Hostname: page-component-cd9895bd7-jn8rn Total loading time: 0 Render date: 2024-12-25T18:21:03.084Z Has data issue: false hasContentIssue false
  • English
  • Français

Neurochemical and Behavioral Effects Related to 5-HT1B/1D Receptors

Published online by Cambridge University Press:  07 November 2014

Mike Briley  and
Chantal Moret
Get access Rights & Permissions [Opens in a new window]

Abstract

The lack of selective agonists and antagonists for serotonin 5-HT1B/1D receptors has made it difficult to determine the neurochemical, behavioral, and clinical effects controlled by 5-HT1B/1D receptors. However, by combining data from various compounds with different receptor affinity profiles, it is possible to tentatively determine those effects that result from interactions at the 5-HT1B/1D receptors.

This discussion contains a review of the in vitro and in vivo neuropharmacology of the 5-HT1B/1D group of receptor subtypes, and attempts to identify their possible functions and potential implications in central nervous system disorders.

Type
Feature Article
Information
CNS Spectrums , Volume 3 , Issue 8: Serotonin Subsystems , September 1998 , pp. 22 - 29
Copyright
Copyright © Cambridge University Press 1998

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

1.Briley, M, Chopin, P, Marien, M, Moret, C. Functional neuropharmacology of compounds acting at 5-HT1B/D receptors. In: Baumgarten, HG, Göthert, M, eds. Handbook of Experimental Pharmacology: Serotonergic Neurons and 5-HT Receptors in the CNS. Heidelberg, Germany: Springer-Verlag; 1997:269–291.Google Scholar
2.Göthert, M, Schlicker, E. Regulation of 5-HT release in the CNS by presynaptic 5-HT autoreceptors and by 5-HT heteroreceptors. In: Baumgarten, HG, Göthert, M, eds. Handbook of Experimental Pharmacology: Serotonergic Neurons and 5-HT Receptors in the CNS. Heidelberg, Germany: Springer-Verlag; 1997:307–350.Google Scholar
3.Moret, C, Briley, M. 5-HT autoreceptors in the regulation of 5-HT release from guinea pig raphe nucleus and hypothalamus. Neuropharmacology. 1997;36:1713–1723.Google Scholar
4.Roberts, C, Price, GW, Gaster, L, Jones, BJ, Middlemiss, DN, Routledge, C. Importance of h5-HT1B receptor selectivity for 5-HT terminal autoreceptor activity: an in vivo microdialysis study in the freely-moving guinea-pig. Neuropharmacology. 1997;36:549–557.Google Scholar
5.Di Chiara, G. In vivo brain dialysis of neurotransmitters. Trends Pharmacol Sci. 1990;11:116–121.CrossRefGoogle ScholarPubMed
6.Macor, JE, Burkhart, CA, Heym, JH, et al.3-(1,2,5,6-Tetrahydropyrid-4-Yl)pyrrolo[3,2-b]pyrid-5-one: a potent and selective serotonin (5-HT1B) agonist and rotationally restricted phenolic analogue of 5-methoxy-3-(1,2,5,6-tetrahydropyrid-4-yl) indole. J Med Chem. 1990;33:2087–2093.CrossRefGoogle ScholarPubMed
7.Hjorth, S, Tao, R. The putative 5-HT1B receptor agonist CP-93,129 suppresses rat hippocampal 5-HT release in vivo—comparison with RU 24969. Eur J Pharmacol. 1991;209:249–252.CrossRefGoogle ScholarPubMed
8.Moret, C, Briley, M. Effects of acute and repeated administration of citalopram on extracellular levels of serotonin in rat brain. Eur J Pharmacol. 1996;295:189–197.Google Scholar
9.Bühlen, M, Brüss, M, Bönisch, H, Göthert, M. Modified ligand binding properties of the naturally occurring PhE-124-Cys variant of the human 5-HT1Dβ receptor. Naunyn Schmiedeberg's Arch Pharmacol. 1996;353:R91.Google Scholar
10.Lawrence, AJ, Marsden, CA. Terminal autoreceptor control of 5-hydroxytryptamine release as measured by in vivo microdialysis in the conscious guinea pig. J Neurochem. 1992;58:142–146.Google Scholar
11.Sleight, AJ, Cervenka, A, Peroutka, SJ. In vivo effects of sumatriptan (GR-43175) on extracellular levels of 5-HT in the guinea pig. Neuropharmacology. 1990;29:511–513.Google Scholar
12.Moret, C, Briley, M. Effects of GR 127935 on terminal 5-HT1D autoreceptors and 5-HT synthesis in guinea pig brain. Society for Neurosciences Abstracts. 1996;22:1332.Google Scholar
13.Gaster, LM, Blaney, FE, Davies, S, et al.The selective 5-HT1B receptor inverse agonist l'-methyl-5-[-[2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl]-2,3,6,7 tetrahydrospiro[furo[2,3-f]indole-3,4'-piperidine] (SB-224289) potently blocks terminal 5-HT autoreceptor function both in vitro and in vivo. J Med Chem. 1998;41:1218–1235.CrossRefGoogle Scholar
14.Briley, M, Moret, C. Neurobiological mechanisms involved in antidepressant therapies. Clin Neuropharmacol. 1993;16:387–400.Google Scholar
15.Hjorth, S, Suchowski, CS, Galloway, MP. Evidence for 5-HT autoreceptor-mediated, nerve impulse-independent, control of 5-HT synthesis in the rat brain. Synapse. 1995;19:170–176.CrossRefGoogle ScholarPubMed
16.Carlsson, A, Davis, JN, Kehr, W, Lindqvist, M, Atack, CV. Simultaneous measurement of tyrosine and tryptophan hydroxylase activities in brain in vivo using an inhibitor of the aromatic amino acid decarboxylase. Naunyn Schmiedeberg's Arch Pharmacol. 1972;275:153–168.Google Scholar
17.Moret, C, Briley, M. Which 5-HT receptors are involved in the modulation of 5-HT synthesis by the 5-HT uptake blocker, citalopram? Br J Pharmacol. 1993;108:95.Google Scholar
18.Roberts, C, Thorn, L, Price, GW, Middlemiss, DN, Jones, BJ. Effect of the selective 5-HT1D receptor antagonist, GR 127935, on in vivo 5-HT release, synthesis and turnover in the guinea pig frontal cortex. Br J Pharmacol. 1994;112:488.Google Scholar
19.Bruinvels, AT, Palacios, JM, Hoyer, D. Autoradiographic characterisation and localisation of 5-HT1D compared to 5-HT1B binding sites in the brain. Naunyn Schmiedeberg's Arch Pharmacol. 1993;347:569–582.Google Scholar
20.Green, AR, Guy, AP, Gardner, CR. The behavioural effects of RU 24969, a suggested 5-HT1 receptor agonist in rodents and the effect on the behaviour of treatments with antidepressants. Neuropharmacology. 1984;23:655–661.Google Scholar
21.Tricklebank, MD, Middlemiss, DN, Neill, J. Pharmacological analysis of the behavioural and thermoregulatory effects of the putative 5-HT1 receptor agonist, RU 24969, in the rat. Neuropharmacology. 1986;25:877–886.CrossRefGoogle ScholarPubMed
22.Chopin, P, Moret, C, Briley, M. Neuropharmacology of 5-hydroxytryptamine1B/D receptor ligands. Pharmacol Ther. 1994;62:385–405.Google Scholar
23.Grignaschi, G, Samanin, R. Role of 5-HT receptors in the effect of d-fenfluramine on feeding patterns in the rat. Eur J Pharmacol. 1992;212:287–289.Google Scholar
24.Kennett, GA, Curzon, G. Evidence that hypophagia induced by mCPP and TFMPP requires 5-HTlc and 5-HT1B receptors; hypophagia induced by RU 24969 only requires 5-HT1B receptors. Psychopharmacology. 1988;96:93–100.Google Scholar
25.Lee, MD, Simansky, KJ. CP-94,253: a selective sertonin1B (5-HT1B) agonist that promotes satiety. Psychopharmacology. 1997;131:264–270.Google Scholar
26.Kennett, GA, Dourish, CT, Curzon, G. 5-HT1B agonists induce anorexia at a post synaptic site. Eur J Pharmacol. 1987;141:429–435.CrossRefGoogle Scholar
27.Fernandez-Guasti, A, Rodriguez-Manzo, G. Further evidence showing that the inhibitory action of serotonin on rat masculine sexual behavior is mediated after the stimulation of 5-HT1B receptor. Pharmacol Biochem Behav. 1992;42:529–533.CrossRefGoogle Scholar
28.Gorzalka, BB, Mendelson, SD, Watson, NV. Serotonin receptor subtypes and sexual behavior. In: Whitaker-Azmitia, PM, Peroutka, SJ, eds. The Neuropharmacology of Serotonin. New York, NY: New York Academy of Science; 1990:435–446.Google Scholar
29.Fernandez-Guasti, A, Escalante, A. Role of presynaptic serotonergic receptors on the mechanism of action of 5-HT1A and 5-HT1B agonists on masculine sexual behaviour: physiological and pharmacological implications. J Neural Transm. 1991;85:95–107.CrossRefGoogle ScholarPubMed
30.Olivier, B, Mos, J. Rodent models of aggressive behavior and serotonergic drugs. Prog Neuropsychopharmacol Biol Psychiatry. 1992;16:847–870.CrossRefGoogle ScholarPubMed
31.Sijbesma, H, Schipper, J, De Kloet, ER, Mos, J, Van Aken, H, Olivier, B. Postsynaptic 5-HT1 receptors and offensive aggression in rats: a combined behavioural and autoradiographic study with eltoprazine. Pharmaco Biochem Behav. 1991;38:447–458.Google Scholar
32.Malick, JB, Barnett, A. The role of serotonergic pathways in isolation-induced aggression in mice. Pharmacol Biochem Behav. 1976;5:55–61.Google Scholar
33.Olivier, B, Mos, J, van der Heyden, JAM, Hartog, J. Serotonergic modulation of social interactions in isolated male mice. Psychopharmacology. 1989;97:154–156.Google Scholar
34.Briley, M, Chopin, P. Is anxiety associated with a hyperor hypo-serotonergic state? In: Palomo, T, Archer, T, eds. Strategies for Studying Brain Disorders, Depression, Anxiety and Drug Abuse Disorders. Vol 1. Donoso Cortés, Madrid, Spain: Editorial Complutence; 1994:197–209.Google Scholar
35.Sherman, AD, Allers, GL, Petty, F, Henn, FA. A neuropharmacologically relevant animal model of depression. Neuropharmacology. 1979;18:891–894.CrossRefGoogle ScholarPubMed
36.Martin, P, Beninger, RJ, Hamon, M, Puech, AJ. Antidepressant-like action of 8-OH-DPAT, a 5-HT1A agonist, in the learned helplessness paradigm: evidence for a postsynaptic mechanism. Behav Brain Res. 1990;38:135–144.CrossRefGoogle Scholar
37.Edwards, E, Harkins, K, Wright, G, Henn, FA. 5-HT1B receptors in an animal model of depression. Neuropharmacology. 1991;30:101–105.Google Scholar
38.Briley, M, Langer, SZ, Raisman, R, Sechter, D, Zarifian, E. 3H-imipramine binding sites are decreased in platelets of untreated depressed patients. Science. 1980;209:303–305.CrossRefGoogle Scholar
39.Stanley, M, Vigilio, J, Gershon, S. Tritiated imipramine binding sites are decreased in the frontal cortex of suicides. Science. 1982;216:1337–1339.CrossRefGoogle ScholarPubMed
40.Petty, F, Kramer, G, Wilson, L. Prevention of learned helplessness—in vivo correlation with cortical serotonin. Pharmacol Biochem Behav. 1992;43:361–367.Google Scholar
41.Martin, P, Puech, AJ. Is there a relationship between 5-HT1B receptors and the mechanisms of action of antidepressant drugs in the learned helplessness paradigm in rats? Eur J Pharmacol. 1991;192:193–196.CrossRefGoogle Scholar
42.McNamara, MG, Kelly, JP, Leonard, BE. Some behavioural effects of methiothepine in the olfactory bulbectomised rat model of depression. Med Sci Res. 1995;23:583–585.Google Scholar
43.Castanan, N, Ramboz, S, Saudou, F, Hen, R. In: Baumgarten, HG, Göthert, M, eds. Handbook of Experimental Pharmacology: Serotonergic Neurons and 5-HT Receptors in the CNS. Heidelberg, Germany: Springer-Verlag; 1997:351–365.Google Scholar
44.Moret, C, Briley, M. Serotonin autoreceptor subsensitivity and antidepressant activity. Eur J Pharmacol. 1990;180:351–356.Google Scholar
45.Schoups, AA, De Potter, WP. Species dependence of adaptations at the pre- and postsynaptic serotonergic receptors following long-term antidepressant drug treatment. Biochem Pharmacol. 1988;37:4451–4460.CrossRefGoogle ScholarPubMed
46.O'Connor, JJ, Kruk, ZL. Effects of 21 days treatment with fluoxetine on stimulated endogenous 5-hydroxytryptamine overflow in the rat dorsal raphe and suprachiasmatic nucleus studied using fast cyclic voltammetry in vitro. Brain Res. 1994;640:328–335.Google Scholar
47.Blier, P, Bouchard, C. Modulation of 5-HT release in the guinea pig brain following long-term administration of antidepressant drugs. Br J Pharmacol. 1994;113:485–495.Google Scholar
48.Sleight, AJ, Smith, RJ, Marsden, CA, Palfreyman, MG. The effects of chronic treatment with amitriptyline and MDL 72394 on the control of 5-HT release in vivo. Neuropharmacology. 1989;28:477–480.Google Scholar
49.Auerbach, SB, Hjorth, S. Effect of chronic administration of the selective serotonin (5-HT) uptake inhibitor citalopram on extracellular 5-HT and apparent autoreceptor sensitivity in rat forebrain in vivo. Naunyn Schmiedeberg's Arch Pharmacol. 1995;352:597–606.Google Scholar
50.Invernizzi, R, Bramante, M, Samanin, R. Extracellular concentrations of serotonin in the dorsal hippocampus after acute and chronic treatment with citalopram. Brain Res. 1995;696:62–66.Google Scholar
51.Bosker, FJ, Van Esseveldt, KE, Klompmakers, AA, Westenberg, HGM. Chronic treatment with fluvoxamine by osmotic minipumps fails to induce persistent functional changes in central 5-HT1A and 5-HT1B receptors, as measured by in vivo microdialysis in dorsal hippocampus of conscious rats. Psychopharmacology. 1995;117:358–363.Google Scholar
52.Franceschini, R, Cataldi, A, Garibaldi, A, et al.The effects of sumatriptan on pituitary secretion in man. Neuropharmacology. 1994;33:235–239.CrossRefGoogle ScholarPubMed
53.Mota, A, Bento, A, Peñalva, A, Pombo, M, Dieguez, C. Role of the serotonin receptor subtype 5-HT1D on basal and stimulated growth hormone secretion. J Clin Endocrinol Metab. 1995;80:1973–1977.Google Scholar
54.Yatham, LN, Zis, AP, Lam, RW, Tam, E, Shiah, I-S. Sumatriptan-induced growth hormone release in patients with major depression, mania and normal controls. Neuropsychopharmacology. 1997;17:258–263.Google Scholar
55.Yatham, LN, Lam, RW, Zis, AP. Growth hormone response to sumatriptan (5-HTID agonist) challenge in seasonal affective disorder: effect of light therapy. Biol Psychiatry. 1997;42:24–29.Google Scholar
56.Cleare, AJ, Murray, RM, Sherwood, RA, O'Jeane, V. Abnormal 5-HT1D receptor function in major depression: a neuropharmacological challenge study using sumatriptan. Psychol Med. 1998;28:295–300.Google Scholar
57.Zohar, J, Insel, TR, Zohar-Kadoush, RC, Hill, JL, Murphy, DL. Serotonergic responsivity in obsessive-compulsive disorder: effects of clomipramine treatment. Arch Gen Psychiatry. 1988;45:167–172.Google Scholar
58.Dolberg, OT, Sasson, Y, Cohen, R, Zohar, J. The relevance of behavioral probes in obsessive-compulsive disorder. Eur Neuropsychopharmacol. 1995;5:161–162.CrossRefGoogle Scholar
59.Charney, DS, Goodman, WK, Price, LH, Woods, SW, Rasmussen, SA, Heninger, GR. Serotonin function in obsessive-compulsive disorder. Arch Gen Psychiatry. 1988;45:177–185.CrossRefGoogle ScholarPubMed
60.Pigott, TA, Murphy, DL, Brooks, A. Pharmacological probes in OCD: support for selective 5-HT dysregulation. Presented at: First International Obsessive Compulsive Disorder Congress; March 12–13, 1993; Capri, Italy.Google Scholar
61.Vandijken, HH, Mos, J, van der Heyden, JAM, Tilders, FJH. Characterization of stress-induced long-term behavioural changes in rats—evidence in favor of anxiety. Physiol Behav. 1992;52:945–951.CrossRefGoogle Scholar
62.Vandijken, HH, van der Heyden, JAM, Mos, J, Tilders, FJH. Inescapable footshocks induce progressive and long-lasting behavioural changes in male rats. Physiol Behav. 1992;51:787–794.CrossRefGoogle Scholar