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Selecting a Serotonin Reuptake Inhibitor for Obsessive-Compulsive Disorder

Published online by Cambridge University Press:  07 November 2014

Alison Kelly
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Abstract

Although considered rare and intractable until relatively recently, obsessive-compulsive disorder (OCD) is now recognized as a common condition that can be treated. Clomipramine initially dominated the treatment of OCD, but the introduction of the selective serotonin reup-take inhibitors (SSRIs) now allows OCD to be treated without the unpleasant adverse effects associated with the high doses of clomipramine necessary in OCD. Double-blind, placebo-controlled, and active treatment comparison trials showing the efficacy of fluvoxamine and fluoxetine in particular now provide good reasons to consider SSRIs as first-line therapy for OCD.

Type
Feature Articles
Information
CNS Spectrums , Volume 1 , Issue 2 , November 1996 , pp. 32 - 38
Copyright
Copyright © Cambridge University Press 1996

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References

1.Black, A. The natural history of obsessional neurosis. In: Beech, HR, ed. Obsessional States. London: Methuen & Co; 1974.Google Scholar
2.Karno, M, Golding, J, Sorenson, S, Burnham, MA. The epidemiology of obsessive-compulsive disorder in five US communities. Arch Gen Psychiatry. 1988;45:1094–1099.CrossRefGoogle ScholarPubMed
3.Hollander, E, Fay, M, Cohen, B, et al. , Serotonergic and noradrenergic sensitivity in obsessive-compulsive disorder: behavioural findings. Am J Psychiatry. 1988;145:1015–1017.Google Scholar
4.Zohar, J, Meuller, EA, Insel, TR, et al. , Serotonergic responsivity in obsessive-compulsive disorder: comparison of patients and healthy controls. Arch Gen Psychiatry. 1987;44:946–951.CrossRefGoogle ScholarPubMed
5.Bastani, B, Nash, JF, Meltzer, HY. Prolactin and cortisol responses to MK212, a serotonin agonist in obsessive compulsive disorder. Arch Gen Psychiatry. 1990;47:833–837.CrossRefGoogle ScholarPubMed
6.Insel, TR, Mueller, EA, Alterman, I. Pathogenesis of obsessive compulsive disorder and serotonin: is there a connection? Biol Psychiatry. 1985;20:1174–1188.CrossRefGoogle Scholar
7.Thoren, P, Asberg, M, Cronholm, B, Jornestedt, L, Traskman, L. Clomipramine treatment of obsessive-compulsive disorder: a controlled clinical trial. Arch Gen Psychiatry. 1980;37: 1281–1285.CrossRefGoogle ScholarPubMed
8.Ananth, J, Pecknold, JC, van den Steen, N, Engelsmann F. Double-blind comparative study of clomipramine and amitriptyline in obsessive neurosis. Prog Neuropsychopharmacol. 1981;5:257–262.CrossRefGoogle ScholarPubMed
9.Volavka, J, Neziroglu, F. Yarayura-Tobias, JA. Clomipramine and imipramine in obsessive compulsive disorder. Psychiat Res. 1985;14:83–91.CrossRefGoogle ScholarPubMed
10.Leonard, HL, Swedo, SE, Rapoport, JL, et al. , Treatment of obsessive compulsive disorder with clomipramine and desipramine in children and adolescents. Arch Gen Psychiatry. 1989;46:1088–1092.CrossRefGoogle ScholarPubMed
11.Ananth, J, Pecknold, JC, Van Der Steen, N, et al. , Double-blind comparative study of clomipramine and amitriptyline in obsessive neurosis. Prog Neuropsychopharmacoi. 1981;5: 257–262.CrossRefGoogle ScholarPubMed
12.DeVeaugh-Geiss, J, Landau, P, Katz, R. Preliminary results from a multicenter trial of clomipramine in obsessive-compulsive disorder. Psychopharmacol Bull. 1989;25:36–40.Google ScholarPubMed
13.Jenike, MA, Baer, L, Summergrad, P, Weilburg, JB, Holland, A, Seymour, R. Obsessive-compulsive disorder: a double-blind, placebo-controlled trial of clomipramine in 27 patients. Am J Psychiatry. 1989;146:1328–1330.Google ScholarPubMed
14.Katz, RJ, Landau, P, DeVeaugh-Geiss, J, Hakkarainen, H. Therapeutic effects of anafranil in obsessive compulsive disorder. Recent clinical findings. Prog Clin Biol Res. 1990:361:489–493.Google ScholarPubMed
15.Greist, JH, Jefferson, JW, Rosenfeld, R. Gutzmann, LD, March, JS, Barklage, NE. Clomipramine and obsessive compulsive disorder: a placebo-controlled double-blind study of 32 patients. J CM Psychiatry. 1990;51:292–297.Google ScholarPubMed
16.The Clomipramine Collaborative Study Group. Clomipramine in the treatment of patients with obsessive-compulsive disorder. Arch Gen Psychiatry. 1991;48:730–738.CrossRefGoogle Scholar
17.Pato, MT, Pigott, TA, Hill, JL, Grover, GN, Bernstein, S, Murphy, DL. Controlled comparison of buspirone and clomipramine in obsessive-compulsive disorder. Am J Psychiatry. 1991; 148:127–129.Google ScholarPubMed
18.Hewlett, WA, Vinogradov, S, Agras, WS. Clomipramine, clonazepam, and clonidine treatment of obsessive-compulsive disorder. J CM Psychopharmacol. 1992:12:420–430.Google ScholarPubMed
19.Vallejo, J, Olivares, J, Marcos, T, Bulbena, A, Menchon, JM. Clomipramine versus phenelzine in obsessive-compulsive disorder. A controlled clinical trial. Br J Psychiatry. 1992;161:665–670.CrossRefGoogle ScholarPubMed
20.Perse, TL, Greist, JH, Jefferson, JW, Rosenfeld, R, Dar, R. Fluvoxamine treatment of obsessive-compulsive disorder. Am J Psychiatry. 1987;144:1543–1548.Google ScholarPubMed
21.Goodman, WK, Price, LH, Rasmussen, SA, Delgado, PL, Heninger, GR, Charney, DS. Efficacy of fluvoxamine in obsessive-compulsive disorder. A double-blind comparison with placebo. Arch Gen Psychiatry. 1989;46:36–44.CrossRefGoogle ScholarPubMed
22.Jenike, MA, Hyman, S, Baer, L, et al. , A controlled trial of fluvoxamine in obsessive-compulsive disorder: implications for a serotonergic theory. Am J Psychiatry. 1990;48:1415–1416.Google Scholar
23.Mallaya, GK, White, K, Waternaux, G, Quay, S. Short- and long-term treatment of obsessive compulsive disorder. Ann CM Psychiatry. 1992;4:77–80.CrossRefGoogle Scholar
24.Greist, JH, Jenike, MA, Robinson, D, Rasmussen, SA. Efficacy of fluvoxamine in obsessive-compulsive disorder: results of a multicentre, double-blind, placebo-controlled trial. Eur J Clin Res. 1995;7:195–204.Google Scholar
25.Goodman, WK, Kozak, MJ, Liebowitz, M, White, KL. Treatment of obsessive-compulsive disorder with fluvoxamine: a multicentre, double-blind, placebo-controlled trial. Int Clin Psychopharmacol In press.Google Scholar
26.Smeraldi, E, Erzegovesi, S, Bianchi, I, Pasquali, L, Cocchi, S, Ronchi, P. Fluvoxamine vs clomipramine treatment in obsessive compulsive disorder: a preliminary study. New Trends Exp Clin Psychiatry. 1992;8:63–65.Google Scholar
27.Freeman, CP, Trimble, MR, Deakin, JF, Stokes, TM, Ashford, JJ. Fluvoxamine versus clomipramine in the treatment of obsessive compulsive disorder: a multicenter, randomized, double-blind, parallel-group comparison. J Clin Psychiatry. 1994;55:301–305.Google ScholarPubMed
28.Yargic, LI, Enderer, M, Imre, H, Sen, D, Yazici, O. A randomized, single-blind comparison of clomipramine and fluvoxamine in OCD patients. Nowpsikiyatr Ars. 1995;32:70–75.Google Scholar
29.Koran, LM, McElroy, SL, Davidson, JRT, Rasmussen, SA, Hollander, E, Jenike, MA. Fluvoxamine versus clomipramine for obsessive-compulsive disorder: a double-blind comparison. J Clin Psychopharmacol. In press.Google Scholar
30.Goodman, WK, Price, LH, Delgado, PL, et al. , Specificity of serotonin reuptake inhibitors in the treatment of obsessive-compulsive disorder. Comparison of fluvoxamine and desipramine. Arch Gen Psychiatry. 1990;48:483–484.Google Scholar
31.Pigott, TA, Pato, MT, Bernstein, SE, et al. , Controlled comparisons of clomipramine and fluoxetine in the treatment of obsessive-compulsive disorder. Behavioural and biological results. Arch Gen Psychiatry. 1990;47:926–932.CrossRefGoogle ScholarPubMed
32.Ananth, J, Elmishad, A, Wohl, M. Clomipramine vs fluoxetine in obsessive compulsive disorder: an uncontrolled study. Adv Ther. 1993;10:288–292.Google Scholar
33.Montgomery, SA, Mclntyre, A, Osterheider, M, et al. , for The Lilly European OCD Study Group. A double-blind, placebo-controlled study of fluoxetine in patients with DSM-IIl-R obsessive-compulsive disorder. Eur Neuropsychopharmacol. 1993;3:143–152.CrossRefGoogle ScholarPubMed
34.Tollefson, GD, Rampey, AH, Potvin, JH, et al. , A multicenter investigation of fixed-dose fluoxetine in the treatment of obsessive compulsive disorder. Arch Gen Psychiatry. 1994;51:559–567.CrossRefGoogle ScholarPubMed
35.Chouinard, G, Goodman, W, Greist, J, et al. , Results of a double-blind placebo controlled trial of a new serotonin uptake inhibitor, sertraline, in the treatment of obsessive-compulsive disorder. Psychopharmacol Bull. 1990;26:279–284.Google ScholarPubMed
36.Greist, JH, Jefferson, JW, Kobak, KA, et al. , A 1-year double-blind placebo-controlled fixed dose study of sertraline in the treatment of obsessive-compulsive disorder. Int Clin Psychopharmacol. 1995;10:57–65.CrossRefGoogle Scholar
37.Jenike, MA, Baer, L, Summergrad, P, Minichiello, WE, Holland, A, Seymour, R. Sertraline in obsessive-compulsive disorder: a double-blind comparison with placebo. Am J Psychiatry. 1990;147:923–928.Google ScholarPubMed
38.Kaye, NS, Dancu, C. Paroxetine and obsessive-compulsive disorder. Am J Psychiatry. 1994;151:1523.Google ScholarPubMed
39.Goodman, WK, Steiner, M, Bushnell, W, et al. , Efficacy of fixed doses of paroxetine in the treatment of obsessive-compulsive disorder: a randomized double-blind trial. J Clin Psychopharmacology. In press.Google Scholar
40.Hollander, E, Wong, CM. Obsessive-compulsive spectrum disorders. J Clin Psychiatry. 1995;56(suppl 4):3–6.Google ScholarPubMed
41.Phillips, KA, McElroy, SL, Hudson, JI, Pope, HG Jr.Body dysmorphic disorder: an obsessive-compulsive spectrum dis-order, a form of affective spectrum disorder, or both? J Clin Psychiatry. 1995;56 (suppl 4):41–52.Google Scholar
42.Hollander, E, Wong, CM. Body dysmorphic disorder, patho-logical gambling, and sexual compulsions. J CM Psychiatry. 1995;56;(suppl 4):7–13.Google Scholar
43.Flament, MF, Whitaker, A, Rapaport, JL. Obsessive compulsive disorder in adolescence: an epidemiological study. J Am Acad Child Adolesc Psychiatry. 1988;27:764–771.CrossRefGoogle ScholarPubMed
44.Apter, A, Ratzioni, G, King, R. Fluvoxamine open label treatment of adolescent in-patients with obsessive compulsive disorder or depression. J Am Acad Child Adolesc Psychiatry. 1994;33:342–348.CrossRefGoogle ScholarPubMed
45.Riddle, MA, Hardin, MT, King, R, Scahill, L, Woolston, JL. Fluoxetine treatment of obsessions and compulsions in patients with Tourette's syndrome. Am J Psychiatry. 1988;145:1173–1174.Google ScholarPubMed
46.Dominguez, RA, Mestre, SM. Management of treatment-refractory obsessive compulsive disorder patients. J Clin Psychiatry. 1994;55: (suppl 10):86–92.Google ScholarPubMed
47.Van Balkom, AJLM, Van Oppen, P, Vermeulen, AWA, Van Dyck, R, Nauta, MCE, Vorst, HCM. A meta-analysis on the treatment of obsessive compulsive disorder: a comparison of antidepressants, behavior, and cognitive therapy. Clin Psychol Rev. 1994;14:359–381.CrossRefGoogle Scholar
48.Stein, DJ, Spadaccini, E, Hollander, E. Meta-analysis of pharmacotherapy trials for obsessive-compulsive disorder. Int Clin Psychopharmacol. 1995;10:11–18.CrossRefGoogle ScholarPubMed