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Multiphysics Modeling of Liver Tumor Ablation by High Intensity Focused Ultrasound

Part of: Thermodynamics and heat transfer Partial differential equations, boundary value problems

Published online by Cambridge University Press:  15 October 2015

Maxim Solovchuk ,
Tony Wen-Hann Sheu  and
Marc Thiriet
Maxim Solovchuk*
Affiliation:
Center of Advanced Study in Theoretical Sciences (CASTS), National Taiwan University Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, No. 35, Keyan Road, Zhunan, Taiwan 35053
Tony Wen-Hann Sheu*
Affiliation:
Center of Advanced Study in Theoretical Sciences (CASTS), National Taiwan University Department of Engineering Science and Ocean Engineering, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei, Taiwan 10617
Marc Thiriet
Affiliation:
Sorbonne Universities, UPMC Univ Paris 06, UMR 7598, Laboratoire Jacques-Louis Lions, F-75005, Paris, France
*
*Corresponding author. Email addresses: solovchuk@gmail.com (M. Solovchuk), twhsheu@ntu.edu.tw (T. W.-H. Sheu), marc.thiriet@inria.fr (M. Thiriet)
*Corresponding author. Email addresses: solovchuk@gmail.com (M. Solovchuk), twhsheu@ntu.edu.tw (T. W.-H. Sheu), marc.thiriet@inria.fr (M. Thiriet)
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Abstract

High intensity focused ultrasound is a rapidly developing technology for the ablation of tumors. Liver cancer is one of the most common malignancies worldwide. Since liver has a large number of blood vessels, blood flow cooling can reduce the necrosed volume and may cause regeneration of the tumor to occur. All cancer cells should be ablated without damaging of the critical tissues. Today, treatment planning tools consider liver as a homogeneous organ. This paper is a step towards the development of surgical planning platform for a non-invasive HIFU tumor ablative therapy in a real liver geometry based on CT/MRI image. This task requires coupling of different physical fields: acoustic, thermal and hydrodynamic. These physical fields can influence each other. In this paper we illustrate how a computational model can be used to improve the treatment efficiency. In large blood vessel both convective cooling and acoustic streaming can change the temperature considerably near blood vessel. The whole tumor ablation took only 30 seconds in the considered simulation case, which is very small comparing with the current treatment time of several hours. Through this study we are convinced that high ultrasound power and nonlinear propagation effects with appropriate treatment planning can sufficiently reduce the treatment time.

Keywords

Multiphysics and multiscale modelliver tumorcomputational surgeryblood flowfocused ultrasound

MSC classification

Secondary: 80A20: Heat and mass transfer, heat flow 65Z05: Applications to physics 68U20: Simulation 65N06: Finite difference methods
Type
Research Article
Information
Communications in Computational Physics , Volume 18 , Issue 4 , October 2015 , pp. 1050 - 1071
Copyright
Copyright © Global-Science Press 2015 

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