Hostname: page-component-cd9895bd7-jkksz Total loading time: 0 Render date: 2024-12-25T19:31:43.370Z Has data issue: false hasContentIssue false
  • English
  • Français

Electroretinogram B-Wave Amplitude in Panic Disorder

Published online by Cambridge University Press:  07 November 2014

Paolo Castrogiovanni ,
Fulvio Pieraccini ,
Sonia Iapichino ,
Claudia Pacchierotti ,
Letizia Bossini ,
Elisabetta Truglia ,
Claudio Malpassi  and
Bruno Natale
Get access Rights & Permissions [Opens in a new window]

Abstract

Abnormal light-related behaviors have been described for patients with panic disorder (PD). The present study was undertaken to investigate the retinal light response in PD using electroretinography (ERG). The authors conducted bwave ERG measurements with a bright light (after dark adaptation) in 28 patients with PD and 28 control subjects. There were no significant differences in the mean b-wave amplitude between the two groups, but the retinal response to light in PD patients was generally lower than in healthy subjects. A large interindividual variability was found; also noted was a significant difference in the mean b-wave amplitude between the right and left eyes in the control group. The data indicate subtle variation of retinal photosensitivity in a subgroup of patients with PD. Because dopaminergic retinal activity affects b-ERG amplitude, the authors hypothesize that the dopaminergic system is involved in the response to light in PD patients.

Type
Feature Articles
Information
CNS Spectrums , Volume 6 , Issue 3: New Perspectives on Examining Neuropsychiatric Disorders , March 2001 , pp. 210 - 213
Copyright
Copyright © Cambridge University Press 2001

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

1.Symonds, RL, Williams, P. Seasonal variation in the incidence of mania. Br J Psychiatry. 1976;129:45–48.CrossRefGoogle ScholarPubMed
2.Rosenthal, NE, Sack, DA, Gillin, JC, et al.Seasonal affective disorder: a description of the syndrome and preliminary findings with light therapy. Arch Gen Psychiatry. 1984:41:72–80.CrossRefGoogle ScholarPubMed
3.Gerbaldo, H, Thaker, G. Sun gazing and photophilia in schizophrenia. Am J Psychiatry. 1991;148:693.Google ScholarPubMed
4.Kellner, M, Wiedemann, K, Zihl, J. Illumination perception in photophobic patients suffering from panic disorder with agoraphobia. Ada Psychiatr Scand. 1997;96:72–74.CrossRefGoogle ScholarPubMed
5.Marriott, P, Greenwood, KM, Armstrong, SM. Seasonality in panic disorder. J Affect Disord. 1994;31:75–80.CrossRefGoogle ScholarPubMed
6.Lepine, JP, Chignon, JM, Therani, M. Suicidal behaviour and onset of panic disorder. Arch Gen Psychiatry. 1991;48:668–669.CrossRefGoogle ScholarPubMed
7.Watts, FN, Wilkins, AJ. The role of provocative visual stimuli in agoraphobia. Psychol Med. 1989;19:875–885.CrossRefGoogle ScholarPubMed
8.Hazzell, J, Wilkins, AJ. A contribution of fluorescent lighting to agoraphobia. Psychol Med. 1990;20:591–596.CrossRefGoogle Scholar
9.Nichols, CW, Jacobowitz, D, Hottenstein, M. The influence of light and dark adaptation on the catecholamine content of the retina and choroid. Invest Ophthalmol. 1967;6:642–646.Google ScholarPubMed
10.Severs, MI, Johnson, MA. The variability of the b-wave of the electroretinogram with stimulus luminance. Doc Ophthalmol. 1993;84:291–299.CrossRefGoogle Scholar
11.Berson, EL. Electrical phenomena in the retina. In: Moses, RA, ed. Adler's Physiology of the Eye. St. Louis, Mo: Mosby; 1975:453–499.Google Scholar
12.Penn, RD, Hagins, WA. Signal transmission along retinal rods and the origin of the electroretinographic a-wave. Nature. 1969;223:201–204.CrossRefGoogle ScholarPubMed
13.Steinberg, RH, Schmidt, R, Brown, KT. Intracellular responses to light from cat pigment epithelium: origin of the electroretinogram c-wave. Nature. 1970;227:728–730.CrossRefGoogle ScholarPubMed
14.Niemeyer, G. Electrophysiological testing of the function of the vertebrate retina. Pharmacol Ther. 1979;5:593–598.CrossRefGoogle ScholarPubMed
15.Castrogiovanni, P, Marazziti, D. ERG b-wave amplitude and brain dopaminergic activity. Am J Psychiatry. 1989;146:1085–1086.Google ScholarPubMed
16.Filip, P, Balik, J. Possible indication of dopaminergic blockade in man by ERG. Intern Pharmacopsychiatry. 1978;13:151–158.CrossRefGoogle Scholar
17.Fornaro, P, Perossini, M, Placidi, GF, et al.Electroretinography (ERG) as a tool of investigation of dopaminergic activity in man. ERG changes induced by perphenazine and bromocriptine. Res Commun Psychol Psychiatr Behav. 1984;9:307–317.Google Scholar
18.Fornaro, P, Castrogiovanni, P, Perossini, M, et al.Electroretinography as a tool of investigation in human psychopharmacology: electroretinographic changes induced by a combination of carbidopa and levodopa. Acta Neurologica. 1980;2:293–299.Google Scholar
19.Nguyen-Legros, J, Versaux-Botter, C, Vernier, P. Dopamine receptor localization in the mammalian retina. Mol Neurobiol. 1999;19:181–204.CrossRefGoogle ScholarPubMed
20.Derouiche, A, Asan, E. The dopamine D2 receptor subfamily in rat retina: ultrastructural immunogold and in situ hybridization studies. Eur J Neurosci. 1999;11:1391–1402.CrossRefGoogle ScholarPubMed
21.Koule, P. Postnatal development of dopamine D1 receptor immunoreactivity in the rat retina. J Neurosci Res. 1999;15;56:397–404.3.0.CO;2-6>CrossRefGoogle Scholar
22.Mora-Ferrer, C, Yazulla, S, Studholme, KM, et al.Dopamine D1-receptor immunolocalization in goldfish retina. Mol Neurobiol. 1999;19:181–204.Google Scholar
23.Kramer, SG. Dopamine: a retinal neurotransmitter. 1. Retinal uptake, storage and light-stimulated release of H3-dopamine in vivo. Invest Ophthalmol. 1971;10:438–452.Google Scholar
24.Hamasaki, D, Trattler, WB, Hajek, AS. Light on inhibits and light off enhances the release of dopamine from the cat's retina [ARVO abstr]. Invest Ophthalmol. 1986;27:184.Google Scholar
25.Li, L, Dowling, JE. Effects of dopamine depletion on visual sensitivity of zebrafish. J Neurosci. 2000;20:1893–1903.CrossRefGoogle ScholarPubMed
26.Lam, RW, Beattie, CW, Buchanan, A, et al.Electroretinography in seasonal affective disorder. Psychiatry Res. 1992;43:55–63.CrossRefGoogle ScholarPubMed
27.Gerbaldo, H, Thaker, G, Tittel, PG, et al.Abnormal electroretinography in schizophrenic patients with a history of sun gazing. Neuropsychobiology. 1992;25:99–101.CrossRefGoogle ScholarPubMed
28.Smelson, DA, Roy, A. Abnormal electroretinogram in cocaine-dependent patients. Relationship to craving. Br J Psychiatry. 1996;168:507–511.Google Scholar
29.Diagnostic and Statistical Manual of Mental Disorders. 3rd ed rev. Washington, DC: American Psychiatric Association; 1987.Google Scholar
30.Spitzer, RL, Williams, JBW, Gibbon, A, et al.Structured Clinical Interview for DSM-III-R. New York, NY: Biometrics Research Department, New York State Psychiatric Institute; 1989.Google Scholar
31.Maremmani, I, Perossini, M, Castrogiovanni, P. Performance anxiety and dopaminergic system investigated by means of the electroretinogram. In: Cassano, GB, Mauri, M, eds. Anxiety States: Clinical and Neurobiological Findings. Marnate, Va: Linea Più; 1992:61–66.Google Scholar
32.Jerabek, I, Boulenger, JP, Bradwejin, J, et al.CCK4-induced panic in healthy subjects II: neurochemical correlates. Eur Neuropsychopharmacol. 1999;9:157–164.CrossRefGoogle ScholarPubMed
33.Blanchard, RJ, Kaawaloa, JN, Hebert, MA, et al.Cocaine produces panic-like flight responses in mice in the mouse defense test battery. Pharmacol Biochem Behav. 1999;64:523–528.CrossRefGoogle ScholarPubMed
34.Molina, JA, Jimenez-Jimenez, FJ, Orti-Pareja, M. Motor and mental complications in the long-term treatment of complicated Parkinson's disease with levodopa. Rev Neurol. 1999;28:982–999.Google ScholarPubMed
35.Hamilton, SP, Haghighi, F, Heiman, GA, et al.Investigation of dopamine receptor (DRD4) and dopamine transporte (DAT) polymorphisms for genetic linkage or association to panic disorder. Am J Med Genet. 2000;96:324–330.3.0.CO;2-W>CrossRefGoogle ScholarPubMed