Hostname: page-component-78c5997874-g7gxr Total loading time: 0 Render date: 2024-11-15T06:53:54.615Z Has data issue: false hasContentIssue false
  • English
  • Français

Sleep Disorders Associated with Parkinson's Disease: Role of Dopamine, Epidemiology, and Clinical Scales of Assessment

Published online by Cambridge University Press:  07 November 2014

Shyamal H. Mehta ,
John C. Morgan  and
Kapil D. Sethi
Get access Rights & Permissions [Opens in a new window]

Abstract

Sleep dysfunction is common among patients with Parkinson's disease and occurs in approximately two thirds of patients. The problems range from nocturnal issues such as difficulty with sleep initiation, sleep fragmentation, disturbance of circadian rhythm, and rapid eye movement sleep behavior disorder, to daytime problems such as excessive daytime sleepiness. Frequent nighttime awakening and sleep disruption are the most common sleep problems in Parkinson's disease. Dopamine plays an important role in maintaining wakefulness. To improve sleep in Parkinson's disease, it is important to achieve the critical balance of adequate dopaminergic therapy and control of symptoms. Increased dopaminergic agents can cause dyskinesias and painful dystonia, and undertreatment can cause nighttime akinesia, rigidity, and worse quality of sleep. Other nondopaminergic drugs commonly used in Parkinson's disease can also affect sleep. In patients with advanced Parkinson's disease, deep brain stimulation of the subthalamic nucleus has a favorable impact on sleep quality and sleep architecture.

Type
Supplement
Information
CNS Spectrums , Volume 13 , Issue S4: Neuropsychiatric Aspects of Parkinson's Disease: Focus on Insomnia, Daytime Sleepiness, and Psychosis , March 2008 , pp. 6 - 11
Copyright
Copyright © Cambridge University Press 2008

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

1.Shulman, LM, Taback, RL, Rabinstein, AA, Weiner, WJ. Non-recognition of depression and other non-motor symptoms in Parkinson's disease. Parkinsonism Relat Disord. 2002;8(3):193–197.CrossRefGoogle ScholarPubMed
2.Trenkwalder, C. Sleep dysfunction in Parkinson's disease. Clinical Neuroscience. 1998;5(2):107–114.Google Scholar
3.Monti, JM, Monti, D. The involvement of dopamine in the modulation of sleep and waking. Sleep Med Rev. 2007;11(2):113–133.Google Scholar
4.Wisor, JPNishino, S, Sora, I, Uhl, GH, Mignot, E, Edgar, DM. Dopaminergic role in stimulant-induced wakefulness. J Neurosci. 2001;21(15):1787–1794.Google Scholar
5.Monaca, C, Laloux, C, Jacquesson, JM, et al.Vigilance states in a parkinsonian model, the MPTP mouse. Eur J Neurosci. 2004;20(9):2474–2478.Google Scholar
6.Decker, M, Keating, G, Freeman, A, et al.Parkinsonian-like sleep-wake architecture in rats with bilateral striatal 6-OHDA lesions. Soc Neurosci Abstr. 2000;26:1514.Google Scholar
7.Trampus, M, Ferri, N, Monopoli, A, et al.The dopamine D1 receptor agonists, A68930 and SKF 38393, induce arousal and suppress REM sleep in rats. Eur J Pharmacol. 1993;235:83–87.Google Scholar
8.Monti, JM, Hawkins, M, Jantos, H, et al.Biphasic effects of dopamine D-2 receptor agonists on sleep and wakefulness in the rat. Psychopharmacology (Berl). 1988;95(3):395–400.Google Scholar
9.Lagos, P, Scorza, C, Monti, JM, et al.Effects of the D3 preferring dopamine agonist pramipexole on sleep, waking, locomotor activity and striatal dopamine release in rats. Eur Neuropsychopharmacol. 1998;8(2):113–120.Google Scholar
10.Paus, S, Brecht, HM, Köster, J, Seeger, G, Klockgether, T, Wüllner, U. Sleep attacks, day time sleepiness and dopamine agonists in Parkinson's disease. Mov Disord. 2003;18(6):659–667.Google Scholar
11.Clemens, S, Rye, DB, Hochman, S. Restless legs syndrome: revisiting the dopamine hypothesis from the spinal cord perspective. Neurology. 2006;67:125–130.CrossRefGoogle ScholarPubMed
12.Hue, GE, Decker, MJ, Solomon, IG, Rye, DB. Increased wakefulness and hyper-responsivity to novel environments in mice lacking functional dopamine D3 receptors. Soc Neurosci. 2003;616:16.Google Scholar
13.Cavas, M, Navarro, JF. Effects of selective dopamine D4 receptor antagonist, L-741,741, on sleep and wakefulness in the rat. Prog Neuropsychopharmacol Biol Psychiatry. 2006;30(4):668–678.Google Scholar
14.Sealfon, SC, Olanow, CW. Dopamine receptors: from structure to behavior. Trends Neurosci. 2000;23(Suppl 10):34–40.Google Scholar
15.Happe, S, Pirker, W, Klösch, G, Sauter, C, Zeitlhofer, J. Periodic leg movements in patients with Parkinson's disease are associated with reduced striatal dopamine transporter binding. J Neurol. 2003;250(1):83–86.Google Scholar
16.Hilker, R, Razal, N, Ghaemi, M, et al.[18F]fluorodopa uptake in the upper brainstem measured with positron emission tomography correlates with decreased REM sleep duration in early Parkinson's disease. Clin Neurol Neurosurg. 2003;105(4):262–269.Google Scholar
17.Elsensehr, I, Linke, R, Tatsch, K, et al.Increased muscle activity during rapid eye movement sleep correlates with decrease of striatal presynaptic dopamine transporters. IPT and IBZM SPECT imaging in subclinical and clinically manifest idiopathic REM sleep behavior disorder, Parkinson's disease, and controls. Sleep. 2003;26(5):507–512.Google Scholar
18.Happe, S, Anderer, P, Pirker, W, et al.Sleep microstructure and neurodegeneration as measured by [I123] -CIT SPECT in treated patients with Parkinson's disease. J Neurol. 2004;251(12):1465–1471.Google Scholar
19.Porter, B, Macfarlane, R and Walker, P. The frequency and nature of sleep disorders in a community-based population of patients with Parkinson's disease. Eur J Neurol. 2008;15(1):50–54.CrossRefGoogle Scholar
20.van Hilten, B, Hoff, JI, Middelkoop, HA, et al.Sleep disruption In Parkinson's disease. Assessment by continuous activity monitoring. Arch Neurol. 1994;51(9):922–928.Google Scholar
21.Lavie, P, Wajsbort, J, Youdim, MB. Deprenyl does not cause Insomnia In parkinsonian patients. Commun Psychopharmacol. 1980;4(4):303–307.Google Scholar
22.Arnulf, I, Konofal, E, Merlno-Andreu, M, et al, Parkinson's disease and sleepiness: an integral part of PD. Neurology. 2002;58(7):1019–1024.Google Scholar
23.Maria, B, Sophia, S, Michalis, M, et al.Sleep breathing disorders in patients with idiopathic Parkinson's disease. Respir Med. 2003;97(10):1151–1157.Google Scholar
24.Garcia-Borreguero, D, Larrosa, O, Bravo, M. Parkinson's disease and sleep. Sleep Med Rev. 2003;7(2):115–129.Google Scholar
25.Apps, MC, Sheaff, PC, Ingram, DA, Kennard, C, Empey, DW. Respiration and sleep In Parkinson's disease. J Neurol Neurosurg Psychiatry. 1985;48(12):1240–1245.Google Scholar
26.Pappert, EJ, Goetz, CG, Niederman, FG, Raman, R, Leurgans, S. Hallucinations, sleep fragmentation, and altered dream phenomena In Parkinson's disease. Mov Disord. 1999;14(1):117–121.Google Scholar
27.Meral, H, Aydemir, T, Ozer, F, et al.Relationship between visual hallucinations and REM sleep behavior disorder in patients with Parkinson's disease. Clin Neurol Neurosurg. 2007;109(10):862–867.Google Scholar
28.Thannickal, TC, Lai, YY, Siegel, JM. Hypocretin (orexin) cell loss In Parkinson's disease. Brain. 2007;130(Pt 6):1586–1595.CrossRefGoogle ScholarPubMed
29.Comella, CL. Sleep disturbances and excessive daytime sleepiness in Parkinson's disease: an overview. J Neural Transm Suppl. 2006;70:349–355.Google Scholar
30.Tandberg, E, Larsen, JP, Karisen, K. Excessive daytime sleepiness and sleep benefit In Parkinson's disease: a community-based study. Mov Disord. 1999;14(6):922–927.Google Scholar
31.Freedom, T. Sleep and Parkinson's disease. Dis Mon. 2007;53(5):275–290.CrossRefGoogle ScholarPubMed
32.Ghorayeb, I, Loundou, A, Auquier, P, et al.A nationwide survey of excessive daytime sleepiness in Parkinson's disease in France. Mov Disord. 2007;22(11):1567–1572.Google Scholar
33.Brodsky, MA, Godbold, J, Roth, T, Olanow, CW. Sleepiness in Parkinson's disease: a controlled study. Mov Disord. 2003;18(6):668–672.Google Scholar
34.Razmy, A, Lang, AE, Shapiro, CM. Predictors of impaired daytime sleep and wakefulness In patients with Parkinson disease treated with older (ergot) vs newer (nonergot) dopamine agonists. Arch Neurol.2004;61(1):97–102.CrossRefGoogle ScholarPubMed
35.Gjerstad, MD, Alves, G, Wentzel-Larsen, T, Aarsland, D, Larsen, JP. Excessive daytime sleepiness In Parkinson disease: Is It the drugs or the disease? Neurology. 2006;67(5):853–858.Google Scholar
36.Stevens, S, Cormella, CL, Stepanski, EJ. Daytime sleepiness and alertness in patients with Parkinson disease. Sleep. 2004;27(5):967–972.Google Scholar
37.Rye, DB, Bllwise, DL, Dinenia, B, et al.FAST TRACK: daytime sleepiness in Parkinson's disease. J Sleep Res. 2000;9(1):63–69.Google Scholar
38.Johns, MW. A new method for measuring daytime sleepiness: the Epworth Sleepiness Scale. Sleep 1991;14(6):540–545.Google Scholar
39.Hagell, P, Broman, JE. Measurement properties and hierarchical item structure of the Epworth Sleepiness Scale in Parkinson's disease. J Sleep Res. 2007;16(1):102–109.Google Scholar
40.Chaudhuri, KR, Pal, S, DiMarco, A, et al.The Parkinson's disease sleep scale: a new Instrument for assessing sleep and nocturnal disability In Parkinson's disease. J Neurol Neurosurg Psychiatry. 2002;73(6):629–635.Google Scholar
41.Dhawan, V, Dhoat, S, Williams, AJ, et al.The range and nature of sleep dysfunction in untreated Parkinson's disease (PD). A comparative controlled clinical study using the Parkinson's disease sleep scale and selective polysomnography. J Neurol Sci. 2006;248(1–2):158–162.CrossRefGoogle ScholarPubMed
42.Marinus, J, Visser, M, van Hilten, JJ, Lammers, GJ, Stiggelbout, AM, Assessment of sleep and sleepiness in Parkinson disease. Sleep. 2003;26(8):1049–1054.Google Scholar
43.Buysse, DJ, Reynolds, CF3rd, Monk, TH, Berman, SR, Kupfer, DJ. The Pittsburgh Sleep Quality Index: a new Instrument for psychiatric practice and research. Psychiatry Res. 1989;28(2):193–213.Google Scholar
44.Akerstedt, T, Gillberg, M. Subjective and objective sleepiness in the active Individual. Int J Neurosci. 1990;52(1–2):29–37.CrossRefGoogle ScholarPubMed
45.Hoddes, E, Zarcone, V, Smythe, H, Phillips, R, Dement, WC. Quantificatication of sleepiness: a new approach. Psychophysiology. 1973;10(4):431–436.Google Scholar
46.Askenasy, JJ, Yahr, MD. Suppression of REM rebound by pergolide. J Neurol Transm. 1984;59(2):151–159.Google Scholar
47.Vardi, J, Glaubman, H, Rabey, J, Streifler, M. EEG sleep patterns In Parkinsonian patients treated with bromocryptine and L-dopa: a comparative study. J Neural Transm. 1979;45(4):307–316.Google Scholar
48.Comella, CL, Morrissey, M, Janko, K. Nocturnal activity with nighttime pergolide in Parkinson disease: a controlled study using actigraphy. Neurology. 2005;64(8):1450–1451.Google Scholar
49.Calabrese, JR, Keck, PR Jr, Macfadden, W, et al.A randomized, double-blind, placebo-controlled trial of quetiapine in me treatment of bipolar I or II depression. Am J Psychiatry. 2005;162(7):1351–1360.Google Scholar
50.Poewe, W. Depression In Parkinson's disease. J Neurol. 2007;254(suppl 5):49–55.Google Scholar
51.Lemke, MR, Brecht, HM, Koester, J, Kraus, PH, Reichmann, H. Anhedonia, depression, and motor functioning in Parkinson's disease during treatment with pramipexole. J Neuropsychiatry Clin Neurosci. 2005;17:214–220.Google Scholar
52.Mayers, AG, Baldwin, DS. Antidepressants and their effect on sleep. Hum Psychopharmacol. 2005;20(8):533–559.Google Scholar
53.Lyons, KE, Pahwa, R. Effects of bilateral subthalamic nucleus stimulation on sleep, daytime sleepiness, and early morning dystonia in patients with Parkinson disease. J Neurosurg. 2006;104(4):502–505.Google Scholar
54.Antonini, A, Landi, A, Mariani, C, DeNotaris, R, Pezzoli, G. Deep brain stimulation and its effect on sleep In Parkinson's disease. Sleep Med. 2004;5:211–214.Google Scholar
55.Cicolin, A, Lopiano, L, Zibetti, M, et al.Effects of deep brain stimulation of the subthalamic nucleus on sleep architecture in parkinsonian patients. Sleep Med. 2004;5:207–210.Google Scholar