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Attention deficits and hyperactivity–impulsivity: What have we learned, what next?

Published online by Cambridge University Press:  17 December 2013

Joel T. Nigg
Joel T. Nigg*
Affiliation:
Oregon Health and Science University
*
Address correspondence and reprint requests to: Joel T. Nigg, Department of Psychiatry, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239-3098; E-mail: niggj@ohsu.edu.
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Abstract

The domains of self-regulation, self-control, executive function, inattention, and impulsivity cut across broad swathes of normal and abnormal development. Attention-deficit/hyperactivity disorder is a common syndrome that encompasses a portion of these domains. In the past 25 years research on attention-deficit/hyperactivity disorder has been characterized by dramatic advances in genetic, neural, and neuropsychological description of the syndrome as well as clarification of its multidimensional phenotypic structure. The limited clinical applicability of these research findings poses the primary challenge for the next generation. It is likely that clinical breakthroughs will require further refinement in describing heterogeneity or clinical/biological subgroups, renewed focus on the environment in the form of etiological events as well as psychosocial contexts of development, and integration of both with biological understanding.

Type
Regular Articles
Information
Development and Psychopathology , Volume 25 , Issue 4pt2: Development and Psychopathology: A Vision Realized , November 2013 , pp. 1489 - 1503
Copyright
Copyright © Cambridge University Press 2013 

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References

Agosti, V., Chen, Y., & Levin, F. R. (2011). Does attention deficit hyperactivity disorder increase the risk of suicide attempts? Journal of Affective Disorders, 133, 595–599.Google Scholar
Allis, C. D., Jenuwein, T., & Reinberg, D. (2007). Epigenetics. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.Google Scholar
Barker, E. D., Tremblay, R. E., van Lier, P. A., Vitaro, F., Nagin, D. S., Assaad, J. M., et al. (2011). The neurocognition of conduct disorder behaviors: Specificity to physical aggression and theft after controlling for ADHD symptoms. Aggressive Behavior, 37, 63–72. doi:10.1002/ab.20373CrossRefGoogle ScholarPubMed
Barkley, R. A. (2011). Distinguishing sluggish cognitive tempo from attention-deficit/hyperactivity disorder in adults. Journal of Abnormal Psychology. Advance online publication. doi:10.1037/a00239612011-10368-001Google Scholar
Barkley, R. A. (2012). Distinguishing sluggish cognitive tempo from attention-deficit/hyperactivity disorder in adults. Journal of Abnormal Psychology, 121, 978–990. doi:10.1037/a00239612011-10368-001Google Scholar
Barry, R. J., Johnstone, S. J., & Clarke, A. R. (2003). A review of electrophysiology in attention-deficit/hyperactivity disorder: II. Event-related potentials. Clinical Neurophysiology, 114, 184–198. doi:S1388245702003632Google Scholar
Bauermeister, J. J., Barkley, R. A., Bauermeister, J. A., Martinez, J. V., & McBurnett, K. (2011). Validity of the sluggish cognitive tempo, inattention, and hyperactivity symptom dimensions: Neuropsychological and psychosocial correlates. Journal of Abnormal Child Psychology. Advance online publication. doi:10.1007/s10802-011-9602-7Google Scholar
Bauermeister, J. J., Canino, G., Polanczyk, G., & Rohde, L. A. (2010). ADHD across cultures: Is there evidence for a bidimensional organization of symptoms? Journal of Clinical and Child Adolescent Psychology, 39, 362–372.CrossRefGoogle ScholarPubMed
Beauchaine, T. P., & Gatzke-Kopp, L. M. (2012). Instantiating the multiple levels of analysis perspective in a program of study on externalizing behavior. Development and Psychopathology, 24, 1003–1018. doi:10.1017/S0954579412000508CrossRefGoogle Scholar
Belsky, J., & Pluess, M. (2009). Beyond diathesis stress: Differential susceptibility to environmental influences. Psychological Bulletin, 135, 885–908. doi:10.1037/a0017376Google Scholar
Bergman, L. R., Andershed, H., & Andershed, A. K. (2009). Types and continua in developmental psychopathology: Problem behaviors in school and their relationship to later antisocial behavior. Developmental Psychopathology, 21, 975–992. doi:10.1017/S0954579409000522Google Scholar
Blair, C., & Razza, R. P. (2007). Relating effortful control, executive function, and false belief understanding to emerging math and literacy ability in kindergarten. Child Development, 78, 647–663.CrossRefGoogle ScholarPubMed
Boyle, C. A., Boulet, S., Schieve, L. A., Cohen, R. A., Blumberg, S. J., Yeargin-Allsopp, M., et al. (2011). Trends in the prevalence of developmental disabilities in US children, 1997–2008. Pediatrics, 127, 1034–1042. doi:10.1542/peds.2010-2989CrossRefGoogle ScholarPubMed
Bradley, C. (1937). The behaviour of children receiving Benzedrine. American Journal of Psychiatry, 94, 577–585.Google Scholar
Braun, J. M., Kahn, R. S., Froehlich, T., Auinger, P., & Lanphear, B. P. (2006). Exposures to environmental toxicants and attention deficit hyperactivity disorder in U.S. children. Environmental Health Perspectives, 114, 1904–1909.CrossRefGoogle ScholarPubMed
Burnette, M. L., & Cicchetti, D. (2012). Multilevel approaches toward understanding antisocial behavior: Current research and future directions. Development and Psychopathology, 24, 703–704. doi:10.1017/S0954579412000314Google Scholar
Burns, G. L., Walsh, J. A., Gomez, R., & Hafetz, N. (2006). Measurement and structural invariance of parent ratings of ADHD and ODD symptoms across gender for American and Malaysian children. Psychological Assessment, 18, 452–457. doi:10.1037/1040-3590.18.4.452Google Scholar
Bush, G. (2011). Cingulate, frontal, and parietal cortical dysfunction in attention-deficit/hyperactivity disorder. Biological Psychiatry, 69, 1160–1167. doi:10.1016/j.biopsych.2011.01.022Google Scholar
Calkins, S. D., & Keane, S. P. (2009). Developmental origins of early antisocial behavior. Development and Psychopathology, 21, 1095–1109.Google Scholar
Canino, G., & Alegria, M. (2008). Psychiatric diagnosis—Is it universal or relative to culture? Journal of Child Psychology and Psychiatry, 49, 237–250. doi:10.1111/j.1469-7610.2007.01854.xGoogle Scholar
Castellanos, F. X., & Hyde, Z. (2010). Diffusion tensor imaging provides new clues in adults with ADHD (Commentary on Konrad et al.). European Journal of Neuroscience, 31, 910–911. doi:10.1111/j.1460-9568.2010.07173.xCrossRefGoogle ScholarPubMed
Castellanos, F. X., Lee, P. P., Sharp, W., Jeffries, N. O., Greenstein, D. K., Clasen, L. S., et al. (2002). Developmental trajectories of brain volume abnormalities in children and adolescents with attention-deficit/hyperactivity disorder. Journal of the American Medical Association, 288, 1740–1748. doi:joc20194Google Scholar
Castellanos, F. X., Margulies, D. S., Kelly, C., Uddin, L. Q., Ghaffari, M., Kirsch, A., et al. (2008). Cingulate–precuneus interactions: A new locus of dysfunction in adult attention-deficit/hyperactivity disorder. Biological Psychiatry, 63, 332–337. doi:10.1016/j.biopsych.2007.06.025CrossRefGoogle ScholarPubMed
Castellanos, F. X., Sonuga-Barke, E. J., Scheres, A., Di Martino, A., Hyde, C., & Walters, J. R. (2005). Varieties of attention-deficit/hyperactivity disorder-related intra-individual variability. Biological Psychiatry, 57, 1416–1423. doi:10.1016/j.biopsych.2004.12.005Google Scholar
Cicchetti, D., & Cannon, T. D. (1999). Neurodevelopmental processes in the ontogenesis and epigenesis of psychopathology. Devopment and Psychopathology, 11, 375–393.Google Scholar
Cicchetti, D., & Posner, M. I. (2005). Cognitive and affective neuroscience and developmental psychopathology. Development and Psychopathology, 17, 569–575. doi:10.1017/S0954579405050273CrossRefGoogle ScholarPubMed
Cicchetti, D., & Richters, J. E. (1997). Examining the conceptual and scientific underpinnings of research in developmental psychopathology. Development and Psychopathology, 9, 189–191.CrossRefGoogle ScholarPubMed
Cicchetti, D., & Toth, S. L. (2009). The past achievements and future promises of developmental psychopathology: The coming of age of a discipline. Journal of Child Psychology and Psychiatry, 50, 16–25. doi:10.1111/j.1469-7610.2008.01979.xGoogle Scholar
Clausen, J. A. (1993). American lives. New York: Free Press.Google Scholar
Colombo, J., Kannass, K. N., Shaddy, D. J., Kundurthi, S., Maikranz, J. M., Anderson, C. J., et al. (2004). Maternal DHA and the development of attention in infancy and toddlerhood. Child Development, 75, 1254–1267. doi:10.1111/j.1467-8624.2004.00737.xCDEV737Google Scholar
Cortese, S., Kelly, C., Chabernaud, C., Proal, E., Di Martino, A., Milham, M. P., et al. (2012). Toward systems neuroscience of ADHD: A meta-analysis of 55 fMRI studies. American Journal of Psychiatry, 169, 1038–1055. doi:10.1176/appi.ajp.2012.11101521Google Scholar
Cortese, S., & Morcillo Penalver, C. (2010). Comorbidity between ADHD and obesity: Exploring shared mechanisms and clinical implications. Postgraduate Medicine, 122, 88–96. doi:10.3810/pgm.2010.09.2205CrossRefGoogle ScholarPubMed
Deyoung, C. G., & Clark, R. (2012). The gene in its natural habitat: The importance of gene–trait interactions. Development and Psychopathology, 24, 1307–1318. doi:10.1017/S0954579412000727Google Scholar
Dickstein, S. G., Bannon, K., Castellanos, F. X., & Milham, M. P. (2006). The neural correlates of attention deficit hyperactivity disorder: An ALE meta-analysis. Journal of Child Psychology and Psychiatry, 47, 1051–1062. doi:10.1111/j.1469-7610.2006.01671.xGoogle Scholar
Dominguez-Salas, P., Cox, S. E., Prentice, A. M., Hennig, B. J., & Moore, S. E. (2012). Maternal nutritional status, C1 metabolism and offspring DNA methylation: A review of current evidence in human subjects. Proceedings of the Nutrition Society, 71, 154–165. doi:10.1017/S0029665111003338Google Scholar
D'Onofrio, B. M., Van Hulle, C. A., Waldman, I. D., Rodgers, J. L., Harden, K. P., Rathouz, P. J., et al. (2008). Smoking during pregnancy and offspring externalizing problems: An exploration of genetic and environmental confounds. Development and Psychopathology, 20, 139–164. doi:10.1017/S0954579408000072Google Scholar
Engel, S. M., Wetmur, J., Chen, J., Zhu, C., Barr, D. B., Canfield, R. L., et al. (2011). Prenatal exposure to organophosphates, paraoxonase 1, and cognitive development in childhood. Environmental Health Perspectives, 119, 1182–1188. doi:10.1289/ehp.1003183Google Scholar
Epstein, J. N., March, J. S., Conners, C. K., & Jackson, D. L. (1998). Racial differences on the Conners Teacher Rating Scale. Journal of Abnormal Child Psychology, 26, 109–118.CrossRefGoogle ScholarPubMed
Fair, D. A., Posner, J., Nagel, B. J., Bathula, D., Dias, T. G., Mills, K. L., et al. (2010). Atypical default network connectivity in youth with attention-deficit/hyperactivity disorder. Biological Psychiatry, 68, 1084–1091. doi:10.1016/j.biopsych.2010.07.003CrossRefGoogle ScholarPubMed
Feingold, B. F. (1975). Hyperkinesis and learning disabilities linked to artificial food flavors and colors. American Journal of Nursing, 75, 797–803.Google ScholarPubMed
Forero, D. A., Arboleda, G. H., Vasquez, R., & Arboleda, H. (2009). Candidate genes involved in neural plasticity and the risk for attention-deficit hyperactivity disorder: A meta-analysis of 8 common variants. Journal of Psychiatry and Neuroscience, 34, 361–366.Google ScholarPubMed
Frazier, T. W., Shattuck, P. T., Narendorf, S. C., Cooper, B. P., Wagner, M., & Spitznagel, E. L. (2011). Prevalence and correlates of psychotropic medication use in adolescents with an autism spectrum disorder with and without caregiver-reported attention-deficit/hyperactivity disorder. Journal of Child and Adolescent Psychopharmacology, 21, 571–579. doi:10.1089/cap.2011.0057CrossRefGoogle ScholarPubMed
Frazier, T. W., Youngstrom, E. A., Naugle, R. I., Haggerty, K. A., & Busch, R. M. (2007). The latent structure of cognitive symptom exaggeration on the Victoria Symptom Validity Test. Archives of Clinical Neuropsychology, 22, 197–211. doi:10.1016/j.acn.2006.12.007Google Scholar
Gale, C. R., Robinson, S. M., Godfrey, K. M., Law, C. M., Schlotz, W., & O'Callaghan, F. J. (2008). Oily fish intake during pregnancy—Association with lower hyperactivity but not with higher full-scale IQ in offspring. Journal of Child Psychology and Psychiatry, 49, 1061–1068. doi:10.1111/j.1469-7610.2008.01908.xGoogle Scholar
Gatzke-Kopp, L. M. (2011). The canary in the coalmine: The sensitivity of mesolimbic dopamine to environmental adversity during development. Neuroscience & Biobehavioral Reviews, 35, 794–803. doi:10.1016/j.neubiorev.2010.09.013Google Scholar
Gizer, I. R., Ficks, C., & Waldman, I. D. (2009). Candidate gene studies of ADHD: A meta-analytic review. Human Genetics, 126, 51–90. doi:10.1007/s00439-009-0694-xGoogle Scholar
Gluckman, P. D., Hanson, M. A., & Low, F. M. (2011). The role of developmental plasticity and epigenetics in human health. Birth Defects Research, 93C, 12–18. doi:10.1002/bdrc.20198Google Scholar
Gomez, R. (2009). Invariance of parent ratings of the ADHD symptoms in Australian and Malaysian, and north European Australian and Malay Malaysia children: A mean and covariance structures analysis approach. Journal of Attention Disorders, 12, 422–433. doi:10.1177/1087054708315171Google Scholar
Grayton, H. M., Fernandes, C., Rujescu, D., & Collier, D. A. (2012). Copy number variations in neurodevelopmental disorders. Progress in Neurobiology, 99, 81–91. doi:10.1016/j.pneurobio.2012.07.005S0301-0082(12)00113-XGoogle Scholar
Grigorenko, E. L., & Cicchetti, D. (2012). Genomic sciences for developmentalists: The current state of affairs. Developmental Psychopathology, 24, 1157–1164. doi:10.1017/S0954579412000612S0954579412000612Google Scholar
Harris, A., & Seckl, J. (2011). Glucocorticoids, prenatal stress and the programming of disease. Hormones and Behavior, 59, 279–289. doi:10.1016/j.yhbeh.2010.06.007CrossRefGoogle ScholarPubMed
Haynes, K. A., & Silver, P. A. (2011). Synthetic reversal of epigenetic silencing. Journal of Biology and Chemistry, 286, 27176–27182. doi:10.1074/jbc.C111.229567Google Scholar
Huang-Pollock, C. L., Carr, T. H., & Nigg, J. T. (2002). Development of selective attention: Perceptual load influences early versus late attentional selection in children and adults. Developmental Psychology, 38, 363–375.Google Scholar
Huang-Pollock, C. L., & Nigg, J. T. (2003). Searching for the attention deficit in attention deficit hyperactivity disorder: The case of visuospatial orienting. Clinical Psychology Review, 23, 801–830.Google Scholar
Huang-Pollock, C. L., Nigg, J. T., & Carr, T. H. (2005). Deficient attention is hard to find: Applying the perceptual load model of selective attention to attention deficit hyperactivity disorder subtypes. Journal of Child Psychology and Psychiatry, 46, 1211–1218. doi:10.1111/j.1469-7610.2005.00410.xGoogle Scholar
Hurt, E. A., Arnold, L. E., & Lofthouse, N. (2011). Dietary and nutritional treatments for attention-deficit/hyperactivity disorder: Current research support and recommendations for practitioners. Current Psychiatry Reports, 13, 323–332. doi:10.1007/s11920-011-0217-zCrossRefGoogle ScholarPubMed
Impey, M., & Heun, R. (2012). Completed suicide, ideation and attempt in attention deficit hyperactivity disorder. Acta Psychiatrica Scandanavia, 125, 93–102. doi:10.1111/j.1600-0447.2011.01798.xGoogle Scholar
Jester, J. M., Nigg, J. T., Adams, K., Fitzgerald, H. E., Puttler, L. I., Wong, M. M., et al. (2005). Inattention/hyperactivity and aggression from early childhood to adolescence: Heterogeneity of trajectories and differential influence of family environment characteristics. Development and Psychopathology, 17, 99–125.CrossRefGoogle ScholarPubMed
Johnstone, T., van Reekum, C. M., Urry, H. L., Kalin, N. H., & Davidson, R. J. (2007). Failure to regulate: Counterproductive recruitment of top-down prefrontal-subcortical circuitry in major depression. Journal of Neuroscience, 27, 8877–8884. doi:10.1523/jneurosci.2063-07.2007Google Scholar
Kahneman, D. (2011). Thinking, fast and slow (1st ed.). New York: Farrar, Straus and Giroux.Google Scholar
Karalunas, S. L., Huang-Pollock, C. L., & Nigg, J. T. (2012). Decomposing attention-deficit/hyperactivity disorder (ADHD)-related effects in response speed and variability. Neuropsychology, 26, 684–694. doi:10.1037/a00299362012-28978-001Google Scholar
Karg, K., Burmeister, M., Shedden, K., & Sen, S. (2011). The serotonin transporter promoter variant (5-HTTLPR), stress, and depression meta-analysis revisited: Evidence of genetic moderation. Archives of General Psychiatry, 68, 444–454. doi:10.1001/archgenpsychiatry.2010.189Google Scholar
Kavale, K. A., & Forness, S. R. (1983). Hyperactivity and diet treatment: A meta-analysis of the Feingold hypothesis. Journal of Learning Disabilities, 16, 324–330.Google Scholar
Kern, M. L., & Friedman, H. S. (2008). Do conscientious individuals live longer? Health Psychology, 27, 505–512.Google Scholar
Kessler, R. C., Adler, L., Barkley, R., Biederman, J., Conners, C. K., Demler, O., et al. (2006). The prevalence and correlates of adult ADHD in the United States: Results from the Natonal Comorbidity Survey Replication. American Journal of Psychiatry, 163, 716–723.CrossRefGoogle Scholar
Keverne, E. B. (2011). Epigenetics and brain evolution. Epigenomics, 3, 183–191. doi:10.2217/epi.11.10Google Scholar
Kollins, S. H., Anastopoulos, A. D., Lachiewicz, A. M., FitzGerald, D., Morrissey-Kane, E., Garrett, M. E., et al. (2008). SNPs in dopamine D2 receptor gene (DRD2) and norepinephrine transporter gene (NET) are associated with continuous performance task (CPT) phenotypes in ADHD children and their families. American Journal of Medical Genetics, 147B, 1580–1588. doi:10.1002/ajmg.b.30876Google Scholar
Konrad, A., Dielentheis, T. F., El Masri, D., Bayerl, M., Fehr, C., Gesierich, T., et al. (2010). Disturbed structural connectivity is related to inattention and impulsivity in adult attention deficit hyperactivity disorder. European Journal of Neuroscience, 31, 912–919. doi:10.1111/j.1460-9568.2010.07110.xCrossRefGoogle ScholarPubMed
Konrad, A., & Eickhoff, S. B. (2010). Is the ADHD brain wired differently? A review on structural and functional connectivity in attention deficit hyperactivity disorder. Human Brain Mapping, 31, 904–916. doi:10.1002/hbm.21058Google Scholar
Kubota, T., Miyake, K., & Hirasawa, T. (2012). Epigenetic understanding of gene–environment interactions in psychiatric disorders: A new concept of clinical genetics. Clinical Epigenetics, 4, 1. doi:10.1186/1868-7083-4-1Google Scholar
Lasky-Su, J., Anney, R. J., Neale, B. M., Franke, B., Zhou, K., Maller, J. B., et al. (2008). Genome-wide association scan of the time to onset of attention deficit hyperactivity disorder. American Journal of Medical Genetics, 147B, 1355–1358. doi:10.1002/ajmg.b.30869Google Scholar
Leibenluft, E. (2011). Severe mood dysregulation, irritability, and the diagnostic boundaries of bipolar disorder in youths. American Journal of Psychiatry, 168, 129–142. doi:10.1176/appi.ajp.2010.10050766CrossRefGoogle ScholarPubMed
Linnet, K. M., Dalsgaard, S., Obel, C., Wisborg, K., Henriksen, T. B., Rodriguez, A., et al. (2003). Maternal lifestyle factors in pregnancy risk of attention deficit hyperactivity disorder and associated behaviors: Review of the current evidence. American Journal of Psychiatry, 160, 1028–1040.CrossRefGoogle ScholarPubMed
Loo, S. K., & Makeig, S. (2012). Clinical utility of EEG in attention-deficit/hyperactivity disorder: A research update. Neurotherapeutics, 9, 569–587. doi:10.1007/s13311-012-0131-zGoogle Scholar
Luman, M., Oosterlaan, J., & Sergeant, J. A. (2005). The impact of reinforcement contingencies on AD/HD: A review and theoretical appraisal. Clinical Psychology Review, 25, 183–213. doi:10.1016/j.cpr.2004.11.001Google Scholar
Mann, E. M., Ikeda, Y., Mueller, C. W., Takahashi, A., Tao, K. T., Humris, E., et al. (1992). Cross-cultural differences in rating hyperactive-disruptive behaviors in children. American Journal of Psychiatry, 149, 1539–1542.Google Scholar
Martel, M. M., Nigg, J. T., & Lucas, R. E. (2008). Trait mechanisms in youth with and without attention-deficit/hyperactivity disorder. Journal of Research in Personality, 42, 895–913. doi:10.1016/j.jrp.2007.12.004CrossRefGoogle ScholarPubMed
Martel, M. M., Nigg, J. T., & von Eye, A. (2009). How do trait dimensions map onto ADHD symptom domains? Journal of Abnormal Child Psychology, 37, 337–348. doi:10.1007/s10802-008-9255-3CrossRefGoogle ScholarPubMed
Melby-Lervag, M., & Hulme, C. (2012). Is working memory training effective? A meta-analytic review. Developmental Psychology. Advance online publication. doi:10.1037/a0028228Google Scholar
Merrill, R. M., Lyon, J. L., Baker, R. K., & Gren, L. H. (2009). Attention deficit hyperactivity disorder and increased risk of injury. Advances in Medical Science, 54, 20–26. doi:10.2478/v10039-009-0022-7Google Scholar
Mill, J., & Petronis, A. (2008). Pre- and peri-natal environmental risks for attention-deficit hyperactivity disorder (ADHD): The potential role of epigenetic processes in mediating susceptibility. Journal of Child Psychology and Psychiatry, 49, 1020–1030. doi:10.1111/j.1469-7610.2008.01909.xGoogle Scholar
Miller, T. W., Nigg, J. T., & Miller, R. L. (2009). Attention deficit hyperactivity disorder in African American children: What can be concluded from the past ten years? Clinical Psychology Review, 29, 77–86. doi:10.1016/j.cpr.2008.10.001Google Scholar
Moffitt, T. E., Arseneault, L., Belsky, D., Dickson, N., Hancox, R. J., Harrington, H., et al. (2011). A gradient of childhood self-control predicts health, wealth, and public safety. Proceedings of the National Academy of Sciences, 108, 2693–2698.Google Scholar
Molina, B. S., Hinshaw, S. P., Swanson, J. M., Arnold, L. E., Vitiello, B., Jensen, P. S., et al. (2009). The MTA at 8 years: Prospective follow-up of children treated for combined-type ADHD in a multisite study. Journal of the American Academy of Child & Adolescent Psychiatry, 48, 484–500. doi:10.1097/CHI.0b013e31819c23d0S0890-8567(09)60066-6CrossRefGoogle Scholar
Moriyama, T. S., Polanczyk, G., Caye, A., Banaschewski, T., Brandeis, D., & Rohde, L. A. (2012). Evidence-based information on the clinical use of neurofeedback for ADHD. Neurotherapeutics, 9, 588–598. doi:10.1007/s13311-012-0136-7Google Scholar
Nagel, B. J., Bathula, D., Herting, M., Schmitt, C., Kroenke, C. D., Fair, D., et al. (2011). Altered white matter microstructure in children with attention-deficit/hyperactivity disorder. Journal of the American Academy of Child & Adolescent Psychiatry, 50, 283–292. doi:10.1016/j.jaac.2010.12.003CrossRefGoogle ScholarPubMed
Nigg, J. T. (2000). On inhibition/disinhibition in developmental psychopathology: Views from cognitive and personality psychology and a working inhibition taxonomy. Psychological Bulletin, 126, 220–246.Google Scholar
Nigg, J. T. (2006). Temperament and developmental psychopathology. Journal of Child Psychology and Psychiatry, 47, 395–422. doi:10.1111/j.1469-7610.2006.01612.xGoogle Scholar
Nigg, J. T. (2012). Attention-deficit/hyperactivity disorder and adverse health outcomes. Clinical Psychology Review, 33, 215–228.Google Scholar
Nigg, J. T., & Casey, B. J. (2005). An integrative theory of attention-deficit/ hyperactivity disorder based on the cognitive and affective neurosciences. Developmental Psychopathology, 17, 785–806. doi:10.1017/S0954579405050376Google Scholar
Nigg, J. T., John, O. P., Blaskey, L. G., Huang-Pollock, C. L., Willcutt, E. G., Hinshaw, S. P., et al. (2002). Big Five dimensions and ADHD symptoms: Links between personality traits and clinical symptoms. Journal of Personality and Social Psychology, 83, 451–469.CrossRefGoogle ScholarPubMed
Nigg, J. T., Knottnerus, G. M., Martel, M. M., Nikolas, M., Cavanagh, K., Karmaus, W., et al. (2008). Low blood lead levels associated with clinically diagnosed attention-deficit/hyperactivity disorder and mediated by weak cognitive control. Biological Psychiatry, 63, 325–331.Google Scholar
Nigg, J .T., Lewis, K., Edinger, T., & Falk, M. (2012). Meta-analysis of attention-deficit/hyperactivity disorder or attention-deficit/hyperactivity disorder symptoms, restriction diet, and synthetic food color additives. Journal of the American Academy of Child & Adolescent Psychiatry, 51, 86–97. doi:10.1016/j.jaac.2011.10.015Google Scholar
Nigg, J. T., Nikolas, M., & Burt, S. A. (2010). Measured gene-by-environment interaction in relation to attention-deficit/hyperactivity disorder. Journal of the American Academy of Child & Adolescent Psychiatry, 49, 863–873. doi:10.1016/j.jaac.2010.01.025Google Scholar
Nigg, J. T., Nikolas, M., Friderici, K., Park, L., & Zucker, R. A. (2007). Genotype and neuropsychological response inhibition as resilience promoters for attention-deficit/hyperactivity disorder, oppositional defiant disorder, and conduct disorder under conditions of psychosocial adversity. Development and Psychopathology, 19, 767–786. doi:10.1017/S0954579407000387Google Scholar
Nigg, J. T., Willcutt, E. G., Doyle, A. E., & Sonuga-Barke, E. J. (2005). Causal heterogeneity in attention-deficit/hyperactivity disorder: Do we need neuropsychologically impaired subtypes? Biological Psychiatry, 57, 1224–1230. doi:10.1016/j.biopsych.2004.08.025Google Scholar
Nikolas, M. A., & Burt, S. A. (2010). Genetic and environmental influences on ADHD symptom dimensions of inattention and hyperactivity: A meta-analysis. Journal of Abnormal Psychology, 119, 1–17. doi:10.1037/a0018010Google Scholar
Nolen-Hoeksema, S., & Watkins, E. (2011). A heuristic for developing transdiagnostic models of psychopathology: Explaining multifinality and divergent trajectories. Perspectives in Psychological Science, 6, 589–609.Google Scholar
Pastor, P. N., & Reuben, C. A. (2006). Identified attention-deficit/hyperactivity disorder and medically attended, nonfatal injuries: US school-age children, 1997–2002. Ambulatory Pediatrics, 6, 38–44. doi:10.1016/j.ambp.2005.07.002Google Scholar
Poelmans, G., Pauls, D. L., Buitelaar, J. K., & Franke, B. (2011). Integrated genome-wide association study findings: Identification of a neurodevelopmental network for attention deficit hyperactivity disorder. American Journal of Psychiatry, 168, 365–377. doi:10.1176/appi.ajp.2010.10070948CrossRefGoogle Scholar
Polanczyk, G., de Lima, M. S., Horta, B. L., Biederman, J., & Rohde, L. A. (2007). The worldwide prevalence of ADHD: A systematic review and metaregression analysis. American Journal of Psychiatry, 164, 942–948. doi:10.1176/appi.ajp.164.6.942Google Scholar
Purcell, S., & Sham, P. (2002). Variance components models for gene–environment interaction in quantitative trait locus linkage analysis. Twin Research, 5, 572–576. doi:10.1375/136905202762342035Google Scholar
Reid, R., DuPaul, G. J., Power, T. J., Anastopoulos, A. D., Rogers-Adkinson, D., Noll, M. B., et al. (1998). Assessing culturally different students for attention deficit hyperactivity disorder using behavior rating scales. Journal of Abnormal Child Psychology, 26, 187–198.Google Scholar
Riccio, A. (2010). Dynamic epigenetic regulation in neurons: Enzymes, stimuli and signaling pathways. Nature Neuroscience, 13, 1330–1337. doi:10.1038/nn.2671Google Scholar
Rush, B. (1962). Medical inquiries and observations upon the diseases of the mind. New York: Macmillan–Hafner Press. (Original work published 1812)Google Scholar
Rutledge, K. J., van den Bos, W., McClure, S. M., & Schweitzer, J. B. (2012). Training cognition in ADHD: Current findings, borrowed concepts, and future directions. Neurotherapeutics, 9, 542–558. doi:10.1007/s13311-012-0134-9Google Scholar
Rutter, M., Moffitt, T. E., & Caspi, A. (2006). Gene–environment interplay and psychopathology: Multiple varieties but real effects. Journal of Child Psychology and Psychiatry, 47, 226–261. doi:10.1111/j.1469-7610.2005.01557.xGoogle Scholar
Sagiv, S. K., Thurston, S. W., Bellinger, D. C., Tolbert, P. E., Altshul, L. M., & Korrick, S. A. (2010). Prenatal organochlorine exposure and behaviors associated with attention deficit hyperactivity disorder in school-aged children. American Journal of Epidemiology, 171, 593–601. doi:10.1093/aje/kwp427Google Scholar
Sandman, C. A., Davis, E. P., Buss, C., & Glynn, L. M. (2011). Prenatal programming of human neurological function. International Journal of Peptides, 2011, 837596. doi:10.1155/2011/837596Google Scholar
Sanislow, C. A., Pine, D. S., Quinn, K. J., Kozak, M. J., Garvey, M. A., Heinssen, R. K., et al. (2010). Developing constructs for psychopathology research: Research domain criteria. Journal of Abnormal Psychology, 119, 631–639. doi:10.1037/a0020909Google Scholar
Schab, D. W., & Trinh, N. H. (2004). Do artificial food colors promote hyperactivity in children with hyperactive syndromes? A meta-analysis of double-blind placebo-controlled trials. Journal of Developmental and Behavioral Pediatrics, 25, 423–434.Google Scholar
Shackman, A. J., Salomons, T. V., Slagter, H. A., Fox, A. S., Winter, J. J., & Davidson, R. J. (2011). The integration of negative affect, pain and cognitive control in the cingulate cortex. Nature Reviews Neuroscience, 12, 154–167. doi:10.1038/nrn2994nrn2994Google Scholar
Shaw, P., Lerch, J., Greenstein, D., Sharp, W., Clasen, L., Evans, A., et al. (2006). Longitudinal mapping of cortical thickness and clinical outcome in children and adolescents with attention-deficit/hyperactivity disorder. Archives of General Psychiatry, 63, 540–549. doi:10.1001/archpsyc.63.5.540Google Scholar
Smeester, L., Rager, J. E., Bailey, K. A., Guan, X., Smith, N., Garcia-Vargas, G., et al. (2011). Epigenetic changes in individuals with arsenicosis. Chemical Research in Toxicology, 24, 165–167. doi:10.1021/tx1004419Google Scholar
Stevens, L. J., Kuczek, T., Burgess, J. R., Hurt, E., & Arnold, L. E. (2011). Dietary sensitivities and ADHD symptoms: Thirty-five years of research. Clinical Pediatrics (Phila), 50, 279–293. doi:10.1177/0009922810384728Google Scholar
Stevenson, J., Sonuga-Barke, E., McCann, D., Grimshaw, K., Parker, K. M., Rose-Zerilli, M. J., et al. (2010). The role of histamine degradation gene polymorphisms in moderating the effects of food additives on children's ADHD symptoms. American Journal of Psychiatry, 167, 1108–1115. doi:10.1176/appi.ajp.2010.09101529Google Scholar
Sullivan, E. L., Grayson, B., Takahashi, D., Robertson, N., Maier, A., Bethea, C. L., et al. (2010). Chronic consumption of a high-fat diet during pregnancy causes perturbations in the serotonergic system and increased anxiety-like behavior in nonhuman primate offspring. Journal of Neuroscience, 30, 3826–3830. doi:10.1523/jneurosci.5560-09.2010CrossRefGoogle ScholarPubMed
Sullivan, E. L., Nousen, L., & Chamlou, K. (2012). Maternal high fat diet consumption during the perinatal period programs offspring behavior. Physiology & Behavior. Advance online publication. doi:10.1016/j.physbeh.2012.07.014Google Scholar
Swanson, J. M., Entringer, S., Buss, C., & Wadhwa, P. D. (2009). Developmental origins of health and disease: Environmental exposures. Seminars in Reproductive Medicine, 27, 391–402. doi:10.1055/s-0029-1237427Google Scholar
Taylor, E. (2011). Antecedents of ADHD: A historical account of diagnostic concepts. Attention Deficit and Hyperactivity Disorders, 3, 69–75. doi:10.1007/s12402-010-0051-xGoogle Scholar
Thapar, A., Rice, F., Hay, D., Boivin, J., Langley, K., van den Bree, M., et al. (2009). Prenatal smoking might not cause attention-deficit/hyperactivity disorder: Evidence from a novel design. Biological Psychiatry, 66, 722–727. doi:10.1016/j.biopsych.2009.05.032Google Scholar
Toplak, M. E., Rucklidge, J. J., Hetherington, R., John, S. C., & Tannock, R. (2003). Time perception deficits in attention-deficit/ hyperactivity disorder and comorbid reading difficulties in child and adolescent samples. Journal of Child Psychology and Psychiatry, 44, 888–903.Google Scholar
Uddin, L. Q., Kelly, A. M., Biswal, B. B., Margulies, D. S., Shehzad, Z., Shaw, D., et al. (2008). Network homogeneity reveals decreased integrity of default-mode network in ADHD. Journal of Neuroscience Methods, 169, 249–254. doi:10.1016/j.jneumeth.2007.11.031CrossRefGoogle ScholarPubMed
Van den Bergh, B. R. (2011). Developmental programming of early brain and behaviour development and mental health: A conceptual framework. Developmental Medicine and Child Neurology, 53(Suppl. 4), 19–23. doi:10.1111/j.1469-8749.2011.04057.xGoogle Scholar
van Ewijk, H., Heslenfeld, D. J., Zwiers, M. P., Buitelaar, J. K., & Oosterlaan, J. (2012). Diffusion tensor imaging in attention deficit/hyperactivity disorder: A systematic review and meta-analysis. Neuroscience & Biobehavioral Reviews, 36, 1093–1106. doi:10.1016/j.neubiorev.2012.01.003Google Scholar
Volkow, N. D., Wang, G. J., Newcorn, J. H., Kollins, S. H., Wigal, T. L., Telang, F., et al. (2011). Motivation deficit in ADHD is associated with dysfunction of the dopamine reward pathway. Molecular Psychiatry, 16, 1147–1154. doi:10.1038/mp.2010.97mp201097Google Scholar
Whiteside, S. P., & Lynam, D. R. (2003). Understanding the role of impulsivity and externalizing psychopathology in alcohol abuse: Application of the UPPS impulsive behavior scale. Experimental and Clinical Psychopharmacology, 11, 210–217.Google Scholar
Willcutt, E. G., Doyle, A. E., Nigg, J. T., Faraone, S. V., & Pennington, B. F. (2005). Validity of the executive function theory of attention-deficit/hyperactivity disorder: A meta-analytic review. Biological Psychiatry, 57, 1336–1346. doi:10.1016/j.biopsych.2005.02.006Google Scholar
Willcutt, E. G., Nigg, J. T., Pennington, B. F., Solanto, M. V., Rohde, L. A., Tannock, R., et al. (2012). Validity of DSM-IV attention deficit/hyperactivity disorder symptom dimensions and subtypes. Journal of Abnormal Psychology, 121, 991–1010. doi:10.1037/a00273472012-12944-001Google Scholar
Willcutt, E. G., Sonuga-Barke, E., Nigg, J. T., & Sergeant, J. A. (Eds.). (2008). Neuropsychology of childhood disorders (Vol. 24). Basel: Karger.Google Scholar
Xu, X., Nembhard, W. N., Kan, H., Kearney, G., Zhang, Z. J., & Talbott, E. O. (2011). Urinary trichlorophenol levels and increased risk of attention deficit hyperactivity disorder among US school-aged children. Occupational and Environmental Medicine, 68, 557–561. doi:10.1136/oem.2010.063859Google Scholar