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Special Considerations in Diagnosing and Treating Attention-Deficit/Hyperactivity Disorder

Published online by Cambridge University Press:  07 November 2014

Sharon B. Wigal
Affiliation:
Dr. Sharon Wigal is clinical professor of pediatrics at the University of California, Irvine
Timothy L. Wigal
Affiliation:
Dr. Timothy Wigal is associate clinical professor of pediatrics at the University of California, Irvine.

Abstract

Attention-deficit/hyperactivity disorder (ADHD) is a prevalent chronic condition that affects people of all ages, including young children, school-aged children, adolescents, and adults. Symptoms can be noted as early as preschool age, tend to progress into functional impairment and behavioral problems in later childhood, and typically persist into adulthood. Contrary to previous belief, the disorder does not resolve with puberty for the majority of children; rather, the symptoms are manifested differently throughout the lifecycle. Presentation in adults is heavily biased toward inattentive symptoms, which are less likely to draw notice than hyperactive or impulsive symptoms and may contribute to the underrecognition of ADHD in this patient population. Diagnosis is particularly difficult due in large part to the pronounced comorbidity of psychiatric disorders in this patient population. Identification may be even more difficult in adults than children as the diagnostic criteria are not as clear, adults have difficulty remembering symptoms prior to 7 years of age, and there is a high prevalence of comorbid psychiatric disorders in adults. Early identification and treatment of symptoms of ADHD in preschool-age children is essential to effective long-term management of the disorder. Both medication and behavioral treatments appear to alleviate the symptoms of ADHD, and evidence suggests that discontinuation of treatment leads to the reemergence of the condition. Efforts are currently continuing toward understanding the genetic underpinnings of ADHD.

This expert review supplement will address the prevalence, comorbidity, treatment issues, and special considerations surrounding ADHD management throughout each stage of the lifecycle beginning with ADHD in preschool-aged children, continuing with school-aged children and adolescents, and ending with adulthood.

Type
Research Article
Copyright
Copyright © Cambridge University Press 2007

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References

1.Lavigne, JV, Gibbons, RD, Christoffel, KK, et al.Prevalence rates and correlates of psychiatric disorders among preschool children. J Am Acad Child Adolesc. 1996;32:204214.CrossRefGoogle Scholar
2.Campbell, SB. Parent-referred problem three-year-olds: developmental changes in symptoms. J Child Psychol Psychiatry. 1987;28:835845.CrossRefGoogle ScholarPubMed
3.DuPaul, GJ, McGoey, KE, Eckert, TL, VanBrakle, J. Preschool children with attention-deficit/hyperactivity disorder: impairments in behavioral, social, and school functioning. J Am Acad Child Adolesc. 2001;40:508515.CrossRefGoogle ScholarPubMed
4.Lahey, BB, Pelham, WE, Stein, MA, et al.Validity of DSM-IV attention-deficit/hyperactivity disorder for younger children. J Am Acad Child Adolesc. 1998;37:695702.CrossRefGoogle ScholarPubMed
5.LaHoste, GJ, Swanson, JM, Wigal, SB, et al.Dopamine D4 receptor gene polymorphism is associated with attention deficit hyperactivity disorder. Mol Psychiatry. 1996;1:121124.Google ScholarPubMed
6.Lahey, BB, Pelham, WE, Loney, J, et al.Three-year predictive validity of DSM-IV attention deficit hyperactivity disorder in children diagnosed at 4Y6 years of age. Am J Psychiatry. 2004;161:20142020.CrossRefGoogle Scholar
7.Pierce, EW, Ewing, LJ, Campbell, SB. Diagnostic status and symptomatic behavior of hard-to-manage preschool children in middle childhood and early adolescence. J Clin Child Psychol. 1999;28:4457.CrossRefGoogle ScholarPubMed
8.Wilens, TE, Biederman, J, Brown, S, Monuteaux, M, Prince, J, Spencer, TJ. Patterns of psychopathology and dysfunction in clinically referred preschoolers. J Dev Behav Pediatr. 2002;23:S31S36.CrossRefGoogle ScholarPubMed
9.Medco Health Solutions. 2004 Drug Trend Report. Available at: www.medcohealth.com. Accessed May 17, 2004.Google Scholar
10.Zito, JM, Safer, DJ, dosReis, S, Gardner, JF, Boles, M, Lynch, F. Trends in the prescribing of psychotropic medications to preschoolers. JAMA. 2000;283:10251030.CrossRefGoogle ScholarPubMed
11.Kollins, S, Greenhill, L, Swanson, J, et al.Rationale, design, and methods of the Preschool ADHD Treatment Study (PATS). J Am Acad Child Adolesc Psychiatry. 2006;45(11):12751283.CrossRefGoogle ScholarPubMed
12.Diagnostic and Statistical Manual of Mental Disorders. 4th ed. Washington, DC: American Psychiatric Association; 1994.Google Scholar
13.Manidiaki, K, Sonuga-Barke, E, Kakouros, E, Karaba, R. Parental beliefs about the nature of ADHD behaviours and their relationship to referral intentions in preschool children. Child Health Care Dev. 2007;33:188.CrossRefGoogle Scholar
14. NIMH ADHD site. Available at: www.nimh.nih.gov/publicat/adhd.cfm#diag. Accessed May 13, 2007.Google Scholar
15.Consensus Development Panel. Defined Diets and Childhood Hyperactivity. National Institutes of Health Consensus Development Conference Summary. 1982; Vol 4, No 3.Google Scholar
16.Biederman, J, Faraone, SV, Keenan, K, Knee, D, Tsuang, MF. Family-genetic and psychosocial risk factors in DSM-III attention deficit disorder. J Am Acad Child Adolesc Psychiatry. 1990;29:526533.CrossRefGoogle ScholarPubMed
17.Faraone, SV, Biederman, J. Neurobiology of attention-deficit hyperactivity disorder. Biol Psychiatry. 1998;44;951958.CrossRefGoogle ScholarPubMed
18.Faraone, SV, Perlis, RH, Doyle, AE, et al.Molecular genetics of attention-deficit/hyperactivity disorder. Biol Psychiatry. 2005;57:13131323.CrossRefGoogle ScholarPubMed
19.Kennedy, JL. Dopamine D4 receptor gene polymorphism is associated with attention deficit hyperactivity disorder. Mol Psychiatry. 2004;1:121124.Google Scholar
20.Lowe, N, Kirley, A, Hawi, Z, et al.Joint analysis of the DRD5 marker concludes association with attention-deficit/hyperactivity attention-deficit/hyperactivity disorder confined to the predominantly inattentive and combined subtypes. Am J Hum Genet. 2004;74:348356.CrossRefGoogle Scholar
21.McGough, JJ. Attention-deficit/hyperactivity disorder pharmacogenomics. Biol Psychiatry. 2005;57:13671373.CrossRefGoogle ScholarPubMed
22.El-Faddagh, M, Laucht, M, Maras, A, et al.Association of dopamine D4 receptor (DRD4) gene with attention-deficit/hyperactivity disorder (ADHD) in a high-risk community sample: a longitudinal study from birth to 11 years of age. J Neur Trans. 2004;111: 883889.CrossRefGoogle Scholar
23.Swanson, JM, Kraemer, HC, Hinshaw, SP, et al.Clinical relevance of the primary findings of the MTA: success rates based on severity of ADHD and ODD symptoms at the end of treatment. J Am Acad Child Adolesc. 2001:40;168179.CrossRefGoogle ScholarPubMed
24.Thapar, A, Langley, K, Fowler, T, et al.Catechol o-methyltransferase gene variant and birth weight predict early-onset antisocial behavior in children with attention-deficit/hyperactivity disorder. Arch Gen Psychiatry. 2005;62:12751278.CrossRefGoogle ScholarPubMed
25.Thapar, A, Langley, K, O'Donovan, M, et al.Refining the attention deficit hyperactivity disorder phenotype for molecular genetic studies. Mol Psychiatry. 2006;11:714720.CrossRefGoogle ScholarPubMed
26.MTA Cooperative Group. A 14-month randomized clinical trial of treatment strategies for attention deficit hyperactivity disorder. Arch Gen Psychiatry. 1999;56:10731086.CrossRefGoogle Scholar
27.Wender, PH. ADHD: Attention-Deficit Hyperactivity Disorder in Children and Adults. Oxford University Press. 2002:9.Google Scholar
28.Geller, B, Williams, M, Zimerman, B, Frazier, J, Beringer, L, Warner, KL. Prepubertal and early adolescent bipolarity differentiate from ADHD by manic symptoms, grandiose delusions, ultra-rapid or ultradian cycling. J Affect Disord. 1998;51:8191.CrossRefGoogle ScholarPubMed
29.Barkley, RA, The effects of methylphenidate on the interactions of preschool ADHD children with their mothers. J Am Acad Child Adolesc. 1998;27:336341.CrossRefGoogle Scholar
30.Cohen, NJ. Evaluation of the relative effectiveness of methylphenidate and cognitive behavior modification in the treatment of kindergarten-aged hyperactive children. J Abnormal Child Psychol. 1981;9:4354.CrossRefGoogle ScholarPubMed
31.Handen, BL, Feldman, HM, Lurier, A, Murray, PJ. Efficacy of methylphenidate among preschool children with developmental disabilities and ADHD. J Am Acad Child Adolesc. 1999;38:805812.CrossRefGoogle ScholarPubMed
32.Swanson, J, Greenhill, L, Wigal, T, et al.Stimulant-related reductions of growth rates in the PATS. J Am Acad Child Adolesc. 2006;45:13041313.CrossRefGoogle ScholarPubMed
33.Wigal, S, Gupta, S, Greenhill, L, et al.Pharmacokinetics of methylphenidate in preschoolers with attention-deficit/hyperactivity disorder. J Child Adolesc Psychopharmacol. In press.Google Scholar
34.Greenhill, L, Kollins, S, Abikoff, H, et al.Rationale, design, and methods of the preschool ADHD treatment study (PATS). J Am Acad Child Adolesc. 2006;45:11.Google Scholar
35.Sonuga-Barke, EJ, Daley, D, Thompson, M, Laver-Bradbury, C, Weeks, A. Parent-based therapies for preschool attention-deficit/hyperactivity disorder: a randomized, controlled trial with a community sample. J Am Acad Child Adolesc. 2001;40:402408.CrossRefGoogle ScholarPubMed
36.Olfson, M. Diagnosing mental disorders in office-based pediatric practice. J Dev Behav Pediatr. 1992;13:363365.Google ScholarPubMed
37.Frazier, T, Youngstrom, E, Glutting, J, Watkins, M. ADHD and achievement: meta-analysis of the child, adolescent, and adult literature and a concomitant study with college students. Journal of Learning Disabilities. 2007;40:4965.CrossRefGoogle Scholar
38.Bagwell, C, Molina, B, Pelham, W, Hoza, B. Attention deficit hyperactivity disorder and problems in peer relations: predictions from childhood to adolescence. J Am Acad Child Adolesc Psychiatry. 2001;40:12851292.CrossRefGoogle ScholarPubMed
39.Pelham, W, Foster, M, Robb, J. The Economic impact of attention-deficit/hyperactivity disorder in children and adolescents. Ambulatory Pediatrics. 2007;7:121131.CrossRefGoogle ScholarPubMed
40.Biederman, J, Farone, S, Milberger, S, et al.A prospective 4-year follow-up study of attention-deficit/hyperactivity and related disorders. Arch Gen Psychiatry. 1996;53:437446.CrossRefGoogle ScholarPubMed
41.Ingram, S, Hechtman, L, Morgenstern, G. Outcome issues in ADHD: adolescent and adult long-term outcome. Ment Retard Dev Disabil Res Rev. 1999;5:243250.3.0.CO;2-D>CrossRefGoogle Scholar
42.Biederman, J, Newcorn, JH, Sprich, S. Comorbidity of attention-deficit hyperactivity disorder with conduct, depressive, anxiety and other disorders. Am J Psychiatry. 1991;148:251256.Google ScholarPubMed
43.Abikoff, H, Courtney, M, Pelham, WE, Koplewicz, HS. Teachers' ratings of disruptive behaviors: the influence of halo effects. J Abnorm Child Psychol. 1993;21:519533.CrossRefGoogle ScholarPubMed
44.Schachar, R, Sandber, S, Rutter, M. Agreement between teachers' ratings and observations of hyperactivity, inattentiveness and defiance. J Abnorm Child Psychol. 1986;14:331345.CrossRefGoogle ScholarPubMed
45.Pliszka, SR. Effect of anxiety on cognition, behavior and stimulant response in ADHD. J Am Acad Child Adolesc Psychiatry. 1989;28:882887.CrossRefGoogle ScholarPubMed
46.Rappley, MD, Gardiner, JC, Jetton, JR, Houang, RT. The use of methylphenidate in Michigan. Arch Pediatr Adolesc Med. 1995;149:675679.CrossRefGoogle ScholarPubMed
47.Rowland, AS, Lesesne, CA, Abramowitz, AJ. The epidemiology of attention-deficit/hyperactivity disorder (ADHD): a public health view. Ment Ret Dev Dis Res Rev. 2002;8:162170.Google ScholarPubMed
48.NIMH. Attention Deficit Hyperactivity Disorder. 2006. Available at: http://www.nimh.nih.gov/publicat/adhd.cfm#intro. Accessed April 19, 2007.Google Scholar
49.Mental health in the United States: prevalence of diagnosis and medication treatment for attention-deficit/hyperactivity disorder--United States, 2003.MMWR Morb Mortal Wkly Rep. 2005;54(34);842847.Google Scholar
50.Wilens, T. Alcohol and other drug use and attention deficit hyperactivity disorder. Alcohol Health Res World. 1998;22:127130.Google ScholarPubMed
51.Gittelman, R, Mannuzza, S, Shenker, R, Bonagura, N. Hyperactive boys almost group up: I. Psychiatric status. Arch Gen Psychiatry. 1985;42:937947.CrossRefGoogle ScholarPubMed
52.Hechtman, L, Weiss, G. Controlled prospective fifteen year follow-up of hyperactives as adults: non-medical drug and alcohol use and anti-social behaviour. Can J Psychiatry. 1986;31:557567.CrossRefGoogle ScholarPubMed
53.Barkley, R. Driving Impairments in teens and adults with attention-deficit/hyperactivity disorder. Psychiatr Clin North Am. 2004;27:233260.CrossRefGoogle ScholarPubMed
54.Johnston, C, Mash, E. Families of children with attention deficit hyperactivity disorder: review and recommendations for future research. Clin Child Family Psychol. 2001;4:183207.CrossRefGoogle ScholarPubMed
55.Biederman, J, Wilens, T, Mick, E, et al.Does attention-deficit hyperactivity disorder impact the developmental course of drug and alcohol abuse and dependence? Biol Psychiatry. 1998;36:3743.Google Scholar
56.Silver, LB. The relationship between learning disabilities, hperactivty, distractibility, and behavioral problems. J Am Acad Child Psychiatry. 1981;20:385397.CrossRefGoogle ScholarPubMed
57.Biederman, J, Faraone, SV, Mick, E, et al.Attention deficit hyperactivity disorder and juvenile mania: an overlooked comorbidity? J Am Acad Child Adolesc Psychiatry. 1996;35:9971008.CrossRefGoogle ScholarPubMed
58.Spencer, J, Biederman, J, Mick, E. Attention-deficit/hyperactivity disorder: diagnosis, lifespan, comorbidities, and neurobiology. Ambulatory Pediatrics. 2007;7:7381.CrossRefGoogle ScholarPubMed
59.Goldman, S, Genel, M, Bezman, R, Slanetz, P. Diagnosis and treatment of attention-deficit/hyperactivity disorder in children and adolescents. JAMA. 1998;279:11001107.CrossRefGoogle ScholarPubMed
60.Biederman, J, Newcorn, J, Sprich, S. Comorbidity of attention deficit hyperactivity disorder with conduct, depressive, anxiety, and other disorders. Am J Psychiatry. 1991;148:564577.Google ScholarPubMed
61.Biederman, J, Faraone, SV, Milberger, S, et al.Is childhood oppositional defiant disorder a precursor to adolescent conduct disorder? Findings from a 4-year follow-up study of children with ADHD. J Am Acad Child Adolesc Psychiatry. 1996;35:11931204.CrossRefGoogle ScholarPubMed
62.Klorman, R, Brumaghim, JT, Salzman, LF, et al.Effects of methylphenidate on attention-deficit hyperactivity disorder with and without aggressive/noncompliant features. J Abnorm Psychol. 1988;97:413422.CrossRefGoogle ScholarPubMed
63.Biederman, J, Faraone, SV, Keenan, K, et al.Further evidence for family-genetic risk factors in attention deficit hyperactivity disorder. Patterns of comorbidity in probands and relatives in psychiatrically and pediatrically referred samples. Arch Gen Psychiatry. 1992;49:728738.CrossRefGoogle ScholarPubMed
64.Brent, DA, Perper, JA, Goldstein, CE, et al.Risk factors for adolescent suicide: a comparison of adolescent suicide victims with suicidal inpatients. Arch Gen Psychiatry. 1988;45:581588.CrossRefGoogle ScholarPubMed
65.Biederman, J, Faraone, S, Keenan, K, et al.Family genetic and psychosocial risk factors in attention deficit disorder. Biol Psychiatry. 1989;25:145A.CrossRefGoogle Scholar
66.Morgan, A, Hynd, G, Riccio, C, Hall, J. Validity of DSM-IV ADHD predominately inattentive and combined types: relationship to previous DSM diagnoses/subtype differences. J Am Acad Child Adolsec Psychiatry. 1996;35:325333.CrossRefGoogle Scholar
67.Paternite, C, Loney, J, Roberts, M. External validation of oppositional disorder and attention deficit disorder with hyperactivity. J Abnorm Child Psychol. 1995;23:453471.CrossRefGoogle ScholarPubMed
68.Wolraich, M, Hannah, J, Pinnock, T, et al.Comparison of diagnostic criteria for attention-deficit hyperacitivty disorder in a country-wide sample. J Am Acad Child Adolesc Psychiatry. 1996;35:319324.CrossRefGoogle Scholar
69.Sleator, E, Ullman, R. Can the physician diagnose hyperactivity in the office? Pediatrics. 1981;67:1317.CrossRefGoogle ScholarPubMed
70.Mitsis, E, McKay, K, Schulz, K, et al.Parent-teacher concordance for DSM-IV attention-deficit/hyperactivity disorder in a clinic-referred sample. Child Adolesc Psychiatry. 2000;39:308313.CrossRefGoogle Scholar
71.Molina, B, Pelham, W, Blumenthal, J, Galiszewski, E. Agreement among teachers' behavior ratings of adolescents with a childhood history of attention-deficit/hyperactivity disorder. J Clin Child Psychol. 1998;27:330339.CrossRefGoogle ScholarPubMed
72.Kramer, T, Phillips, S, hargis, M, et al.Disagreement between parent and adolescent reports of functional impairment. J Child Psychol Psychiatry. 2004;45:248259.CrossRefGoogle ScholarPubMed
73.Kiddie-Sads-Present and Lifetime Version (K-SADS-PL). Available at: http://www.wpic.pitt.edu/ksads/default.htm. Accessed April 19, 2007.Google Scholar
74.Achenbach, T, Edelbrock, L. Manual for the Child Behavior Checklist 4-18 and 1991 Profile. Burlington, VT: University of Vermont; 1991.Google Scholar
75.Reynolds, C, Kamphouse, R. BASC: Behavior Assessment System for Children Manual. Circle Pines, MN: American guidance Service; 1992.Google Scholar
76.Brown, TE. Brown ADD Scales for Children and Adolescents. San Antonio, TX: Psychological Corp; 2001.Google Scholar
77.Swanson, J, Nolan, R, Pelham, W. Swanson, Nolan and Pelham Rating Scale (SNAP). Pittsburgh, PA, Department of Psychiatry, Western Psychiatric Institute and Clinic; 1998.Google Scholar
78.Shaffer, D, Fisher, P, Dulcan, M, et al.The second version of the NIMH Diagnostic Interview Schedule for Children (DISC-2). J Am Acad Child Adolesc Psychiatry. 1996;35:865877.CrossRefGoogle Scholar
79.Quinn, P, Wigal, S. Perceptions of girls and ADHD: results from a national survey. Med Gen Med. 2004;6:2.Google ScholarPubMed
80.Sharp, WS, Walter, J, Marsh, W, Ritchie, G, Hamburger, S, Castellanos, F. ADHD in girls: clinical comparability of a research sample. J Am Acad Child Adolesc Psychiatry. 1999;38:4047.CrossRefGoogle ScholarPubMed
81.Biederman, J, Faraone, S, Milberger, S, et al.Clinical correlates of ADHD in females: findings from a large group of girls ascertained from pediatric and psychiatric referral sources. J Am Acad Child Adolesc Psychiatry. 1999;38:966975.CrossRefGoogle ScholarPubMed
82.Carlson, C, Tamm, L, Gaub, M. Gender differences in children with ADHD, ODD and co-occurring ADHD/ODD identified in a school population. J Am Acad Child Adolesc Psychiatry. 1997;36:17061714.CrossRefGoogle Scholar
83.Gaub, M, Carlson, C. Gender differences in ADHD: a meta-analysis and critical review. J Am Acad Child Adolesc Psychiatry. 1997;36:10361045.CrossRefGoogle ScholarPubMed
84.Wigal, S, McGough, J, McCracken, J, et al.A laboratory school comparison of mixed amphetamine salts extended release (Adderall XR) and atomoxetine (Strattera) in school-aged children with attention deficit/hyperactivity disorder. J Atten Disord. 2005;9:275:289.CrossRefGoogle ScholarPubMed
85.Arnold, L. Alternative treatments for adults with attention-deficit hyperactivity disorder (ADHD). Ann N Y Acad Sci. 2001;931:310341.CrossRefGoogle ScholarPubMed
86.Wigal, S, Wigal, T, Kollins, S. Advances in methylphenidate drug delivery systems for ADHD therapy. Advances in ADHD. 2006;1:47.Google Scholar
87.Biederman, J, Monuteaux, M, Mick, E, et al.Young adult outcome of attention deficit hyperactivity disorder: a controlled 10 year follow-up study. Psychol Med. 2006;36:167179.CrossRefGoogle ScholarPubMed
88.Kessler, RC, Adler, L, Barkle, R, et al.the prevalence and correlates of adult ADHD in the United States: results from the National Comorbidity Survey Replication. Am J Psychiatry. 2006;163:716723.CrossRefGoogle ScholarPubMed
89.Milstein, RB, Wilens, TE, Biederman, J, et al.Presenting ADHD symptoms and subtypes in clinically referred adults with ADHD. J Atten Disord. 1997;2:159166.CrossRefGoogle Scholar
90.McGough, JJ, Smalley, SL, McCracken, JT, et al.Psychiatric comorbidity in adult attention deficit hyperactivity disorder: findings from multiplex families. Am J Psychiatry. 2005;162:16211627.CrossRefGoogle ScholarPubMed
91.Biederman, J, Faraone, SV, Spencer, T, et al.Functional impairments in adults with self-reports of diagnosed ADHD: a controlled study of 1001 adults in the community. J Clin Psychiatry. 2006;67:524540.CrossRefGoogle ScholarPubMed
92.Faraone, SV, Sergeant, J, Gillberg, C, et al.The worldwide prevalence of ADHD: is it an American condition? World Psychiatry. 2003;163:716723.Google Scholar
93.Borland, BL, Heckman, HK. Hyperactive boys and their brothers: a 25-year follow-up study. Arch Gen Psychiatry. 1976;33:669675.CrossRefGoogle Scholar
94.Morrison, JR. Childhood hyperactivity in an adult psychiatric population: social factors. J Clin Psychiatry. 1980;41:4043.Google Scholar
95.Wilens, TE, Biederman, J, Mick, E. Does ADHD affect the course of substance abuse? Findings from a sample of adults with and without ADHD. Am J Addict. 1998;7:156163.Google ScholarPubMed
96.Tarter, RE. Psychosocial history, minimal brain dysfunction and differential drinking patterns of male alcoholics. J Clin Psychol. 1982;38:867873.3.0.CO;2-Y>CrossRefGoogle ScholarPubMed
97.Murphy, K, Barkley, RA. Attention deficit hyperactivity disorder adults comorbidities and adaptive impairments. Compr Psychiatry. 1996;37:393401.CrossRefGoogle ScholarPubMed
98.Barkley, RA, Fischer, M, Fletcher, K, et al.Persistence of attention deficit hyperactivity disorder into adulthood as a function of reporting source and definition of disorder. J Abnorm Psychol. 2002;111:279289.CrossRefGoogle ScholarPubMed
99.Weiss, M, Murray, C. Assessment and management of attention-deficit hyperactivity disorder in adults. CMAJ. 2003;168:715722.Google ScholarPubMed
100.Barkley, RA. Major life activity and health outcomes associated with attention deficit/hyperactivity disorder. J Clin Psychiatry. 2002;63(Suppl 12):10–5.Google ScholarPubMed
101.Shekin, WO, Asarnow, RF, Hess, E, et al.A clinical and demographic profile of a sample of adults with attention deficit hyperactivity disorder, residual state. Compr Psychiatry. 1990;31:416425.CrossRefGoogle Scholar
102.Biederman, J, Faraone, SV, Spencer, T, et al.Patterns of psychiatric comoribidty, cognition, and psychosocial funcitioning in adults with attention deficit hyperactivity disorder. Am J Psychiatry. 1993;150:17921798.Google ScholarPubMed
103.Kessler, RC, Berglund, P, Demler, O, Jin, R, Merikangas, KR, Walters, EE. Lifetime prevalence and age-of-onset distributions fDSM-IV disorders in the national Comorbidity Survey Replication. Arch Gen Psychiatry. 2005;62:593602.CrossRefGoogle ScholarPubMed
104.Wilens TE: Attention-deficit/hyperactivity disorder and the substance use disorders: the nature of the relationship, subtypes at risk, and treatment issues. Psychiatr Clin North Am. 2004;27:283301.CrossRefGoogle Scholar
105.Rush, CR, Higgins, ST, Vansickel, AR, Stoops, WW, Lile, JA, Glaser, PE. Methylphenidate increases cigarette smoking. Psychopharmacology (Berl). 2005;181:781789.CrossRefGoogle ScholarPubMed
106.Wilens, TE, Faraone, SV, Biederman, J, Gunawardene, S. Does stimulant therapy of attention-deficit/hyperactivity disorder beget later substance abuse? A meta-analytic review of the literature. Pediatrics. 2003;11:179185.CrossRefGoogle Scholar
107.Sobanski, E. Pschiatric comorbidity in adults with attention-deficity/hyperactivity disorder (ADHD). Eur Arch Psychiatry Clin Neurosci. 2006;256:2631.CrossRefGoogle Scholar
108.Wender, PH, Reimherr, FW, Wood, D, Ward, M. A controlled study of methylphenidate in the treatment of attention deficit disorder, residual type, in adults. Am J Psychiatry. 1985:142:547552.Google ScholarPubMed
109.Markowitz, JS. Drug interactions with stimulant medications. Int Clin Psychopharmacol. 1999;14:118.CrossRefGoogle Scholar
110.Greenhill, LL, Pliszka, S, Dulcan, MK, et al.Practice parameter for the use of stimulant mediaction in the treatment of children, adolescents and adults. J Am Acad Child Adolesc Psychiatry. 2002;41:26S49S.CrossRefGoogle Scholar
111.Nierenberg, AA, Mihahara, S, Spencer, T, et al.Clinical and diagnostic implications of lifetime comorbidity of attention-deficit/hyperactivity disorder in adults with bipolar disorder: data from the first 1000 STEP-BD participants. Biol Psychiatry. 2005:57;14671473.CrossRefGoogle ScholarPubMed
112.Brown, TE, McMullen, WJ. Attention deficit disorders and sleep/arousal disturbance. Ann NY Acad Sci. 2001;931:271286.CrossRefGoogle ScholarPubMed
113.Kooj, JJS, Huub, AM, Middelkoop, AM, Van Gils, K, Buitelaar, JK. The effect of stimulants on nocturnal activity and sleep quality in adults with ADHD: an open-label case-control study. J Clin Psychiatry. 2001;62:952955.CrossRefGoogle Scholar
114.Manuzza, S, Klein, RG, Bessler, A, Malloy, P, La Padula, M. Adult outcome of hyperactive boys. Educational achievement, occupational rank, and psychiatric status. Arch Gen Psychiatry. 1993;50:565567.CrossRefGoogle Scholar
115.Faraone, SV, Biederman, J, Doyle, A, et al.Neuropsychological Studies of Late Onset and Subthreshhold Diagnoses of Adult Attention-Deficit/Hyperactivity Disorder. Biol Psychiatry. 2006;60:10811087.CrossRefGoogle Scholar
116.Ward, MF, Wender, PH, Reimherr, FW. The Wender Utah Rating Scale: an aid in the retrospective diagnosis of childhood attention deficit hyperactivity disorder. Am J Psychiatry. 1993;150:885890.Google ScholarPubMed
117.Wender, PH. Attention-Deficit Hyperactivity Disorder in Adults. New York, NY: Oxford University Press; 1995.Google Scholar
118.Donnelly, C, Reimherr, F, Young, J. Differential diagnosis and treatment of adult ADHD and neighboring disorders. CNS Spectr. 2006;10(Suppl 11):116.Google Scholar
119.Wigal, T, Wigal, B, Steinhoff, K, et al.Establishing a clinical diagnosis of ADHD in adults: the QUEST method. Advances in ADHD. 2007. In press.Google Scholar
120.Safren, SA, Otto, MW, Sprich, S, Winett, CL, Wilens, TE, Biederman, J. Cognitive-behavioral therapy for ADHD in medication-treated adults with continued symptoms. Behav Res Ther. 2005;43(7):831842.CrossRefGoogle ScholarPubMed
121.Adler, LA, Spencer, TJ, Milton, DR, et al.Long-term, open-label study of the safety and efficacy of atomoxetine in adults with attention-deficit/hyperactivity disorder: an interim analysis. J Clin Psychiatry. 2005;66:294299.CrossRefGoogle ScholarPubMed
122.Michelson, D, Adler, L, Spencer, T, et al.Atomoxetine in adults with ADHD: two randomized, placebo-controlled trials. Biol Psychiatry. 2003;53:112120.CrossRefGoogle Scholar
123.Wilens, TE. Impact of ADHD and its treatment on substance abuse in adults. J Clin Psychiatry. 2004;65(Suppl 3);3845.Google ScholarPubMed
124.Allen, AJ, Kurlan, RM, Gilbert, DL, et al.Atomoxetine treatment in children and adolescents with ADHD and comorbid tic disorders. Neurology. 2005;65:19411949.CrossRefGoogle ScholarPubMed
125.Nissen, SE. ADHD and cardiovascular risk. N Engl J Med. 2006;354:14451448.CrossRefGoogle ScholarPubMed
126.Spencer, T, Biederman, J, Wilens, T, et al.A large, double-blind, randomized clinical trial of methylphenidate in the treatment of adults with attention-deficit/hyperactivity disorder. Biol Psychiatry. 2005;57:456463.CrossRefGoogle ScholarPubMed
127.Wender, EH. Managing stimulant medication for attention-deficit/hyperactivity disorder. Pediatr Rev. 2001;22:183189.CrossRefGoogle ScholarPubMed
128.Dexmethylphenidate (Focalin) for ADHD. Med Lett. 2002;44:4546.Google Scholar
129.Graydanus, DE, Sloane, MA, Rappley, MD. Psychopharmacology of ADHD in adolescents. Adolesc Med. 2002;3:599624.Google Scholar