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The Neuroanatomy of Serotonin (5-HT) Dysregulation in Obsessive-Compulsive Disorder

Published online by Cambridge University Press:  07 November 2014

Gregory Grove ,
Jeremy Coplan ,
Lisa Margolin  and
Eric Hollander
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Abstract

A growing body of evidence suggests that obsessive-compulsive disorder (OCD) may be associated with alterations of the serotonin (5-HT) system and that the dorsal raphe nucleus (DRN) may play a role in OCD. In this report, we review this evidence and explore the possible roles of 5-HT and DRN as they relate to OCD.

Type
Feature Articles
Information
CNS Spectrums , Volume 1 , Issue 2 , November 1996 , pp. 16 - 22
Copyright
Copyright © Cambridge University Press 1996

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References

1.Modell, J, Mountez, JM, Curtis, GC, Greden, JF. Neurophysiologic dysfunction in basal ganglia/limbic striatal and thalamocortical circuits as a pathogenic mechanism of obsessive compulsive disorder. J Neuropsychiatry. 1989;1:27–36.Google Scholar
2.Murphy, DL, Zohar, J, Benkelfat, C, Pato, MT, Pigott, TA, Insel, TR. Obsessive-compulsive disorder as a 5-HT subsystem-related behavioural disorder. Br J Psychiatry. 1989; 155:15–24.CrossRefGoogle Scholar
3.Hollander, E, De Caria, C, Liebowitz, MR. Biological aspects of obsessive-compulsive disorder. Psychiatric Annals. 1989:19:80–87.CrossRefGoogle Scholar
4.Gorman, JM, Fyer, MR, Goetz, K, et al. , An open trial of fluoxetine in the treatment of panic attacks. J Clin Psychopharmacol. 1987:7:329–332.CrossRefGoogle ScholarPubMed
5.Gorman, JM, Fyer, MR, Liebowitz, MR, Klein, DF. Pharmacological provocation of panic attacks. In: Meltzer, Herbert, ed. Psychopharmacology: The Third Generation of Progress. New York, NY: Raven Press; 1987:985–993.Google Scholar
6.Schneier, FR, Liebowitz, MR, Davies, SO, et al. , Fluoxetine in panic disorder. J Clin Psychopharmacol. 1990;10:119–121.CrossRefGoogle ScholarPubMed
7.Hollander, E, Decaria, C, Liebowitz, MR. Biological aspects of obsessive-compulsive disorder. Psychiatric Annals. 1989;19(2):80–87.CrossRefGoogle Scholar
8.Hollander, E, Wong, C. Developments in the treatment of obsessive-compulsive disorder. Primary Psychiatry. 1995; 2:28–33.Google Scholar
9.Baxter, LR Jr, Schwartz, JM, Mazziotta, JC, et al. , Caudate glucose metabolic rate changes with both drug and behavior therapy for obsessive-compulsive disorder. Arch Gen Psychiatry. 1992;49:681–689.CrossRefGoogle ScholarPubMed
10.Hollander, E, DeCaria, C, Nitescu, A, et al. , Serotonergic function in obsessive-compulsive disorder: behavioral and neuroendocrine responses to oral m-chlorophenylpiperazine and fenfluramine in patients and healthy volunteers. Arch Gen Psychiatry. 1992;49:21–28.CrossRefGoogle ScholarPubMed
11.Schwartz, JM, Stoessel, PW, Baxter, LR Jr, Martin, KM, Phelps, ME. Systematic changes in cerebral glucose metabolic rate after successful behavior modification treatment of obsessive compulsive disorder. Arch Gen Psychiatry. 1996:53:109–113.CrossRefGoogle ScholarPubMed
12.Mindus, P, Rauch, SL, Nyman, H, et al. , Capsulotomy and cingulotomy as treatment for malignant OCD: an update. In: Current Insights in OGD. Hollander, E, Zohar, J, Marazziti, D, eds. West Sussex, England: John Wiley & Sons, Ltd; 1994:245–276.Google Scholar
13.Calabrese, G, Colombo, C, Bonfanti, A, Scotti, G. Caudate nucleus abnormalities in obsessive-compulsive disorder: measurements of MRI signal intensity. Psychiatry Resident. 1993;50:89–92.CrossRefGoogle ScholarPubMed
14.Baxter, LR Jr, Schwartz, JM, Bergman, KS, et al. , Cerebral glucose metabolic rates in non-depressed patients with obsessive-compulsive disorder. Am J Psychiatry. 1988;145:1560–1563.Google Scholar
15.Rubin, RT, Villanueva-Meyer, J, Ananth, J, Trajmar, PG, Mena, I. Regional xenon 133 cerebral blood flow and cerebral technetium 99m HMPAO uptake in unmedicated patients with obsessive-compulsive disorder and matched normal control subjects. Arch Gen Psychiatry. 1992;49:695–702.CrossRefGoogle ScholarPubMed
16.Swedo, SE, Pietrini, P, Leonard, H, et al. , Cerebral glucose metabolism in childhood-onset obsessive-compulsive disorder: revisualization during pharmacotherapy. Arch Gen Psychiatry. 1992;49:690–694.CrossRefGoogle ScholarPubMed
17.Flor, HP. Le syndrome obsessionnel-compulsif: reflet d'un defaut de regulation fronto-caudee de l'hemisphere gauche? Encephale. 1990;16:325–329.Google Scholar
18.Laplane, D, Levasseur, M, Pillon, B, et al. , Obsessive-compulsive and other behavioural changes with bilateral basal ganglia lesions. Brain. 1989:112(pt 3):699–725.CrossRefGoogle ScholarPubMed
19.Penisson-Besinier, I, Le Gall, D, Dubas, F. Comportement compulsif d'allure obsessionnelle (arithmomanie)—Atrophie des noyauxcaudes. RevNeurol. 1992;148:262–267.Google Scholar
20.Martin, J. Neuroanatomy Text and Atlas. New York, NY: Elsevier Science Publishing Co, Inc; 1989.Google Scholar
21.Azmitia, EC. The CNS serotonergic system: progression toward a collaborative organization. In: Meltzer, Herbert, ed. Psychopharmacology: The Third Generation of Progress. New York, NY: Raven Press; 1987:61–73.Google Scholar
22.Meltzer, HY, ed. Current Practices and Future Developments in the Psychopharmacology of Mental Disorders. New York, NY: Elsevier Science Publishing Co, Inc; 1991:83–88.Google Scholar
23.Toerk, I, Hornung, JP. Raphe nuclei and the serotonergic system. In: The Human Nervous System. Academic Press, Inc; 1990.Google Scholar
24.Grove, G, Coplan, J, Hollander, E. Neuroanatomy of 5(5-HT) dysregulation and panic disorder. J Neuropsychiatry Clin Neurosci. In press.Google Scholar
25.Kandel, ER, Schwartz, JH. Jessell, TM. Principles of Neural Science. 3rd ed. New York, NY: Elsevier Science Publishing Co, Inc; 1991.Google Scholar
26.Insel, T. Toward a neuroanatomy of obsessive-compulsive disorder. Arch Gen Psychiatry. 1992;49:739–744.CrossRefGoogle Scholar
27.Flament, MF, Rapoport, JL, Berg, CJ, et al. , Clomipramine treatment of childhood obsessive compulsive disorder: a double-blind controlled study. Arch Gen Psychiatry. 1985;42:977–986.CrossRefGoogle ScholarPubMed
28.Hollander, E, Prohovnik, I, Stein, DJ. Effects of m-CPP induced obsessions on cortical blood flow. J Neuro-psychiatry Clin Neurosci. Fall 1995;7(4):485–490Google Scholar
29.Insel, T, Pickar, D. Naloxone administration in obsessive-compulsive disorder: report of two cases. Am J Psychiatry. 1983;140:1219–1220Google Scholar