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The neurobiological basis of autism from a developmental perspective

Published online by Cambridge University Press:  20 August 2002

NATACHA AKSHOOMOFF ,
KAREN PIERCE  and
ERIC COURCHESNE
NATACHA AKSHOOMOFF
Affiliation:
Children's Hospital Research Center and University of California
KAREN PIERCE
Affiliation:
Children's Hospital Research Center and University of California
ERIC COURCHESNE
Affiliation:
Children's Hospital Research Center and University of California
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Extract

Autism is a neurobiological disorder that is diagnosed through careful behavioral assessment in early childhood. In this paper, we review recent studies that have attempted to reveal the underlying causes of autism using a variety of techniques. Particular emphasis is placed on techniques that have been used by a number of different laboratories, including structural magnetic resonance imaging and postmortem studies of neuroanatomy. Neurobiological and neuropsychological data from individuals across a wide age range are examined from a neurodevelopmental perspective. We discuss how these recent advances have led us to develop a growth dysregulation hypothesis of autism. Finally, we discuss how this hypothesis may lead to new innovations in autism research.

Type
Research Article
Information
Development and Psychopathology , Volume 14 , Issue 3 , September 2002 , pp. 613 - 634
Copyright
© 2002 Cambridge University Press

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