Hostname: page-component-78c5997874-xbtfd Total loading time: 0 Render date: 2024-11-10T15:31:42.105Z Has data issue: false hasContentIssue false
  • English
  • Français

Preparation of drug-montmorillonite UV-radiation protection compounds by gas-solid adsorption

Published online by Cambridge University Press:  09 July 2018

C. del Hoyo ,
M. A. Vicente  and
V. Rives
C. del Hoyo
Affiliation:
Departamento de Química Inorgánica, Universidad de Salamanca, 37008-Salamanca, Spain Unidad Asociada IRNASA(CSIC)-Universidad de Salamanca, c/ Cordel de Merinas, s/n, 37008-Salamanca, Spain
M. A. Vicente*
Affiliation:
Unidad Asociada IRNASA(CSIC)-Universidad de Salamanca, c/ Cordel de Merinas, s/n, 37008-Salamanca, Spain Instituto de Recursos Naturales y Agrobiología, Consejo Superior de Investigaciones Científicas, c/Cordel deMerinas, s/n, 37008- Salamanca, Spain
V. Rives*
Affiliation:
Departamento de Química Inorgánica, Universidad de Salamanca, 37008-Salamanca, Spain Unidad Asociada IRNASA(CSIC)-Universidad de Salamanca, c/ Cordel de Merinas, s/n, 37008-Salamanca, Spain
*
†Deceased
*E-mail: vrives@gugu.usal.es
Get access Rights & Permissions [Opens in a new window]

Abstract

Ethyl cinnamate/montmorillonite intercalation complexes were obtained by gaseous adsorption of the drug on the clay surface. They were characterized by powder X-ray diffraction, differential thermal and thermogravimetric analyses and by visible-UV and IR spectroscopies. It was found that after 1 day of adsorption, most of the drug enters the interlayer space of the clay by substitution of water molecules, and is removed only after heating at high temperature. In addition, a portion is physisorbed on the external surface of the crystallites, being removed easily below 100°C. The interlayer complex improves the protecting ability of the pure clay or the pure drug against ultraviolet radiation, specially in the so-called ‘C’ range (290–190 nm).

Keywords

montmorilloniteethyl cinnamatedrug-clay interactiongas-solid adsorptionUV radiation protection
Type
Research Article
Information
Clay Minerals , Volume 36 , Issue 4 , December 2001 , pp. 541 - 546
Copyright
Copyright © The Mineralogical Society of Great Britain and Ireland 2001

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Cairns-Smith, A.G. & Hartman, H. (1986) Clay Minerals and the Origin of Life. Cambridge University Press, Cambridge.Google Scholar
Čičel, B. & Kranz, G. (1981) Mechanism of montmorillonite structure degradation by percussive grinding. Clay Miner. 16, 151–162.CrossRefGoogle Scholar
Del Hoyo, C. (1995) Pharmaceutical/ clay systems: preparation, characterization and application as ultraviolet radiation shelters. PhD thesis, Univ. Salamanca, Spain.Google Scholar
Del Hoyo, C., Rives, V. & Vicente, M.A. (1996a) Adsorption of melted drugs on smectite. Clays Clay Miner. 44, 424–428.CrossRefGoogle Scholar
Del Hoyo, C., Rives, V. & Vicente, M.A. (1996b) Application of methyl cinnamate/montmorillonite as ultraviolet radiation shelters. Drug Dev. Ind. Pharm. 22, 1089–1095.Google Scholar
Del Hoyo, C., Rives, V. & Vicente, M.A. (1998) Application of phenyl salicylate-sepiolite systems as ultraviolet radiation filters. Clay Miner. 33, 467–474.CrossRefGoogle Scholar
Farmer, V.C. (1974) The Infrared Spectra of Minerals. Monograph, 4. Mineralogical Society, London.Google Scholar
Forteza, M., Galán, E. & Cornejo, J. (1989) Interaction of dexamethasone and montmorillonite. Adsorptiondegradation process. Appl. Clay Sci. 4, 437–448.Google Scholar
Hermosín, C., Cornejo, J., White, J.L. & Hem, S.L. (1981) Sepiolite: a potential excipient for drugs subject to oxidative degradation. J. Pharm. Sci. 70, 189–192.CrossRefGoogle ScholarPubMed
MacKenzie, R.C. (1970) Differencial Thermal Analysis (Vol. 1). Academic Press, London.Google Scholar
Mortland, M.M. (1970) Clay-organic complexes and interactions. Adv. Agron. 22, 75–117.Google Scholar
Porubcan, J.S., Serna, C.J., White, J.L. & Hem, S.L. (1978) Mechanism of adsorption of clinamycin and tetracycline by montmorillonite. J. Pharm. Sci. 67, 1081–1087.CrossRefGoogle ScholarPubMed
Rausell-Colom, J.A. & Serratosa, J.M. (1987) Reactions of clays with organic substances. Pp. 371–442 in. Chemistry of Clays and Clay Minerals. Monograph, 6. Mineralogical Society, London.Google Scholar
Sánchez-Martín, M.J., Sánchez-Camazano, M., Vicente- Hernández, M.T. & Domínguez-Gil, A. (1981) Interaction of propranolol hydrochloride with montmorillonite. J. Pharm. Pharmacol. 33, 408–410.CrossRefGoogle ScholarPubMed
Sayalero, M.L. (1982) Study of the interaction between cardiac drugs and montmorillonite. PhD thesis, Univ. Salamanca, Spain.Google Scholar
The Merck Index (1989) 11th Ed. Centennial Edition. Merck and Co., Inc., Rahway, N.J., USA.Google Scholar
Theng, B.K.G. (1974) The Chemistry of Clay-Organic Reactions. Wiley, New York.Google Scholar
Vicente, M.T. (1981) Study of the interaction between adrenergic blockeants and montmorillonite. PhD thesis, Univ. Salamanca, Spain.Google Scholar
Vicente, M.A., Sánchez-Camazano, M., Sánchez-Martín, M.J., Del Arco, M., Martín, C., Rives, V. & Vicente- Hernández, J. (1989). Adsorption and desorption of N-methyl-8-hydroxy quinoline methyl sulfate on smectite and the potential use of the clay-organic product as an ultraviolet radiation collector. Clays Clay Miner. 37, 157–163.Google Scholar
White, J.L. & Hem, S.L. (1983). Pharmaceutical aspects of clay-drug interactions. Ind. Eng. Chem. Prod. Res. Dev. 22, 665–671.Google Scholar