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Major Psychosis and Chromosome 22: Genetics Meets Epigenetics

Published online by Cambridge University Press:  07 November 2014

Arturas Petronis ,
Violeta Popendikyte ,
Peixiang Kan  and
Tsukasa Sasaki
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Abstract

Elucidation of genetic factors in schizophrenia and bipolar disorder remains a challenging task to psychiatric researchers. As a rule, data from genetic linkage and association studies are quite controversial. In this article, we further explore the possibility that in addition to DNA sequence variation, a putative epigenetic dysregulation of brain genes plays an important role in the etiopathogenesis of major psychosis. We provide an epigenetic interpretation of unclear genetic findings specifically pertaining to chromosome 22 in schizophrenia and bipolar disorder. It is suggested that epigenetic strategies, when applied in conjunction with traditional genetic ones, may significantly expedite the uncovering of the molecular causes of major psychosis.

Type
Feature Article
Information
CNS Spectrums , Volume 7 , Issue 3 , March 2002 , pp. 209 - 214
Copyright
Copyright © Cambridge University Press 2002

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