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Halloysite nanotubes as a new drug-delivery system: a review

Published online by Cambridge University Press:  02 January 2018

Muhammad Hanif ,
Fazila Jabbar ,
Sana Sharif ,
Ghulam Abbas ,
Athar Farooq  and
Mubashar Aziz
Muhammad Hanif*
Affiliation:
Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan
Fazila Jabbar
Affiliation:
Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan
Sana Sharif
Affiliation:
Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan
Ghulam Abbas
Affiliation:
Faculty of Pharmaceutical Sciences, Government College University, Faisalabad, Pakistan
Athar Farooq
Affiliation:
Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan
Mubashar Aziz
Affiliation:
Department of Pathobiology, Faculty of Veterinary Sciences, Bahauddin Zakariya University, Multan, Pakistan
*
*E-mail: muhammadhanif14@yahoo.com
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Abstract

New drug-delivery systems have remained a challenge for pharmaceutical scientists due to the use of expensive polymers and the low loading capacity of prepared nanoparticles. There is pressure to develop formulations that contain not only cheaper materials but also have controlled-release properties. Halloysite nanotubes (HNTs) are a naturally occurring clay mineral similar to kaolin, possessing a special particle shape in the form of an ultramicroscopic multilayered hollow cylinder. Its uses encompass a wide range in anticancer therapy, sustained- and controlled-release drug-delivery systems, cosmetics, delivery of proteins, vaccines and genes. These advantages are due to its biocompatibility, significant mechanical strength and natural availability. The surfaces of the tubules can be modified by coating different polymers for application in the drug-delivery system. This review is focused on the various aspects of HNTs such as structure, properties, loading methods, applications and characterizations.

Keywords

halloysite nanotubesdrug-delivery carriervacuum method
Type
Research Article
Information
Clay Minerals , Volume 51 , Issue 3 , June 2016 , pp. 469 - 477
Copyright
Copyright © The Mineralogical Society of Great Britain and Ireland 2016

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