Hostname: page-component-cd9895bd7-mkpzs Total loading time: 0 Render date: 2024-12-25T19:44:39.408Z Has data issue: false hasContentIssue false
  • English
  • Français

Summary of the Genetics of Obsessive-Compulsive Disorder Proceedings of the Third IOCDC

Published online by Cambridge University Press:  07 November 2014

Michele T. Pato ,
Carlos N. Pato ,
James L. Kennedy  and
David L. Pauls
Get access Rights & Permissions [Opens in a new window]

Abstract

The “Genetics of Obsessive-Compulsive Disorder” session at the Third International Obsessive-Compulsive Disorder Conference focused on the strong evidence of familial transmission of obsessive-compulsive disorder (OCD) and the new strategies available for molecular genetic research in this area. The opportunity to create a truly collaborative approach to the genetic study of OCD with standard methodology and large-scale cooperation among groups was emphasized. The importance of phenotype definition, including systematic subtyping, was discussed in the context of reducing heterogeneity and false-positive results.

Type
Academic Supplement Monograph
Information
CNS Spectrums , Volume 4 , supplement S3: The Third International Obsessive-Compulsive Disorder Conference , May 1999 , pp. 22 - 24
Copyright
Copyright © Cambridge University Press 1999

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

1.Alsobrook, JP II, Pauls, DL. The genetics of obsessive compulsive disorder. In: Jenike, MA, Baer, L, Minichiello, WE, eds. Obsessive-Compulsive Disorders: Theory and Management: A Guide for Clinicians, Patients and Families. 3rd ed. Littleton, MA: Year Book Medical Publishers, Inc; 1998.Google Scholar
2.Lenane, MG, Swedo, SE, Leonard, H, Pauls, DL, Sceery, W, Rapoport, J. Psychiatric disorders in first degree relatives of children and adolescents with obsessive-compulsive disorder. J Am Acad Child Adolesc Psychiatry. 1990;29:407–412.CrossRefGoogle ScholarPubMed
3.Leonard, HL, Lenane, MC, Swedo, SE, Reftew, DC, Gershon, ES, Rapoport, JL. Tics and Tourette's disorder: a 2- to 7-year follow-up of 54 obsessive-compulsive children. Am J Psychiatry. 1992;149:1244–1251.Google ScholarPubMed
4.Bellodi, L, Sciuto, G, Diaeria, G, Ronchi, P, Smeraidi, E. Psychiatric disorders in the families of patients with obsessive-compulsive disorder. Psychiatry Res. 1992;42:111–120.CrossRefGoogle ScholarPubMed
5.Black, DW, Noyes, R Jr, Goldstein, RB, Blum, N. A family study of obsessive-compulsive disorder. Arch Gen Psychiatry. 1992;49:362–368.CrossRefGoogle ScholarPubMed
6.Pauls, DL. Alsobrook, JP II, Goodman, W, Rasmussen, S, Leckman, JF. A family study of obsessive-compulsive disorder. Am J Psychiatry. 1995;152:76–84.Google ScholarPubMed
7.Nicolini, H, Hanna, G, Baxter, L, Schwartz, J, Weisbacker, K, Spence, MA. Segregation analysis of obsessive-compulsive and associated disorders. Preliminary results. Ursus Med. 1991;1:25–28.Google Scholar
8.Cavalini, MC, Macciardi, F, Pasquale, L, Bellodi, L, Smeraidi, E. Complex segregation analysis of obsessive-compulsive and spectrum related disorders. Psychiatr Genet. 1995;5(suppl 1):s31.Google Scholar
9.Alsobrook, JP II, Leckman, JF, Goodman, WK, Rasmussen, SA, Pauls, DL. A mendelian form of obsessive-compulsive disorder derived from symptom-based factors. Am J Med Genet. In press.Google Scholar
10.Zohar, J, Insel, TR. Obsessive-compulsive disorder: psychobiological approaches to diagnosis, treatment and pathophysiology. Biol Psychiatry. 1987;2:667–687.CrossRefGoogle Scholar
11.Goodman, WK, McDougle, CJ, Price, LH, Riddle, MA, Pauls, DL, Leckman, JF. Beyond the serotonin hypothesis: a role for dopamine in some forms of obsessive-compulsive disorder? J Clin Psychiatry. 1990;51(suppl i):36–43.Google ScholarPubMed
12.Hanna, GL, McCracken, JT, Cantwell, DP. Prolactin in childhood obsessive compulsive disorder: clinical correlates and response to clomipramine. J Am Acad Child Adolesc Psychiatry. 1991;30:173–178.CrossRefGoogle ScholarPubMed
13.McDougle, CJ, Goodman, WK, Leckman, JF, Barr, LC, Heninger, GR, Price, LH. The efficacy of fluvoxamine in obsessive-compulsive disorder: effects of comorbid chronic tic disorder. J Clin Psychopharmacology. 1993;13:354–358.CrossRefGoogle ScholarPubMed
14.McDougle, CJ, Goodman, WK, Leckman, JF, Lee, NC, Heninger, GR, Price, LH. Haloperidol addition in fluvoxamine-refractory obsessive compulsive disorder: a double blind placebo-controlled study in patients with and without tics. Arch Gen Psychiatry. 1994;51:302–308.CrossRefGoogle ScholarPubMed
15.Altemus, M, Pigott, T, Kalogeras, KT, et al.Abnormalities in the regulation of vasopressin and corticotropin releasing factor secretion in obsessive-compulsive disorder. Arch Gen Psychiatry. 1992;49:9–20.CrossRefGoogle ScholarPubMed
16.de Boer, JA, Westenberg, HGM. Oxytocin in obsessive-compulsive disorder. Peptides. 1992;13;1083–1085.CrossRefGoogle Scholar
17.Leckman, JF, Goodman, WK, North, WG, et al.Elevated levels of CSF oxytocin in obsessive compulsive disorder: comparison with Tourette's syndrome and healthy controls. Arch Gen Psychiatry. 1994;51:782–792.CrossRefGoogle ScholarPubMed
18.Leckman, JF, Goodman, WK, North, WG, et al.The role of central oxytocin in obsessive compulsive disorder and related normal behavior. Psychoneuroendocrinology. 1994;19:723–749.CrossRefGoogle ScholarPubMed
19.Altemus, M, Murphy, DL, Greenberg, B, Lesch, KP. Intact coding region of serotonin transporter gene in obsessive-compulsive disorder. Am J Med Genet. 1996;67:409–411.3.0.CO;2-N>CrossRefGoogle ScholarPubMed
20.Di Bella, D, Catalano, M, Balling, U, Smeraldi, E, Lesch, K. Systematic screening for mutations in the coding region of the human serotonin transporter (5BHTT) gene using PCR and DGGE. Am J Med Genet. 1996;67:541–545.3.0.CO;2-K>CrossRefGoogle ScholarPubMed
21.Di Bella, D, Catalano, M, Cichon, S, Nothen, MM. Association study of a null mutation in the dopamine D4 receptor gene in Italian patients with obsessive-compulsive disorder, bipolar mood disorder and schizophrenia. Psychiatr Genet. 1996;6:119–121.CrossRefGoogle Scholar
22.Karayiorgou, M, Altemus, M. Galke, B, et al.Genotype determining low catechol-O-methyltransferase activity as a risk factor for obsessive-compulsive disorder. Proceedings of the National Academy of Sciences. 1997;94:4572–4575.CrossRefGoogle ScholarPubMed
23.Billett, EA, Richter, MA, Kennedy, JL. Genetics of obsessive-compulsive disorder. In: Swinson, RP, Antony, MM, Rachman, J, Richter, MM, eds. Obsessive Compulsive Disorder: Theory, Research and Treatment. New York, NY: Guilford Press; 1998:181–205.Google Scholar