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The Effect of Smoking on Brainstem Auditory Evoked Potentials in Positive- and Negative-Symptom Schizophrenia

Published online by Cambridge University Press:  07 November 2014

Abstract

Studying brainstem auditory evoked potentials (BAEPs) and comparing the specific waves in smokers vs nonsmokers in both positive- and negative-symptom schizophrenia may elucidate the role of smoking in information processing. BAEPs were recorded in 40 patients with schizophrenia; 20 had predominantly positive symptoms (10 smokers and 10 nonsmokers) and 20 had predominantly negative symptoms (10 smokers and 10 nonsmokers). The severity of positive and negative symptoms was assessed by scale of assessment of positive symptoms and scale of assessment of negative symptoms (SANS). The BAEP results were compared with 15 healthy control individuals matched with the patients by age, sex, and cultural background. The smokers with negative symptoms showed a significant increase in the alogia, summary, and composite scores of SANS as compared to the nonsmokers. Although, most of the BAEP abnormalities were among patients with positive symptoms. The effect of smoking on the BAEPs was only in patients with negative symptoms.

We also studied the interaction between smoking factor (smokers vs nonsmokers) and group type (group with mostly positive symptoms vs group with mostly negative symptoms) on the BAEPs and found a significant difference only for the first-wave latency mainly on the right side (P=0.012). The absence of a significant effect of smoking on most of the parameters of the BAEPs on interaction with the group factor suggests that the effect of smoking on the BAEPs is more apparent when negative symptoms prevail. However, studies are warranted to substantiate this finding.

Type
Original Research
Copyright
Copyright © Cambridge University Press 2001

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References

REFERENCES

1.Hughes, JR, Hatsukami, DK, Mitchell, JL, Dahlgren, LA. Prevalence of smoking among psychiatric outpatients. Am J Psychiatry. 1986;143:993997.Google ScholarPubMed
2.Lohr, JB, Flynn, K. Smoking and schizophrenia. Schizophr Res. 1992;8:93102.CrossRefGoogle ScholarPubMed
3.Kessler, RC, McGonagle, KA, Zhao, S, et al.Lifetime and 12-month prevalence of DSM-III psychiatric disorders in the U.S.: results from the national comorbidity survey. Arch Gen Psychiatry. 1994;51:819.CrossRefGoogle ScholarPubMed
4.Glassman, AH, Heizer, JE, Covey, LS, et al.Smoking cessation and major depression. JAMA. 1990;264:15461549.CrossRefGoogle ScholarPubMed
5.Guterman, Y, Josiassen, RC. Sensory gating deviance in schizophrenia in the context of task related effects. J Psychophysiol. 1994;18:112.CrossRefGoogle ScholarPubMed
6.Igata, M, Ohta, M, Hayashida, Y, Abe, K. Missing peaks in auditory brain stem responses and negative symptoms in schizophrenia. Jpn J Psychiatry Neurol. 1994;48:571578.Google ScholarPubMed
7.Kumar, V, Tandon, OP. Brain stem auditory evoked potentials (BAEPs) in tobacco smokers. Indian J Physiol Pharmacol. 1996;40:381384.Google ScholarPubMed
8.Domino, EF, Kishimoto, T. Short and middle latency auditory evoked potentials in non-smokers and tobacco smokers. Electroencephalogr Clin Neurophysiol. 1999;49(suppl):3640.Google Scholar
9.Andreasen, NC. Comprehensive Assessment of Symptoms and History (CASH). Iowa City, IA: University of Iowa Press; 1987.Google Scholar
10.Diagnostic and Statistical Manual of Mental Disorders. 4th ed. Washington, DC: American Psychiatric Association; 1994.Google Scholar
11.Andreasen, NC. The Scale for Assessment of Positive Symptoms (SAPS). Iowa City, IA: University of Iowa Press; 1984.Google Scholar
12.Andreasen, NC. The Scale for the Assessment of Negative Symptoms (SANS). Iowa City, IA: University of Iowa Press; 1984.Google Scholar
13.Chiappa, KR. Brain stem auditory evoked potentials: methodology. In: Chiappa, KH, ed. Evoked Potentials in Clinical Medicine. 2nd ed. New York, NY: Raven Press; 1990:173284.Google Scholar
14.Lindstrom, LH, Klockhoff, I, Suedberg, A, Bergstrom, K. Abnormal brain stem auditory evoked response in hallucinating schizophrenic patients. Br J Psychiatry. 1987;151:919.CrossRefGoogle ScholarPubMed
15.Mubarak, A, Taher, G. Relationship of brain stem auditory evoked potentials to symptomatology of schizophrenia. Curr Psychiatry. 1996;3:231240.Google Scholar
16.Lyon, ER. A review of the effects of nicotine on schizophrenia and antipsychotic medications. Psychiatr Serv. 1999;50:13461350.CrossRefGoogle ScholarPubMed
17.Taiminen, TJ, Salokangas, RK, Saarijarvi, S, et al.Smoking and cognitive deficits in schizophrenia: a pilot study. Addict Behav. 1998;23:263266.CrossRefGoogle ScholarPubMed
18.Adler, LE, Olincy, A, Waldo, M, et al.Schizophrenia, sensory gating, and nicotinic receptors. Schizophr Bull. 1998;24:189202.CrossRefGoogle ScholarPubMed