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Treating Schizophrenia Now and Developing Strategies for the Next Decade

Published online by Cambridge University Press:  07 November 2014

Carol A. Tamminga
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Abstract

This paper focuses on treatments for schizophrenia (SZ)—treatments we have now and those we hope to have in the future. The treatments we have are based on serendipity, but are effective nonetheless. Pharmacologic characteristics of the most-prescribed drugs are reviewed. It is apparent that a spectrum of effective drugs exist to support individualized therapy. With a view to future discovery, a strategy is proposed for rational antipsychotic drug development. A few concrete examples from the author's own laboratory illustrate an application of the proposal. These data would support the existence of a drugtarget in the anterior cingulate and/or hippocampal cortex. The studies suggest a focus on the limbic cortex for SZ pathophysiology. It would depend on future discovery to test whether this proposal will be productive. For sure, the rapid advance of basic neuroscience provides untold promise for the future.

Type
Feature Articles
Information
CNS Spectrums , Volume 6 , Issue 12: The White Paper Issue 2001 , December 2001 , pp. 987 - 991, 1000
Copyright
Copyright © Cambridge University Press 2001

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