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A Model of the Signal Transduction Process under a Delay

Part of: Stability theory

Published online by Cambridge University Press:  31 January 2018

Jutarat Kongson  and
Somkid Amornsamankul
Jutarat Kongson*
Affiliation:
Department of Mathematics, Burapha University, Chonburi 20130, Thailand Centre of Excellence in Mathematics, Bangkok 10400, Thailand
Somkid Amornsamankul
Affiliation:
Department of Mathematics, Mahidol University, Bangkok 10400, Thailand Centre of Excellence in Mathematics, Bangkok 10400, Thailand
*
*Corresponding author. Email address:jutarat.kongson@gmail.com (J. Kongson)
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Abstract

The signal transduction pathway is the important process of communication of the cells. It is the dynamical interaction between the ligand-receptor complexes and an inhibitor protein in second messenger synthesis. The signaling molecules are detected and bounded by receptors, typically G-Protein receptors, across the cell membrane and that in turns alerts intracellular molecules to stimulate a response or a desired consequence in the target cells. In this research, we consider a model of the signal transduction process consisting of a system of three differential equations which involve the dynamic interaction between an inhibitor protein and the ligand-receptor complexes in the second messenger synthesis. We will incorporate a delay τ in the time needed before the signal amplification process can take effect on the production of the ligand-receptor complex. We investigate persistence and stability of the system. It is shown that the system allows positive solutions and the positive equilibrium is locally asymptotically stable under suitable conditions on the system parameters.

Keywords

Signal transduction pathwaylocally asymptotically stablepersistenceligand-receptordelay

MSC classification

Secondary: 34D05: Asymptotic properties 34D20: Stability
Type
Research Article
Information
East Asian Journal on Applied Mathematics , Volume 7 , Issue 4 , November 2017 , pp. 741 - 751
Copyright
Copyright © Global-Science Press 2017 

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