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Elevated tau and β-amyloid in the serum of fibromyalgia patients

Published online by Cambridge University Press:  07 December 2020

Bich-Hanh Thi Nguy ,
Wen-Te Liu ,
Yu-Tai Chang ,
Chih-Peng Lin  and
Jiunn-Horng Kang Open the ORCID record for Jiunn-Horng Kang [Opens in a new window]
Bich-Hanh Thi Nguy
Affiliation:
Department of Physical Medicine and Rehabilitation, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan The International Master Program in Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
Wen-Te Liu
Affiliation:
Taipei Neuroscience Institute, Taipei Medical University, Taipei, Taiwan Sleep Center, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, Taiwan
Yu-Tai Chang
Affiliation:
Department of Physical Medicine and Rehabilitation, Taipei Medical University Hospital, Taipei, Taiwan
Chih-Peng Lin
Affiliation:
Department of Anesthesiology, National Taiwan University Hospital, Taipei, Taiwan Department of Anesthesiology, National Taiwan University College of Medicine, Taipei, Taiwan
Jiunn-Horng Kang*
Affiliation:
Department of Physical Medicine and Rehabilitation, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan Taipei Neuroscience Institute, Taipei Medical University, Taipei, Taiwan Department of Physical Medicine and Rehabilitation, Taipei Medical University Hospital, Taipei, Taiwan
*
Author for correspondence: Jiunn-Horng Kang, Email: jhk@tmu.edu.tw
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Abstract

Objective

Fibromyalgia (FM) is a chronic widespread pain syndrome. Although its mechanism remains relatively unknown, accelerated neurodegeneration in the brain has been reported in patients with FM. Sleep disturbance can increase the risk of neurocognitive disorders, which are associated with tau and beta-amyloid (Aβ) protein accumulation. We hypothesize neurodegeneration in patients with FM may be associated with sleep disturbance.

Methods

In this case-control study, we analyzed serum tau and Aβ levels and their association with symptom profiles for patients with FM, by recruiting 22 patients with FM and 22 age-matched healthy participants. The visual analog scale, Fibromyalgia Impact Questionnaire, pressure pain threshold test, Pittsburgh Sleep Quality Index (PSQI), Beck Depression Inventory-II, Beck Anxiety Inventory, and serum tau and beta-amyloid-42 (Aβ-42) levels were recorded. The Mann–Whitney test was conducted to compare questionnaire and protein level results between the groups. Pearson correlation test was conducted to investigate the correlation of questionnaire scores with tau and Aβ-42 levels in patients with FM. The significance level was set at P < .05.

Results

Serum tau and Aβ-42 levels were significantly higher in patients with FM than in controls. A positive correlation between serum tau levels and PSQI scores was observed in patients with FM (r = 0.476, P = .025). We found that only sleep disturbance in patients with FM was significantly associated with higher serum tau levels among all symptom scores.

Conclusions

We suggest sleep disturbance may play a vital role in the pathomechanism of accelerated neurodegeneration in FM.

Keywords

Fibromyalgiatau proteinbeta-amyloidsleep disturbanceneurodegeneration
Type
Original Research
Information
CNS Spectrums , Volume 27 , Issue 3 , June 2022 , pp. 339 - 346
Copyright
© The Author(s), 2020. Published by Cambridge University Press

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