dekker Inc., New York, U.S.A. Google Scholar
Mumpton, F.A. (1999) La roca magica: Uses of natural zeolites in agriculture and industry. Proceedings of the National Academy Sciences of the U.S.A., 96, 3463–3470.Google Scholar
PaveliPavelić, K. & Hadzija, M. (2003) Medical applications of zeolites. Pp.1128–1159 in: Handbook of Zeolite Science and Technology (Ayerbach, S.M, Carrado, K.A. & Dutta, P.K., editors) Markel Dekker Inc., New York, U.S.A. Google Scholar
Pavelić, K. Hadzija, M., Bedrica, L., Pavelić, J., Dikić, I., Katić, M., Kralj, M., Bosnar, M.H., Kapitanović, S., Poljak-Blazi, M., Krizanac, S., Stojković, R., Jurin, M., Subotić, B & Colic, M. (2001) Natural zeolite clinoptilolite: New adjuvant in anticancer therapy. Journal of Molecular Medicine, 78, 708–720.CrossRefGoogle ScholarPubMed
Pearce, H.L. & Miller, M.A. (2005) The evolution of cancer research and drug discovery at Lilly Research Laboratories. Advances in Enzyme Regulation, 45, 229–255.Google Scholar
Rimoli, M.G., Rabaioli, M.R., Melisi, D., Curcio, A., Mondello, S., Mirabelli, R. & Abignente, E. (2008) Synthetic zeolites as a new tool for drug delivery. Journal of Biomedical Materials Research, 87A, 156-164.Google Scholar
Rivera, A. & Fariás, T. (2005) Clinoptilolite—surfactant composites as drug support: A new potential application. Microporous and Mesoporous Materials, 80, 337–346.Google Scholar
Slejko, F.L. (1985) Pp. 13–14 in: Adsorption Technology. A Step-by—Step Approach to Process Evaluation and Application. Marcel Dekker.Google Scholar
Tyagi, P., Gahlot, P. & Kakka, R. (2008) Structural aspects of the anti-cancer drug oxaliplatin: A combined theoretical and experimental study. Polyhedron, 27, 3567–3574.Google Scholar
Yang, R.T. (2003) Pp. 157–190 in: Adsorbents: Fundamentals and Applications, John Wiley & Sons.Google Scholar