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Solubility and release of fenamates intercalated in layered double hydroxides

Published online by Cambridge University Press:  09 July 2018

M. Del Arco ,
A. Fernández ,
C. Martín ,
M. L. Sayalero  and
V. Rives
M. Del Arco
Affiliation:
GIR-QUESCAT, Departamento de Química Inorgánica, Universidad de Salamanca, Salamanca, Spain
A. Fernández
Affiliation:
GIR-QUESCAT, Departamento de Química Inorgánica, Universidad de Salamanca, Salamanca, Spain
C. Martín
Affiliation:
GIR-QUESCAT, Departamento de Química Inorgánica, Universidad de Salamanca, Salamanca, Spain
M. L. Sayalero
Affiliation:
Departamento de Farmacia y Tecnología Farmacéutica, Universidad de Salamanca, Salamanca, Spain
V. Rives*
Affiliation:
GIR-QUESCAT, Departamento de Química Inorgánica, Universidad de Salamanca, Salamanca, Spain
*
*E-mail: vrives@usal.es
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Abstract

The effect of a Mg- and Al-containing layered double hydroxide (LDH), used as an additive or as a matrix, on the dissolution and solubility of two non-steroidal anti-inflammatory drugs (NSAIDs), namely, mefenamic and meclofenamic acids, is reported. The use of MgAl-LDH enhances the solubility of mefenamic acid at the three pH values tested, and the value is larger when the acid is intercalated as opposed to simply being mixed with the layered material. For pure mefenamic acid, the most unfavourable pH is 1.2, while for the physical mixture and the sample with the intercalated drug, the most unfavourable pH is 4.5, for which the minimum increase in the amount of dissolved acid is recorded. The (dissolution) release-rate for both drugs when they are intercalated between the layers is much slower than for the physical mixture or for the dissolution of the pure drug.

Keywords

hydrotalciteanti-inflammatoryfenamate acidscontrolled releasesolubilityNSAID
Type
Research Article
Information
Clay Minerals , Volume 43 , Issue 2 , June 2008 , pp. 255 - 265
Copyright
Copyright © The Mineralogical Society of Great Britain and Ireland 2008

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