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Published online by Cambridge University Press: 20 October 2005
Measles has been known as a highly contagious serious infection in man for centuries. After a prodromal fever, patients often experience coryza, cough and conjunctivitis followed by a blotchy rash. The disease is more severe in infants and adults with death resulting from encephalitis or pneumonia. Malnourished and immunosuppressed people are also more prone to serious complications and death. Subacute sclerosing panencephalitis (SSPE) is a rare complication, occurring as late sequela several years after measles infection at a rate of 1–5 per million cases.