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Individual differences in sensitivity to the early environment as a function of amygdala and hippocampus volumes: An exploratory analysis in 12-year-old boys

Published online by Cambridge University Press:  21 December 2020

Michael Pluess Open the ORCID record for Michael Pluess [Opens in a new window] ,
Stephane A. De Brito ,
Alice Jones Bartoli ,
Eamon McCrory  and
Essi Viding
Michael Pluess*
Affiliation:
Department of Biological and Experimental Psychology, Queen Mary University of London, London, UK
Stephane A. De Brito
Affiliation:
School of Psychology, University of Birmingham, Edgbaston, UK
Alice Jones Bartoli
Affiliation:
Department of Psychology, Goldsmiths University of London, London, UK
Eamon McCrory
Affiliation:
Psychology and Language Sciences, University College London, London, UK
Essi Viding
Affiliation:
Psychology and Language Sciences, University College London, London, UK
*
Author for Correspondence: Michael Pluess, Department of Biological and Experimental Psychology, Queen Mary University of London, Mile End Road, LondonE1 4NS, UK; E-mail: m.pluess@qmul.ac.uk
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Abstract

Children differ in their response to environmental exposures, with some being more sensitive to contextual factors than others. According to theory, such variability is the result of individual differences in neurobiological sensitivity to environmental features, with some individuals generally more affected by both negative and/or positive experiences. In this exploratory study we tested whether left and right amygdala and hippocampus volumes (corrected for total brain size) account for individual differences in response to environmental influences in a sample of 62 boys. Cumulative general environmental quality, ranging from low to high, was measured across the first 9 years and child behavior was reported by teachers when boys were 12–13 years old. According to analyses, only the left amygdala volume – not any of the other brain volumes – emerged as an important brain region for sensitivity to positive environmental aspects. Boys with a larger left amygdala benefited significantly more from higher environmental quality than boys with a smaller left amygdala whilst not being more vulnerable to lower quality. Besides providing preliminary evidence for differences in environmental sensitivity due to brain structure, the results also point to the left amygdala as having a specific role regarding the response to environmental influences.

Keywords

amygdaladifferential susceptibilityenvironmental sensitivityhippocampusvantage sensitivity
Type
Regular Article
Information
Development and Psychopathology , Volume 34 , Issue 3 , August 2022 , pp. 901 - 910
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Copyright
© The Author(s), 2020. Published by Cambridge University Press

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