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Lack of Association of Apolipoprotein E Polymorphism in Obsessive-Compulsive Disorder

Published online by Cambridge University Press:  07 November 2014

Humberto Nicolini ,
Nora Urraca ,
Beatriz Camarena ,
Amalia Gómez ,
Hortensia Martínez ,
Gina Rinetti ,
Carlos Campillo ,
Paola Castelli ,
Rogelio Apiquián  and
Ana Fresán
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Abstract

Obsessive-compulsive disorder (OCD) could be considered a neurodevelopmental disorder, from several lines of evidence. One of the most widely studied genes in these disorders is the apolipoprotein E gene, particularly allele 4. We analyzed for association among patients with OCD versus normal controls and cognitively impaired patients. There were no significant differences between OCD probands compared with population controls. However, the cognitively impaired group showed a higher frequency of allele apolipoprotein E gene compared with normal controls and patients with OCD.

Type
Original Research
Information
CNS Spectrums , Volume 6 , Issue 12: The White Paper Issue 2001 , December 2001 , pp. 978 - 979, 992
Copyright
Copyright © Cambridge University Press 2001

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