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Early Onset Obsessive-Compulsive Disorder With and Without Tics

Published online by Cambridge University Press:  07 November 2014

Maria Alice de Mathis ,
Juliana B. Diniz ,
Roseli G. Shavitt ,
Albina R. Torres ,
Ygor A. Ferrão ,
Victor Fossaluza ,
Carlos Pereira ,
Eurípedes C. Miguel  and
Maria Conceição do Rosario
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Abstract

Introduction: Research suggests that obsessive-compulsive disorder (OCD) is not a unitary entity, but rather a highly heterogeneous condition, with complex and variable clinical manifestations.

Objective: The aims of this study were to compare clinical and demographic characteristics of OCD patients with early and late age of onset of obsessive-compulsive symptoms (OCS); and to compare the same features in early onset OCD with and without tics. The independent impact of age at onset and presence of tics on comorbidity patterns was investigated.

Methods: Three hundred and thirty consecutive outpatients meeting Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition criteria for OCD were evaluated: 160 patients belonged to the “early onset” group (EOG): before 11 years of age, 75 patients had

Results: The EOG had a predominance of males, higher frequency of family history of OCS, higher mean scores on the “aggression/violence” and “miscellaneous” dimensions, and higher mean global DY-BOCS scores. Patients with EOG without tic disorders presented higher mean global DY-BOCS scores and higher mean scores in the “contamination/cleaning” dimension.

Conclusion: The current results disentangle some of the clinical overlap between early onset OCD with and without tics.

Type
Original Research
Information
CNS Spectrums , Volume 14 , Issue 7 , July 2009 , pp. 362 - 370
Copyright
Copyright © Cambridge University Press 2009

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References

REFERENCES

1.McKay, D, Abramowitz, JS, Calamari, JE, et al.A critical evaluation of obsessive-compulsive disorder subtypes: symptoms versus mechanisms. Clin Psychol Rev. 2004;24:283–313.Google Scholar
2.Miguel, EC, Leckman, JF, Rauch, S, et al.Obsessive-compulsive disorder phenotypes: implications for genetic studies. Mol Psychiatry. 2005;10:258–275.CrossRefGoogle ScholarPubMed
3.Rosário-Campos, MC, Leckman, JF, Mercadante, MT, et al.Adults with early-onset obsessive-compulsive disorder. Am J Psychiatry. 2001;158:1899–1903.Google Scholar
4.Diniz, JB, Rosário-Campos, MC; Hounie, AG, et al.Chronic tics and Tourette syndrome in patients with obsessive–compulsive disorder. J Psychiatr Res. 2006;40:487–493.Google Scholar
5.Torresan, RC, Ramos-Cerqueira, AT, de Mathis, MA, et al.Sex differences in the phenotypic expression of obsessive-compulsive disorder: an exploratory study from Brazil. Compr Psychiatry. 2009;50:63–69. Epub 2008 Aug 29.Google Scholar
6.Ginsburg, GS, Kingery, JN, Drake, KL, Grados, MA. Predictors of treatment response in pediatric obsessive-compulsive disorder. J Am Acad Child Adolesc Psychiatry. 2008;47:868–878.Google Scholar
7.Mercadante, MT, Busatto, GF, Lombroso, PJ, et al.The psychiatric symptoms of rheumatic fever. Am J Psychiatry. 2000;157:2036–2038.Google Scholar
8.de Mathis, MA, Diniz, JB, do Rosário, MC, et al.What is the optimal way to subdivide obsessive-compulsive disorder? CNS Spectr. 2006;11:762–768, 771–774, 776–779.Google Scholar
9.Miguel, EC, Rauch, SL, Jenike, MA. Obsessive-compulsive Disorder. Psychiatric Clin North Am. 1997;20:863–883.CrossRefGoogle ScholarPubMed
10.Holzer, JC, Goodman, WK, McDougle, CJ, et al.Obsessive-compulsive disorder with and without a chronic tic disorder. A comparison of symptoms in 70 patients. Br J Psychiatry. 1994;164:469–473.CrossRefGoogle ScholarPubMed
11.Leckman, JF, Grice, DE, Barr, LC, et al.Tic-related versus non-tic-related obsessive compulsive disorder. Anxiety. 1994–1995;1:208–215.Google Scholar
12.Leckman, JF, Goodman, WK, North, WG, et al.The role of central oxytocin in obsessive compulsive disorder and related normal behavior. Psychoneuroendocrinology. 1994 19:723–749.Google Scholar
13.Miguel, EC, Coffey, BJ, Baer, L, et al.Phenomenology of intentional repetitive behaviors in obsessive-compulsive disorder and Tourette's syndrome. J Clin Psychiatry. 1995;46:246–255.Google Scholar
14.Miguel, EC, Rauch, SL, Jenike, MA. Obsessive-compulsive disorder. Psychiatr Clin North Am. 1997;20:863–883.Google Scholar
15.Miguel, EC, do Rosário-Campos, MC, Shavitt, RG, Hounie, AG, Mercadante, MT. Tic-related obsessive-compulsive disorder phenotype. Adv Neurol. 2001;85:43–55.Google Scholar
16.Eapen, V, O'Neill, J, Gurling, HM, et al.Sex of parent transmission effect in Tourette's syndrome: evidence for earlier age at onset in maternally transmitted cases suggests a genomic imprinting effect. Neurology. 1997;48:934–937.Google Scholar
17.Petter, T, Richter, MA, Sandor, P. Clinical features distinguishing patients with Tourette's syndrome and obsessive-compulsive disorder from patients with obsessive-compulsive disorder without tics. J Clin Psychiatry. 1998;59:456–459.Google Scholar
18.Tukel, R, Ertekin, E, Batmaz, S, et al.Influence of age at onset on clinical feature's in obsessive-compulsive disorder. Depress Anxiety. 2005;21:112–117.CrossRefGoogle ScholarPubMed
19.Pauls, DL, Leckman, JF, Towbin, KE, et al.A possible genetic relationship exists between Tourett's syndrome and obsessive-compulsive disorder. Psychopharmacol Bull. 1986; 22:730–733.Google Scholar
20.Comings, DE, Comings, BG. Hereditary agoraphobia and obsessive-compulsive behaviour in relatives of patients with Gilles de la Tourette's syndrome. Br J Psychiatry. 1987;151:195–199.Google Scholar
21.Robertson, MM, Trimble, MR, Lees, AJ. The psychopathology of the Gilles de la Tourette syndrome. A phenomenological analysis. Br J Psychiatry. 1988;152:383–390.Google Scholar
22.Eapen, V, Pauls, DL, Robertson, MM. Evidence for autsomal dominant transmission in Tourette's syndrome. United Kingdom cohort study. Br J Psychiatry. 1993;162:593–596.Google Scholar
23.Rosário-Campos, MC, Leckman, J, Curi, M, et al.A family study of early obsessive-compulsive disorder. Am J Med Genet B Neuropsychiatr Genet. 2005;136:92–97.Google Scholar
24.Hanna, GL, Hilme, JA, Curtis, GC, Gillespie, BW. A family study of obsessive-compulsive disorder with pediatric probands. Am J Med Genet B Neuropsychiatr Genet. 2005;134B:13–19.Google Scholar
25.Hanna, GL, Veenstra-VanderWeele, J, Cox, NJ, et al.Genome-wide linkage analysis of families with obsessive-compulsive disorder ascertained through pediatric probands. Am J Med Genet. 2002;114:230–234.Google Scholar
26.Scahill, L, Kano, Y, King, RA, et al.Influence of age and tic disorders on obsessive-compulsive disorder in a pediatric sample. J Child Adolesc Psychopharmacol. 2003;13(Suppl 1):S7–S17.Google Scholar
27.de Mathis, MA, do Rosario, MC, Diniz, JB, et al.Obsessive-compulsive disorder: influence of age at onset on comorbidity patterns. Eur Psychiatry. 2008;23:187–194.Google Scholar
28.Geller, D, Biederman, J, Jones, J, et al.Is juvenile obsessive-compulsive disorder a developmental subtype of the disorder? A review of pediatric literature. J Am Acad Child Adolesc Psychiatry. 1998;37:420–427.Google Scholar
29.Goodman, WK, Price, LH, Rasmussem, SA, et al.The Yale-Brown obsessive-compulsve scale: I development and reliability. Arch Gen Psychiatry. 1989;46:1006–1011.Google Scholar
30.Rosário-Campos, MC, Miguel, EC, Quatrano, S, et al.The Dimensional Yale-Brown Obsessive-Compulsive Scale (DY-BOCS): an instrument for assessing obsessive-compulsive symptom dimensions. Mol Psychiatry. 2006;11:495–504.Google Scholar
31.Leckman, JF, Riddle, MA, Hardin, MT. The Yale Global Tic Severity Scale: initial testing of a clinician-rated scale of tic severity. J Am Acad Chld Adolesc Psychatry. 1989;8:566–573.Google Scholar
32.First, MB, Spitzer, RL, Gibbon, M, Willians, JBW. Structured Clinical Interview for DSM-IV Axis I Disorders-Patient Edition. Version 2.0. Biometric Research Department, New York, NY; New York State Psychiatric Institute: 1995.Google Scholar
33.Pereira, CAB, Stern, JM. Evidence and Credibility: Full Bayesian Significance Test for Precise Hypotheses. Entropy. 1999;1:99–110.Google Scholar
34.Riddle, MA, Scahill, L, King, R, et al.Obsessive compulsive disorder in children and adolescents: phenomenology and family history. J Am Acad Child Adolesc Psychiatry. 1990;29:766–772.Google Scholar
35.Leckman, JF, Grice, DE, Boardman, J, et al.Symptoms of obsessive-compulsive disorder. Am J Psychiatry. 1997;154:911–917.Google Scholar
36.Zohar, AH, Pauls, DL, Ratzoni, G, et al.Obsessive-compulsive disorder with and without tics in an epidemiological sample of adolescents. Am J Psychiatry. 1997;154:274–276.Google Scholar
37.Fontenelle, LF, Mendlowicz, MV, Marques, C, Versiani, M. Early- and late-onset obsessive-compulsive disorder in adult patients: an exploratory clinical and therapeutic study. J Psychiatr Res. 2003;37:127–133. Erratum in: J Psychiatr Res. 2003;37:263.Google Scholar
38.Jaisoorya, TS, Janardhan Reddy, YC, Srinath, S. Is juvenile obsessive-compulsive disorder a developmental subtype of the disorder? Findings from an Indian study. Eur Child Adolesc Psychiatry. 2003;12:290–297.Google Scholar
39.Pauls, DL, Alsobrook|, JP 2nd.Goodman, W, et al.A family study of obsessive-compulsive disorder. Am J Psychiatry. 1995;152:76–84.Google ScholarPubMed
40.Nestadt, GI, Samuels, J, Riddle, M, et al.A family study of obsessive-compulsive disorder. Arch Gen Psychiatry. 2000;57:573–580.Google Scholar
41.Besiroglu, L, Uguz, F, Saglam, M, Agargun, MY, Cilli, AS. Factors associated with major depressive disorder occurring after the onset of obsessive-compulsive disorder. J Affect Disord. 2007;102:73–79.Google Scholar
42.Hasler, G, Pinto, A, Greenberg, BD, et al; OCD Collaborative Genetics Study. Familiality of factor analysis-derived YBOCS dimensions in OCD-affected sibling pairs from the OCD Collaborative Genetics Study. Biol Psychiatry. 2007;61:617–625.Google Scholar
43.George, MS, Trimble, MR, Ring, HA, Sallee, FR, Robertson, MM. Obsessions in obsessive-compulsive disorder with and without Gilles de la Tourette's syndrome. Am J Psychiatry. 1993;150:93–97.Google Scholar
44.de Groot, CM, Bornstein, RA, Baker, GB. Obsessive-compulsive symptom clusters and urinary amine correlates in Tourette syndrome. J Nerv Ment Dis. 1995;183:224–230.Google Scholar
45.Cath, DC, Spinhoven, P, van de Wetering, BJ, et al.The relationship between types and severity of repetitive behaviors in Gilles de la Tourette's disorder and obsessive-compulsive disorder. J Clin Psychiatry. 2000;61:505–513.CrossRefGoogle ScholarPubMed
46.Cameron, OG, Hill, EM. Women and anxiety. Psychiatr Clin North Am. 1989;12:175–186.Google Scholar
47.Fahy, TA, Osacar, A, Marks, I. History of eating disorders in female patients with obsessive-compulsive disorder. Int J Eat Dis. 1993;14:439–443.Google Scholar
48.Rosario-Campos, MC. Transtorno Obsessivo-Compulsivo de Início Precoce e Iníciotardio: Características Clínicas, Psicopatológicas e de Comorbidade [dissertação]. [in Portugese]. São Paulo, Brazil: Faculdade de Medicina da Universidade de São Paulo; 1998.Google Scholar
49.Ferrão, YA, Shavitt, RG, Bedin, NR, et al.Clinical features associated to refractory obsessive-compulsive disorder. J Affect Disord. 2006;94:199–209.Google Scholar
50.Ackerman, DL, Greenland, S, Bystritsky, A, Morgenstern, H, Katz, RJ. Predictors of treatment response in obsessive-compulsive disorder: multivariate analyses from a multicenter trial of clomipramine. J Clin Psychopharmacol. 1994;14:247–254.CrossRefGoogle ScholarPubMed
51.Ravizza, L, Barzega, G, Bellino, S, Bogetto, F, Maina, G. Predictors of drug treatment response in obsessive-compulsive disorder. J Clin Psychiatry. 1995;56:338–373.Google Scholar
52.Jenike, MA, Baer, L, Minichiello, WE, Rauch, SL, Buttolph, ML. Placebo-controlled trial of fluoxetine and phenelzine for obsessive-compulsive disorder. Am J Psychiatry. 1997;154:1261–1264.Google Scholar
53.Shavitt, RG, Belotto, C, Curi, M, et al.Clinical features associated with treatment response in obsessive-compulsive disorder. Compr Psychiatry. 2006;47:276–81. Epub 2006 Apr 19.Google Scholar
54.Jaisoorya, TS, Reddy, YC, Srinath, S, Thennarasu, K. Obsessive-compulsive disorder with and without tic disorder: a comparative study from India. CNS Spectr. 2008;13:705–711.Google Scholar