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Vulnerability to depression: A moderated mediation model of the roles of child maltreatment, peer victimization, and serotonin transporter linked polymorphic region genetic variation among children from low socioeconomic status backgrounds

Published online by Cambridge University Press:  23 July 2013

Adrienne M. Banny ,
Dante Cicchetti ,
Fred A. Rogosch ,
Assaf Oshri  and
Nicki R. Crick
Adrienne M. Banny*
Affiliation:
University of Minnesota
Dante Cicchetti*
Affiliation:
University of Minnesota University of Rochester
Fred A. Rogosch
Affiliation:
University of Rochester
Assaf Oshri
Affiliation:
University of Rochester
Nicki R. Crick
Affiliation:
University of Minnesota
*
Address correspondence and reprint requests to: Adrienne M. Banny or Dante Cicchetti, Institute of Child Development, University of Minnesota, 51 East River Road, Minneapolis, MN 55455; E-mail: banny001@umn.edu or cicchett@umn.edu.
Address correspondence and reprint requests to: Adrienne M. Banny or Dante Cicchetti, Institute of Child Development, University of Minnesota, 51 East River Road, Minneapolis, MN 55455; E-mail: banny001@umn.edu or cicchett@umn.edu.
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Abstract

Child maltreatment, peer victimization, and a polymorphism of the serotonin transporter gene (5-HTTLPR) were examined as predictors of depressive symptomatology. Children (M age = 11.26, SD = 1.65), including 156 maltreated and 145 nonmaltreated children from comparable low socioeconomic backgrounds, provided DNA samples and self-reports of relational peer victimization, overt peer victimization, and depressive symptoms. Path analysis showed that relational and overt victimization mediated the association between child maltreatment and depressive symptoms. Bootstrapping procedures were used to test moderated mediation and demonstrated that genotype moderated the indirect effects of relational and overt victimization on child depressive symptoms, such that victimized children with the long/long variation were at an increased risk for depressive symptoms compared to victimized children carrying a short allele. Results highlight the utility of examining process models that incorporate biological and psychological factors contributing to the development of depressive symptomatology and provide direction toward understanding and promoting resilience among high-risk youth from a multiple levels of analysis approach.

Type
Regular Articles
Information
Development and Psychopathology , Volume 25 , Issue 3 , August 2013 , pp. 599 - 614
Copyright
Copyright © Cambridge University Press 2013 

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