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Overlapping neurobehavioral circuits in ADHD, obesity, and binge eating: evidence from neuroimaging research

Published online by Cambridge University Press:  22 June 2015

Karen E. Seymour ,
Shauna P. Reinblatt ,
Leora Benson  and
Susan Carnell
Karen E. Seymour*
Affiliation:
Division of Child and Adolescent Psychiatry, Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
Shauna P. Reinblatt
Affiliation:
Division of Child and Adolescent Psychiatry, Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
Leora Benson
Affiliation:
Division of Child and Adolescent Psychiatry, Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
Susan Carnell
Affiliation:
Division of Child and Adolescent Psychiatry, Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
*
*Address for correspondence, Karen E. Seymour, PhD, Johns Hopkins University School of Medicine, Division of Child & Adolescent Psychiatry, Department of Psychiatry and Behavioral Sciences, 550 N. Broadway, Baltimore, MD 21205, USA.(Email: kseymou2@jhmi.edu)
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Abstract

Attention-deficit/hyperactivity disorder (ADHD) and conditions involving excessive eating (eg, obesity, binge/loss of control eating) are increasingly prevalent within pediatric populations, and correlational and some longitudinal studies have suggested inter-relationships between these disorders. In addition, a number of common neural correlates are emerging across conditions, eg, functional abnormalities within circuits subserving reward processing and executive functioning. To explore this potential cross-condition overlap in neurobehavioral underpinnings, we selectively review relevant functional neuroimaging literature, specifically focusing on studies probing (i) reward processing, (ii) response inhibition, and (iii) emotional processing and regulation, and we outline 3 specific shared neurobehavioral circuits. Based on our review, we also identify gaps within the literature that would benefit from further research.

Keywords

Attention-deficit/hyperactivity disordercomorbidityfMRIobesityoverweight
Type
Review Articles
Information
CNS Spectrums , Volume 20 , Special Issue 4: Pediatric Neuroimaging , August 2015 , pp. 401 - 411
Copyright
© Cambridge University Press 2015 

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