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Theta Burst Stimulation in the Treatment of Incapacitating Tinnitus Accompanied by Severe Depression

Published online by Cambridge University Press:  07 November 2014

Surjo R. Soekadar ,
Carola Arfeller ,
Albrecht Rilk ,
Stefan K. Plontke  and
Christian Plewnia
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Abstract

This case report describes the use of transcranial magnetic theta burst stimulation (TBS) in the treatment of incapacitating tinnitus accompanied by symptoms of severe depression. Tinnitus is known to be associated with hyperactivity and maladaptive cortical reorganization of the central auditory system. Combined with anxiety and depression, it can occasionally constitute a psychiatric emergency. Recently, it has been demonstrated that tinnitus can be temporarily suppressed by non-invasive transcranial magnetic stimulation. TBS is a newly developed technique for rapid and lasting modulation of cortical excitability. Herein, we present a case of a 54-year-old woman with incapacitating tinnitus that has significantly decreased after three cycles of 1-week treatment with continuous TBS to the temporo-parietal auditory association cortex. According to the Tinnitus Questionnaire, tinnitus intensity decreased from 84 points before to 59 points after treatment. Hamilton Rating Scale for Depression score dropped from 44 to 23 points. TBS showed to be efficient, well-tolerated, and practical in the management of distressing tinnitus accompanied by symptoms of severe depression.

Type
Case Report
Information
CNS Spectrums , Volume 14 , Issue 4 , April 2009 , pp. 208 - 213
Copyright
Copyright © Cambridge University Press 2009

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References

REFERENCES

1.Fitzgerald, PB, Hoy, K, McQueen, S, et al.A Randomized trial of rTMS targeted with MRI based neuro-navigation in treatment-resistant Ddepression. Neuropsychopharmacology. 2009 Jan 14. [Epub ahead of print].Google Scholar
2.Mantovani, A, Lisanby, SH, Pieraccini, F, Ulivelli, M, Castrogiovanni, P, Rossi, S. Repetitive transcranial magnetic stimulation (rTMS) in the treatment of obsessive-compulsive disorder (OCD) and Tourette's syndrome (TS). Int J Neuropsychopharmacol. 2006;9:95–100.Google Scholar
3.Pleger, B, Janssen, F, Schwenkreis, P, Völker, B, Maier, C, Tegenthoff, M. Repetitive transcranial magnetic stimulation of the motor cortex attenuates pain perception in complex regional pain syndrome type I. Neurosci Lett. 2004;356:87–90.CrossRefGoogle ScholarPubMed
4.Murase, N, Rothwell, JC, Kaji, R, et al.Subthreshold low-frequency repetitive transcranial magnetic stimulation over the premotor cortex modulates writer's cramp. Brain. 2005;128:104–115.Google Scholar
5.Huang, YZ, Edwards, MJ, Rounis, E, Bhatia, KP, Rothwell, JC. Theta burst stimulation of the human motor cortex. Neuron. 2005;45:201–206.Google Scholar
6.Huang, YZ, Chen, RS, Rothwell, JC, Wen, HY. The after-effect of human theta burst stimulation is NMDA receptor dependent. Clin Neurophysiol. 2007;118:1028–1032.Google Scholar
7.Schindler, K, Nyffeler, T, Wiest, R, Hauf, M, Mathis, J, Hess, CW, Müri, R. Theta burst transcranial magnetic stimulation is associated with increased EEG synchronization in the stimulated relative to unstimulated cerebral hemisphere. Neurosci Lett. 2008;436:31–34.CrossRefGoogle ScholarPubMed
8.Paulus, W. Toward establishing a therapeutic window for rTMS by theta burst stimulation. Neuron. 2005;45:181–183.Google Scholar
9.Talelli, P, Greenwood, RJ, Rothwell, JC. Exploring Theta Burst Stimulation as an intervention to improve motor recovery in chronic stroke. Clin Neurophysiol. 2007;118:333–342.Google Scholar
10.Di Lazzaro, V, Dileone, M, Pilato, F, et al.Repetitive transcranial magnetic stimulation for ALS. A preliminary controlled study. Neurosci Lett. 2006;408:135–140.Google Scholar
11.Lockwood, AH, Salvi, RJ, Coad, ML, Towsley, ML, Wack, DS, Murphy, BW. The functional neuroanatomy of tinnitus: evidence for limbic system links and neural plasticity. Neurology. 1998;50:114–120.CrossRefGoogle ScholarPubMed
12.Giraud, AL, Chery-Croze, S, Fischer, G, et al.A selective imaging of tinnitus. Neuroreport. 1999;10:1–5.Google Scholar
13.Plewnia, C, Reimold, M, Najib, A, et al.Dose-dependent attenuation of auditory phantom perception (tinnitus) by PET-guided repetitive transcranial magnetic stimulation. Hum Brain Mapp. 2007;28:238–246.CrossRefGoogle ScholarPubMed
14.Plewnia, C, Reimold, M, Najib, A, Reischl, G, Plontke, SK, Gerloff, C. Moderate therapeutic efficacy of positron emission tomography-navigated repetitive transcranial magnetic stimulation for chronic tinnitus: a randomised, controlled pilot study. J Neurol Neurosurg Psychiatry. 2007;78:152–156.CrossRefGoogle ScholarPubMed
15.Plewnia, C, Bartels, M, Gerloff, C. Transient suppression of tinnitus by transcranial magnetic stimulation. Ann Neurol. 2003;53:263–266.Google Scholar
16.De Ridder, D, De Mulder, G, Walsh, V, Muggleton, N, Sunaert, S, Moller, A. Magnetic and electrical stimulation of the auditory cortex for intractable tinnitus. Case report. J Neurosurg. 2004;100:560–564.Google Scholar
17.Fregni, F, Marcondes, R, Boggio, PS, et al.Transient tinnitus suppression induced by repetitive transcranial magnetic stimulation and transcranial direct current stimulation. Eur J Neurol. 2006;13:996–1001.CrossRefGoogle ScholarPubMed
18.Langguth, B, Kleinjung, T, Marienhagen, J, et al.Transcranial magnetic stimulation for the treatment of tinnitus: effects on cortical excitability. BMC Neurosci. 2007;8:45.CrossRefGoogle ScholarPubMed
19.Hamilton, . A Rating Scale for Depression. J. Neurol. Neurosurg. Psychiat. 1960;23:56–62.Google Scholar
20.Goebel, G, Hiller, W. The tinnitus questionnaire. A standard instrument for grading the degree of tinnitus. Results of a multicenter study with the tinnitus questionnaire [German]. HNO. 1994;42:166–172.Google Scholar
21.Hiller, W, Goebel, G, Rief, W. Reliability of self-rated tinnitus distress and association with psychological symptom patterns. Br J Clin Psychol. 1994;33:231–239.Google Scholar
22.Zenner, HP, De Maddalena, H. Validity and reliability study of three tinnitus self-assessment scales: loudness, annoyance and change. Acta Otolaryngol. 2005;125:1184–1188.CrossRefGoogle ScholarPubMed
23.Duckert, LG, Rees, TS. Placebo effect in tinnitus management. Otolaryngol Head Neck Surg. 1984;92:697–699.Google Scholar