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A simple and efficient method for manufacturing porous bioceramics

Published online by Cambridge University Press:  09 July 2018

Chuisheng Zeng ,
Xiaoming Chen ,
Yuhua Yan ,
Yanjun Zeng ,
Xiaoying Tang  and
Yilong Liang
Chuisheng Zeng
Affiliation:
College of Bio-Infomation, Chongqing University of Post & Telecommunication, Chongqing 400065, China
Xiaoming Chen
Affiliation:
Biomedical Materials and Engineering Center, Wuhan University of Technology, Wuhan 430070, China
Yuhua Yan
Affiliation:
Biomedical Materials and Engineering Center, Wuhan University of Technology, Wuhan 430070, China
Yanjun Zeng*
Affiliation:
Biomechanics & Medical Information Institute, Beijing University of Technology, Beijing 100022, China
Xiaoying Tang
Affiliation:
School of Life Science and Technology, Beijing Institute of Technology, Beijing 100081, China
Yilong Liang
Affiliation:
College of Bio-Infomation, Chongqing University of Post & Telecommunication, Chongqing 400065, China
*
*E-mail: yjzeng@bjut.edu.cn
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Abstract

The purpose of this study was to develop a simple and efficient method for manufacturing porous bioceramics, in which small organic foam spheres were taken as the poremaking reagent and green bodies were made by hot die-casting in moulds. The raw materials (small organic foam spheres, paraffin, oleic acid and β-TCP powder) were mixed into a slurry at 30–120ºC and moulded into green bodies using a hot die-casting machine at 30–90ºC; the green bodies were then sintered and the porous bioceramics obtained. The main characteristics (structure and size of pores, water permeability, apparent porosity and shrinkage) were tested. The results indicated that the apparent porosity was high and directly proportional to the mass ratio between the small organic foam spheres and the β-TCP powder. The pores connected with each other in three dimensions; the size, distribution of the shapes and structures of the pores were clearly related to the dimensions of the small organic foam spheres. The water permeability was proportional to the hot die-casting pressures and the shapes of the samples could easily be controlled by selecting different moulds. This study indicated that the method can be used to manufacture porous bioceramics with controlled pore structures and different shapes effectively and easily by adding different amounts and sizes of small organic foam spheres, mixing the raw materials evenly, and by selection of the hot die-casting pressure and by the use of different moulds.

Keywords

pore structurehot die-castingporous bioceramicscontrolled pore sizecontrolled pore structuresmall organic foam spheres
Type
Research Papers
Information
Clay Minerals , Volume 46 , Issue 1 , March 2011 , pp. 157 - 163
Copyright
Copyright © The Mineralogical Society of Great Britain and Ireland 2011

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References

Araki, K. & Halloran, J.W. (2005) Porous ceramic bodies with interconnected pore channels by a novel freeze casting technique. Journal of the American Ceramic Society, 88, 1108–1114.Google Scholar
Barralet, J.E., Grover, L., Gaunt, T., Wright, A.J. & Gibson, I.R. (2002) Preparation of macroporous calcium phosphate cement tissue engineering scaffold. Biomaterials, 23, 3063–3072.CrossRefGoogle ScholarPubMed
Callcut, S. & Knowles, J.C. (2002) Correlation between structure and compressive strength in a reticulated glass-reinforced hydroxyapaptite foam. Journal of Materials Science: Materials in Medicine, 13, 485–489.Google Scholar
Chuisheng, Zeng, Xiaoming, Chen, Yuhua, Yan, Xiaoying, Tang, Yilong, Liang, Zhiqiang, Zhao & Yanjun, Zeng (2010) Apparent porosity of porous bioceramics prepared with small organic foam spheres as the pore-making reagent. Clay Minerals, 45, 449–452.Google Scholar
De Groot, K. (1980) Bioceramics consisting of calcium phosphate salts. Biomaterials, 1, 47–50.Google Scholar
Ducheyne, P. & Qiu, Q. (1999) Bioactive ceramics: the effect of surface reactivity on bone formation and bone cell fuction. Biomaterials, 20, 2287–2303.CrossRefGoogle Scholar
Freyman, T.M., Yannas, I.V. & Gibson, L.J. (2001) Cellular materials as porous scaffolds for tissue engineering. Progress in Materilas Science, 46, 273–82.CrossRefGoogle Scholar
Hench, L.L. & Polak, J.M. (2002) Third-generation biomedical materials. Science, 295, 1014–1017.CrossRefGoogle ScholarPubMed
Ishaug, S.L., Crane, G.M., Miller, M.J., Yasko, A.W., Yaszemski, M.J. & Mikos, A.G. (1997) Bone formation by three-dimensional stromal osteoblast culture in biodegradable polymer scaffolds. Journal of Biomedical Materials Research, 36, 17–28.Google Scholar
John, A., Varma, H.K. & Kumari, T.V. (2003) Surface reactivity of calcium phosphate based ceramics in a cell culture system. Journal of Biomaterials Applications, 18, 63–78.CrossRefGoogle Scholar
Jun, I.K., Koh, Y.H., Song, J.H., Lee, S.H. & Kim, H.E. (2006) Improved compressive strength of reticulated porous zirconia using carbon coated polymeric sponge as novel template. Materials Letters, 60, 2507–2510.Google Scholar
Lee, E.J., Koh, Y.H., Yoon, B.H., Kim, H.E. & Kim, H.W. (2007) Highly porous hydroxyapatite bioceramics with interconnected pore channels using camphenebased freeze casting. Materials Letters, 61, 2270–2273.CrossRefGoogle Scholar
Lee, Y.M., Seol, Y.J., Lim, Y.T., Kim, S., Han, S.B., Rhyu, I.C., Baek, S.H., Heo, S.J., Choi, J.Y., Klokkevold, P.R. & Chung, C.P. (2001) Tissue engineered growth of bone by marrow cell transplantation using porous calcium metaphosphate matrices. Journal of Biomedical Materials Research, 54, 216–223.3.0.CO;2-C>CrossRefGoogle ScholarPubMed
LeGeros, R.Z. (1993) Biodegradation and bioresorption of calcium phosphate ceramics. Clinical Materials, 14, 65–88.Google Scholar
Li, S.H., De Wijn, J.R., Layrolle, P., de Groot, K. & Biomed, J. (2002) Synthesis of macroporous hydroxyapatite scaffolds for bone tissue engineering. Journal of Biomedical Materials Research, 61, 109–120.Google Scholar
Livingston, T., Ducheyne, P. & Garino, J. (2002) In vivo evaluation of a bioactive scaffold for bone tissue engineering. Journal of Biomedical Materials Research, 62, 1–13.Google Scholar
Lu, J.X., Flautre, B. & Anselme, K. (1997) Study of porous interconnection of bioceramic on cellular rehabilitation in vitro and in vivo. Biomaterials, 10, 583–586.Google Scholar
Ohgushi, H. & Yoshikawa T (1992) Bone formation process in porous calcium carbonate and hydroxyapatite. Biomedical Material Research A, 26, 885–895.CrossRefGoogle ScholarPubMed
Radin, S.R. & Ducheyne, P. (1993) The effect of calcium phosphate ceramic composition and structure on in vitro behavior. Journal of Biomedical Materials Research, 27, 35–45.CrossRefGoogle ScholarPubMed
Sepulveda, P. & Binner, J.G.P. (1999) Processing of cellular ceramics by foaming and in situ polymerization of organic monomers. Journal of the European Ceramic Society, 19, 2059–2066 CrossRefGoogle Scholar
Suquet, H., Chevalier, S., Marcilly, C. & Barthomeuf, D. (1991) Preparation of porous materials by chemical activation of the Llano vermiculite. Clay Minerals, 26, 49–60.CrossRefGoogle Scholar
Takahashi, T., Yamamoto, M., Ioku, K.. & Goto, S. (1997) Relationship between compressive strength and pore structure of hardened cement pastes. Advances in Cement Research, 9, 25–30.Google Scholar
Tampieri, A., Celotti, G. & Landi, E. (2005) From biomimetic apatites to biologically inspired composites. Analytical and Bioanalytical Chemistry, 381, 568–76.CrossRefGoogle ScholarPubMed
Wang, Z., Chang, J., Bai, F., Sun, X.J., Lin, K.L. & Chen, L. (2010) Role of the porous structure of the bioceramic scaffolds in bone tissue engineering. Nature Precedings: hdl:10101/npre..4148.1 Google Scholar