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Binge eating disorder revisited: what’s new, what’s different, what’s next

Published online by Cambridge University Press:  14 June 2019

Leslie Citrome Open the ORCID record for Leslie Citrome [Opens in a new window]
Leslie Citrome*
Affiliation:
Department of Psychiatry and Behavioral Sciences, New York Medical College, Valhalla, NY, USA
*
*Address correspondence to: Leslie Citrome, 11 Medical Park Drive, Suite 106, Pomona, NY 10970, USA. Tel: + 1 845 362 2081. (Email: citrome@cnsconsultant.com).
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Abstract

Binge eating disorder (BED) is the most common type of eating disorder. According to the most recent data available, the estimated lifetime prevalence of BED among US adults in the general population is 0.85% (men 0.42% and women 1.25%). Among psychiatric treatment populations, prevalence is several-fold higher. Although many people with BED are obese (BMI ≥ 30 kg/m2), roughly half are not. In the DSM-5, BED is defined by recurrent episodes of binge eating (eating in a discrete period of time, an amount of food larger than most people would eat in a similar amount of time under similar circumstances and a sense of lack of control over eating during the episode), occurring on average at least once a week for 3 months, and associated with marked distress. BED often goes unrecognized and thus untreated; in one study, 344 of 22,387 (1.5%) survey respondents met DSM-5 criteria for BED, but only 11 out of the 344 had ever been diagnosed with BED by a health-care provider. Psychiatric comorbidities are very common, with most adults with BED also experiencing anxiety disorders, mood disorders, impulse control disorders, or substance use disorders, suggesting that clinicians have patients in their practice with unrecognized BED. Multiple neurobiological explanations have been suggested for BED, including dysregulation in reward center and impulse control circuitry. Additionally, there is interplay between genetic influences and environmental stressors. Psychological treatments such as cognitive behavioral interventions have been recommended as first line and are supported by meta-analytic reviews; however, access to such treatments may be limited because of local availability and/or cost, and these treatments generally lead to little to no weight loss, although successfully eliminating binge eating can protect against future weight gain. Routine medication treatments for anxiety and depression do not necessarily ameliorate the symptoms of BED, but there are approved and emerging medication options, lisdexamfetamine and dasotraline, respectively, that specifically address the core drivers behind binge eating, namely obsessive thoughts and compulsive behaviors regarding food, resulting in marked decreases in binge eating behaviors as well as weight loss.

Keywords

Binge eating disordercognitive-behavioral therapydasotralineinter-personal therapylisdexamfetamine
Type
CME Review Article
Information
CNS Spectrums , Volume 24 , Issue S1: CME SUPPLEMENT , August 2019 , pp. 4 - 13
Copyright
© Cambridge University Press 2019 

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Footnotes

This activity is supported by an unrestricted educational grant from Sunovion Pharmaceuticals.

An addendum has been issued for this article, please see DOI: https://doi.org/10.1017/S1092852919001366.

References

REFERENCES

American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 5th ed. Arlington, VA: American Psychiatric Association; 2013.Google Scholar
Citrome, L. Lisdexamfetamine for binge eating disorder in adults: a systematic review of the efficacy and safety profile for this newly approved indication ‐ what is the number needed to treat, number needed to harm and likelihood to be helped or harmed? Int J Clin Pract. 2015; 69(4): 410–421.CrossRefGoogle ScholarPubMed
Ward, K, Citrome, L. Lisdexamfetamine: chemistry, pharmacodynamics, pharmacokinetics, and clinical efficacy, safety, and tolerability in the treatment of binge eating disorder. Expert Opin Drug Metab Toxicol. 2018; 14(2): 229–238.CrossRefGoogle ScholarPubMed
Citrome, L. A primer on binge eating disorder diagnosis and management. CNS Spectr. 2015; 20(Suppl 1): 44–50.CrossRefGoogle ScholarPubMed
Hudson, JI, Hiripi, E, Pope, HG, et al. The prevalence and correlates of eating disorder in the National Comorbidity Survey Replication. Biol Psychiatry. 2007; 61(3): 348–358.CrossRefGoogle ScholarPubMed
Kessler, RC, Berglund, PA, Chiu, WT, et al. The prevalence and correlates of binge eating disorder in the World Health Organization World Mental Health Surveys. Biol Psychiatry. 2013; 73(9): 904–914.CrossRefGoogle ScholarPubMed
Udo, T, Grilo, CM. Prevalence and correlates of DSM-5-defined eating disorders in a nationally representative sample of U.S. adults. Biol Psychiatry. 2018; 84(5): 345–354.CrossRefGoogle Scholar
Udo, T, Grilo, CM. Psychiatric and medical correlates of DSM-5 eating disorders in a nationally representative sample of adults in the United States. Int J Eat Disord. 2019; 52(1): 42–50.CrossRefGoogle Scholar
Carr, MM, Lydecker, JA, White, MA, et al. Examining physical activity and correlates in adults with healthy weight, overweight/obesity, or binge-eating disorder. Int J Eat Disord. 2019; 52(2): 159–165.CrossRefGoogle ScholarPubMed
Wilson, GT. Treatment of binge eating disorder. Psychiatr Clin North Am. 2011; 34(4): 773–783.CrossRefGoogle ScholarPubMed
Grilo, CM. Psychological and behavioral treatments for binge-eating disorder. J Clin Psychiatry. 2017; 78(Suppl 1): 20–24.CrossRefGoogle ScholarPubMed
Vocks, S, Tuschen-Caffier, B, Pietrowsky, R, et al. Meta-analysis of the effectiveness of psychological and pharmacological treatments for binge eating disorder. Int J Eat Disord. 2010; 43(3): 205–217.Google ScholarPubMed
Linardon, J, Messer, M, Fuller-Tyszkiewicz, M. Meta-analysis of the effects of cognitive-behavioral therapy for binge-eating-type disorders on abstinence rates in nonrandomized effectiveness studies: comparable outcomes to randomized, controlled trials? Int J Eat Disord. 2018; 51(12): 1303–1311.CrossRefGoogle ScholarPubMed
Hilbert, A, Petroff, D, Herpertz, S, et al. Meta-analysis of the efficacy of psychological and medical treatments for binge-eating disorder. J Consult Clin Psychol. 2019; 87(1): 91–105.CrossRefGoogle ScholarPubMed
Linardon, J. Rates of abstinence following psychological or behavioral treatments for binge-eating disorder: meta-analysis. Int J Eat Disord. 2018; 51(8): 785–797.CrossRefGoogle ScholarPubMed
Ghaderi, A, Odeberg, J, Gustafsson, S, et al. Psychological, pharmacological, and combined treatments for binge eating disorder: a systematic review and meta-analysis. Peer J. 2018; 6: e5113.CrossRefGoogle ScholarPubMed
Peat, CM, Berkman, ND, Lohr, KN, et al. Comparative effectiveness of treatments for binge-eating disorder: systematic review and network meta-analysis. Eur Eat Disord Rev. 2017; 25(5): 317–328.CrossRefGoogle ScholarPubMed
Brownley, KA, Berkman, ND, Peat, CM, et al. Binge-eating disorder in adults: a systematic review and meta-analysis. Ann Intern Med. 2016; 165(6): 409–420.CrossRefGoogle ScholarPubMed
Grilo, CM, Crosby, RD, Masheb, RM, et al. Overvaluation of shape and weight in binge eating disorder, bulimia nervosa, and sub-threshold bulimia nervosa. Behav Res Ther. 2009; 47(8): 692–696.CrossRefGoogle ScholarPubMed
Wang, SB, Jones, PJ, Dreier, M, et al. Core psychopathology of treatment-seeking patients with binge-eating disorder: a network analysis investigation. Psychol Med. 2018: 1–6. doi: 10.1017/S0033291718002702.CrossRefGoogle Scholar
Wilfley, DE, Citrome, L, Herman, BK. Characteristics of binge eating disorder in relation to diagnostic criteria. Neuropsychiatr Dis Treat. 2016; 12: 2213–2223.CrossRefGoogle ScholarPubMed
Herman, BK, Safikhani, S, Hengerer, D, et al. The patient experience with DSM-5-defined binge eating disorder: characteristics, barriers to treatment, and implications for primary care physicians. Postgrad Med. 2014; 126(5): 52–63.CrossRefGoogle ScholarPubMed
Lydecker, JA, Grilo, CM. I didn’t want them to see: secretive eating among adults with binge-eating disorder. Int J Eat Disord. 2019; 52(2): 153–158.CrossRefGoogle ScholarPubMed
Herman, BK, Deal, LS, DiBenedetti, DB, et al. Development of the 7-Item Binge-Eating Disorder Screener (BEDS-7). Prim Care Companion CNS Disord. 2016; 18(2). doi: 10.4088/PCC.15m01896.Google Scholar
Herman, BK, Deal, LS, Kando, JC, et al. Use and value of the 7-item binge eating disorder screener in clinical practice. Prim Care Companion CNS Disord. 2017; 19(3). doi: 10.4088/PCC.16m02075.CrossRefGoogle ScholarPubMed
Citrome, L. Binge-eating disorder and comorbid conditions: differential diagnosis and implications for treatment. J Clin Psychiatry. 2017; 78(Suppl 1): 9–13.CrossRefGoogle ScholarPubMed
Hamburger, WW. Emotional aspects of obesity. Med Clin North Am. 1951; 35(2): 483–499.CrossRefGoogle ScholarPubMed
Stunkard, AJ. Eating patterns and obesity. Psychiatr Q. 1959; 33: 284–295.CrossRefGoogle ScholarPubMed
American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 3rd ed. Washington, DC: American Psychiatric Association; 1980.Google Scholar
Yanovski, SZ. Binge eating disorder: current knowledge and future directions. Obes Res. 1993; 1(4): 306–324.Google ScholarPubMed
Grace, PS, Jacobson, RS, Fullager, CJ. A pilot comparison of purging and non-purging bulimics. J Clin Psychol. 1985; 41(2): 173–180.3.0.CO;2-N>CrossRefGoogle ScholarPubMed
American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 3rd ed., revised. Washington, DC: American Psychiatric Association; 1987.Google Scholar
Spitzer, RL, Devlin, MJ, Walsh, BT, et al. Binge eating disorder: to be or not to be in DSM-IV. Int J Eat Disord. 1991; 10(6): 627–629.3.0.CO;2-4>CrossRefGoogle Scholar
Spitzer, RL, Devlin, MJ, Walsh, BT, et al. Binge eating disorder: a multisite field trial of the diagnostic criteria. Int J Eat Disord. 1991; 11(3): 191–203.3.0.CO;2-S>CrossRefGoogle Scholar
Spitzer, RL, Yanovski, S, Wadden, T, et al. Binge eating disorder: its further validation in a multisite study. Int J Eat Disord. 1993; 13(2): 137–153.Google Scholar
American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 4th ed. Washington, DC: American Psychiatric Association; 1994.Google Scholar
American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 4th ed., text revision. Washington, DC: American Psychiatric Association; 2000.Google Scholar
Fairburn, CG, Bohn, K. Eating disorder NOS (EDNOS): an example of the troublesome “not otherwise specified” (NOS) category in DSM-IV. Behav Res Ther. 2005; 43(6): 691–701.CrossRefGoogle ScholarPubMed
Citrome, L, Kando, JC, Bliss, C. Relationships between clinical scales and binge eating days in adults with moderate to severe binge eating disorder in two phase III studies. Neuropsychiatr Dis Treat. 2018; 14: 537–546.CrossRefGoogle ScholarPubMed
Schienle, A, Schäfer, A, Hermann, A, et al. Binge-eating disorder: reward sensitivity and brain activation to images of food. Biol Psychiatry. 2009; 65(8): 654–661.CrossRefGoogle ScholarPubMed
Balodis, IM, Molina, ND, Kober, H, et al. Divergent neural substrates of inhibitory control in binge eating disorder relative to other manifestations of obesity. Obesity (Silver Spring). 2013; 21(2): 367–377.CrossRefGoogle ScholarPubMed
Schäfer, A, Vaitl, D, Schienle, A. Regional grey matter volume abnormalities in bulimia nervosa and binge-eating disorder. Neuroimage. 2010; 50(2): 639–643.CrossRefGoogle ScholarPubMed
Davis, C, Levitan, RD, Yilmaz, Z, et al. Binge eating disorder and the dopamine D2 receptor: genotypes and sub-phenotypes. Prog Neuropsychopharmacol Biol Psychiatry. 2012; 38(2): 328–335.CrossRefGoogle ScholarPubMed
Wang, GJ, Geliebter, A, Volkow, ND, et al. Enhanced striatal dopamine release during food stimulation in binge eating disorder. Obesity (Silver Spring). 2011; 19(8): 1601–1608.CrossRefGoogle ScholarPubMed
Heal, DJ, Hallam, M, Prow, M, et al. Dopamine and μ-opioid receptor dysregulation in the brains of binge-eating female rats ‐ possible relevance in the psychopathology and treatment of binge-eating disorder. J Psychopharmacol. 2017; 31(6): 770–783.CrossRefGoogle ScholarPubMed
Nathan, PJ, Bullmore, ET. From taste hedonics to motivational drive: central μ-opioid receptors and binge-eating behaviour. Int J Neuropsychopharmacol. 2009; 12(7): 995–1008.CrossRefGoogle ScholarPubMed
Davis, CA, Levitan, RD, Reid, C, et al. Dopamine for “wanting” and opioids for “liking”: a comparison of obese adults with and without binge eating. Obesity (Silver Spring). 2009; 17(6): 1220–1225.Google ScholarPubMed
Davis, C. The epidemiology and genetics of binge eating disorder (BED). CNS Spectr. 2015; 20(6): 522–529.CrossRefGoogle Scholar
Trace, SE, Baker, JH, Peñas-Lledó, E, et al. The genetics of eating disorders. Annu Rev Clin Psychol. 2013; 9: 589–620.CrossRefGoogle ScholarPubMed
Pike, KM, Wilfley, D, Hilbert, A, et al. Antecedent life events of binge-eating disorder. Psychiatry Res. 2006; 142(1): 19–29.CrossRefGoogle ScholarPubMed
Halmi, KA. Perplexities of treatment resistance in eating disorders. BMC Psychiatry. 2013; 13: 292.CrossRefGoogle ScholarPubMed
Cossrow, N, Pawaskar, M, Witt, EA, et al. Estimating the prevalence of binge eating disorder in a community sample from the United States: comparing DSM-IV-TR and DSM-5 criteria. J Clin Psychiatry. 2016; 77(8): e968–e974.CrossRefGoogle Scholar
Citrome, L. Food for thought: do you ask about eating? Int J Clin Pract. 2016; 70(7): 516–517.CrossRefGoogle Scholar
Lydecker, JA, Galbraith, K, Ivezaj, V, et al. Words will never hurt me? Preferred terms for describing obesity and binge eating. Int J Clin Pract. 2016; 70(8): 682–690.CrossRefGoogle Scholar
Citrome, L. More food for thought: preferred words. Int J Clin Pract. 2016; 70(8): 640.CrossRefGoogle ScholarPubMed
Kornstein, SG, Keck, PE Jr, Herman, BK, et al. Communication between physicians and patients with suspected or diagnosed binge eating disorder. Postgrad Med. 2015; 127(7): 661–670.CrossRefGoogle ScholarPubMed
Wilson, GT, Grilo, CM, Vitousek, KM. Psychological treatment of eating disorders. Am Psychol. 2007; 62(3): 199–216.CrossRefGoogle ScholarPubMed
Wilfley, DE, Agras, WS, Telch, CF, et al. Group cognitive-behavioral therapy and group interpersonal psychotherapy for the nonpurging bulimic individual: a controlled comparison. J Consult Clin Psychol. 1993; 61(2): 296–305.CrossRefGoogle ScholarPubMed
Wilfley, DE, Welch, RR, Stein, RI, et al. A randomized comparison of group cognitive-behavioral therapy and group interpersonal psychotherapy for the treatment of overweight individuals with binge-eating disorder. Arch Gen Psychiatry. 2002; 59(8): 713–721.CrossRefGoogle ScholarPubMed
Reas, DL, Grilo, CM. Pharmacological treatment of binge eating disorder: update review and synthesis. Expert Opin Pharmacother. 2015; 16(10): 1463–1478.CrossRefGoogle ScholarPubMed
Reas, DL, Grilo, CM. Current and emerging drug treatments for binge eating disorder. Expert Opin Emerg Drugs. 2014; 19(1): 99–142.CrossRefGoogle ScholarPubMed
McElroy, SL, Guerdjikova, AI, Mori, N, et al. Pharmacological management of binge eating disorder: current and emerging treatment options. Ther Clin Risk Manag. 2012; 8: 219–241.CrossRefGoogle ScholarPubMed
Reas, DL, Grilo, CM. Review and meta-analysis of pharmacotherapy for binge-eating disorder. Obesity (Silver Spring) 2008; 16(9): 2024–2038.CrossRefGoogle ScholarPubMed
Shire. VYVANSE (lisdexamfetamine dimesylate) capsules, for oral use, CII. Prescribing information. Revised January 2018. http://pi.shirecontent.com/PI/PDFs/Vyvanse_USA_ENG.pdf. Accessed March 1, 2019.Google Scholar
McElroy, SL, Hudson, JI, Mitchell, JE, et al. Efficacy and safety of lisdexamfetamine for treatment of adults with moderate to severe binge-eating disorder: a randomized clinical trial. JAMA Psychiatry. 2015; 72(3): 235–246.CrossRefGoogle ScholarPubMed
McElroy, SL, Hudson, J, Ferreira-Cornwell, MC, et al. Lisdexamfetamine dimesylate for adults with moderate to severe binge eating disorder: results of two pivotal phase 3 randomized controlled trials. Neuropsychopharmacology. 2016; 41(5): 1251–1260.CrossRefGoogle ScholarPubMed
Deal, LS, Wirth, RJ, Gasior, M, et al. Validation of the yale-brown obsessive compulsive scale modified for binge eating. Int J Eat Disord. 2015; 48(7): 994–1004.CrossRefGoogle ScholarPubMed
McElroy, SL, Hudson, JI, Gasior, M, et al. Time course of the effects of lisdexamfetamine dimesylate in two phase 3, randomized, double-blind, placebo-controlled trials in adults with binge-eating disorder. Int J Eat Disord. 2017; 50(8): 884–892.CrossRefGoogle ScholarPubMed
Kornstein, SG, Bliss, C, Kando, J, et al. Clinical characteristics and treatment response to lisdexamfetamine dimesylate versus placebo in adults with binge eating disorder: analysis by gender and age. J Clin Psychiatry. 2019; 80(2): 18m12378. doi: 10.4088/JCP.18m12378.CrossRefGoogle ScholarPubMed
Sheehan, DV, Gasior, M, McElroy, SL, et al. Effects of lisdexamfetamine dimesylate on functional impairment measured on the sheehan disability scale in adults with moderate-to-severe binge eating disorder: results from two randomized, placebo-controlled trials. Innov Clin Neurosci. 2018; 15(5–6): 22–29.Google ScholarPubMed
Citrome, L. Compelling or irrelevant? Using number needed to treat can help decide. Acta Psychiatr Scand. 2008; 117(6): 412–419.CrossRefGoogle ScholarPubMed
Citrome, L. Relative vs. absolute measures of benefit and risk: what’s the difference? Acta Psychiatr Scand. 2010; 121(2): 94–102.CrossRefGoogle ScholarPubMed
Citrome, L, Ketter, TA. When does a difference make a difference? Interpretation of number needed to treat, number needed to harm, and likelihood to be helped or harmed. Int J Clin Pract. 2013; 67(5): 407–411.CrossRefGoogle ScholarPubMed
Hudson, JI, McElroy, SL, Ferreira-Cornwell, MC, et al. Efficacy of lisdexamfetamine in adults with moderate to severe binge-eating disorder: a randomized clinical trial. JAMA Psychiatry. 2017; 74(9): 903–910.CrossRefGoogle ScholarPubMed
Gasior, M, Hudson, J, Quintero, J, et al. A phase 3, multicenter, open-label, 12-month extension safety and tolerability trial of lisdexamfetamine dimesylate in adults with binge eating disorder. J Clin Psychopharmacol. 2017; 37(3): 315–322.CrossRefGoogle ScholarPubMed
Chen, YL, Skende, E, Lin, J, et al. Absorption, distribution, metabolism, and excretion of [14C]-dasotraline in humans. Pharmacol Res Perspect. 2016; 5(1): e00281.CrossRefGoogle Scholar
Koblan, KS, Hopkins, SC, Sarma, K, et al. Assessment of human abuse potential of dasotraline compared to methylphenidate and placebo in recreational stimulant users. Drug Alcohol Depend. 2016; 159: 26–34.CrossRefGoogle ScholarPubMed
Navia, B, Hudson, JI, McElroy, SL, et al. Dasotraline for the treatment of moderate to severe binge eating disorder in adults: results from a randomized, double-blind, placebo-controlled trial. Poster P7-084, presented at the 170th Annual Meeting of the American Psychiatric Association; May 20–24, 2017; San Diego, CA, USA.Google Scholar
Navia, B, Hudson, JI, McElroy, SL, et al. Dasotraline for treatment of adults with binge-eating disorder: effect on behavioral outcomes. Poster W45, presented at the Annual Meeting of the American Society for Clinical Psychopharmacology; May 29–June 1, 2018; Miami Beach, FL, USA.Google Scholar
Goldman, R, Hudson, JI, McElroy, SL, et al. Efficacy and safety of dasotraline in adults with binge-eating disorder: a randomized, double-blind, fixed-dose trial. Poster M55, presented at the Annual Meeting of the American College of Neuropsychopharmacology; December 9–13, 2018; Hollywood, FL, USA.Google Scholar
Citrome, L. Return to the planet of the apps. Int J Clin Pract. 2018; 72(9): e13241.CrossRefGoogle ScholarPubMed
Tregarthen, JP, Lock, J, Darcy, AM. Development of a smartphone application for eating disorder self-monitoring. Int J Eat Disord. 2015; 48(7) :972–982.CrossRefGoogle ScholarPubMed
Kim, JP, Sadeh-Sharvit, S, Darcy, AM, et al. The utility and acceptability of a self-help smartphone application for eating disorder behaviors. J Technol Behav Sci. 2018; 3(3): 161–164.CrossRefGoogle ScholarPubMed
Lindgreen, P, Lomborg, K, Clausen, L. Patient experiences using a self-monitoring app in eating disorder treatment: qualitative study. JMIR Mhealth Uhealth. 2018; 6(6): e10253.CrossRefGoogle ScholarPubMed
Hildebrandt, T, Michaelides, A, Mackinnon, D, et al. Randomized controlled trial comparing smartphone assisted versus traditional guided self-help for adults with binge eating. Int J Eat Disord. 2017; 50(11): 1313–1322.CrossRefGoogle ScholarPubMed
Juarascio, AS, Manasse, SM, Goldstein, SP, et al. Review of smartphone applications for the treatment of eating disorders. Eur Eat Disord Rev. 2015; 23(1): 1–11.CrossRefGoogle ScholarPubMed
Fairburn, CG, Rothwell, ER. Apps and eating disorders: a systematic clinical appraisal. Int J Eat Disord. 2015; 48(7): 1038–1046.CrossRefGoogle ScholarPubMed