Hostname: page-component-745bb68f8f-lrblm Total loading time: 0 Render date: 2025-01-13T02:24:59.203Z Has data issue: false hasContentIssue false
  • English
  • Français

An M-associated protein antigen (MAP) of group A streptococci

Published online by Cambridge University Press:  15 May 2009

Jean P. Widdowson ,
W. R. Maxted  and
Alison M. Pinney
Jean P. Widdowson
Affiliation:
Cross-Infection Reference Laboratory, Central Public Health Laboratory, Colindale Avenue, London, NW 9 5HT
W. R. Maxted
Affiliation:
Cross-Infection Reference Laboratory, Central Public Health Laboratory, Colindale Avenue, London, NW 9 5HT
Alison M. Pinney
Affiliation:
Cross-Infection Reference Laboratory, Central Public Health Laboratory, Colindale Avenue, London, NW 9 5HT
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

A streptococcal antigen that is closely associated with the M-antigen, but is not type specific can be detected by means of a complement-fixation test in extracts of M-positive, but not of M-negative, variants of group A streptococci. Purification of acid extracts results in a concomitant increase in the purity both of the type-specific M-antigen and of the M-associated protein (MAP). Antibody to MAP is present in the sera of patients who have had streptococcal infection. The highest titres are found in patients with rheumatic fever.

Type
Research Article
Information
Journal of Hygiene , Volume 69 , Issue 4 , December 1971 , pp. 553 - 564
Copyright
Copyright © Cambridge University Press 1971

References

REFERENCES

Anthony, B. F. (1970). Quantitative and qualitative studies of antibody to streptoeoecal M-protein. Journal of Immunology 105, 379–88.CrossRefGoogle ScholarPubMed
Anthony, B. F., Perlman, L. V. & Wannamaker, L. W. (1967). Skin infections and acute nephritis in American Indian children. Pediatrics 39, 263–79.CrossRefGoogle ScholarPubMed
Beachey, E. H., Alberti, H. & Stollerman, G. H. (1969). Delayed hypersensitivity to purified streptoeoecal M-protein in guinea pigs and in man. Journal of Immunology 102, 42–52.CrossRefGoogle ScholarPubMed
Bradstreet, C. M. P. & Taylor, C. E. D. (1962). Technique of complement fixation test pplicable to the diagnosis of virus diseases. Monthly Bulletin of the Ministry of Health and the Public Health Laboratory Service 21, 96–104.Google Scholar
Cruickshank, R. (1965). Editor. Medical Microbiology, page 742, 11th edition. Edinburgh and London: E. and S. Livingstone Ltd.Google Scholar
Dillon, H. C. & Reeves, M. S. (1969). Streptoeoecal antibody titres in skin infection and acute glomerulonephritis. Pediatrics Research 3, 362.Google Scholar
Elliott, S. D. (1945). A proteolytic enzyme produced by group A streptococci with special reference to its effect on the type specific M-antigen. Journal of Experimental Medicine 81, 573–91.CrossRefGoogle Scholar
Erwa, H. H. (1968). Detection of antibodies to cellular antigens of Streptococcus pyogenes. Ph.D. Thesis, University of London.Google Scholar
Fox, E. N. & Wittner, M. K. (1965). The multiple molecular structure of the M-proteins of group A streptococci. Proceedings of the National Academy of Sciences 54, 1118–25.CrossRefGoogle ScholarPubMed
Freimer, E. H. (1966). The protoplast membrane of group A streptococcus. Current Research on Group A Streptococcus, pp. 54–67. Editor Caravano, R.. Amsterdam: Excerpta Medica Foundation.Google Scholar
Fuller, A. T. (1938). The formamide method for the extraction of polysaccharides from haemolytic streptococci. British Journal of Experimental Pathology 19, 130–9.Google Scholar
Gooder, H. & Williams, R. E. O. (1959). Titration of anti-streptolysin O. The Association of Clinical Pathologists, Broadsheet No. 25 (New series).Google Scholar
Johnson, R. H. & Vosti, K. L. (1968). Purification of two fragments of M-protein from a strain of group A type 12 streptococcus. Journal of Immunology 101, 381–91.CrossRefGoogle Scholar
Kaplan, E. L., Anthony, B. F., Chapman, S. S., Ayoub, E. M. & Wannamaker, L. W. (1970). The influence of site of infection on the immune response to group A streptococci. Journal of Clinical Investigation 49, 1405–14.CrossRefGoogle ScholarPubMed
Kaplan, M. H. (1966). Multiple nature of the cross-reactive relationship between antigens of group A streptococcus and mammalian tissue. Current Research on Group A Streptococcus, pp. 139–44. Editor Caravano, R.. Amsterdam: Excerpta Medica Foundation.Google Scholar
Kaplan, M. H. (1969). Cross-reactions of group A streptococci and heart tissue: varying serologic specificity of cross-reactive antisera and relation to carrier-hapten specificity. Transplantation Proceedings 1 (4), 976–80.Google Scholar
Lancefield, R. C. (1928). The antigenic complex of Streptococcus hemolyticus. 1. Demonstration of a type specific substance in extracts of Streptococcus hemolyticus. Journal of Experimental Medicine 47, 91–103.CrossRefGoogle Scholar
Lancefield, R. C. & Perlmann, G. E. (1952). Preparation and properties of type-specific M-antigen isolated from a group A type 1 hemolytic streptococcus. Journal of Experimental Medicine 96, 71–82.CrossRefGoogle Scholar
Lowry, O. H., Rosebrough, N. J., Farr, A. L. & Randall, R. J. (1951). Protein measurement with the Folin phenol reagent. Journal of Biological Chemistry 193, 265–75.CrossRefGoogle ScholarPubMed
Maxted, W. R. & Potter, E. V. (1967). The presence of type 12 M-protein in group G streptococci. Journal of General Microbiology 49, 119–25.CrossRefGoogle ScholarPubMed
Maxted, W. R. & Valkenburg, H. A. (1969). Variation in the M-antigen of group A streptococci. Journal of Medical Microbiology 2, 199–210.CrossRefGoogle ScholarPubMed
Nelson, J., Ayoub, E. M. & Wannamaker, L. W. (1968). Streptococcal antidesoxyribonuclease B: Microtechnique determination. Journal of Laboratory and Clinical Medicine 71, 867–73.Google ScholarPubMed
Potter, E. V., Seigal, A. C., Simon, N. M., McAninch, J., Earle, D. P., Poon-King, T., Mohammed, I. & Abidh, S. (1968). Streptococcal infections and epidemic acute glomerulonephritis in Trinidad. Journal of Pediatrics 72, 871–84.CrossRefGoogle ScholarPubMed
Saito, Y. (1970). Biological activity of papain digested Streptococcal anti-M antibody. Japanese Journal of Microbiology 13, 19–28.CrossRefGoogle Scholar
Stollerman, G. H., Alberti, H. & Plemmons, J. A. (1967). Opsonization of group A streptococci by complement deficient blood from a patient with hereditary angioneurotic edema. Journal of Immunology 99, 92–7.CrossRefGoogle Scholar
Stollerman, G. H., Rytel, M. & Ortiz, J. (1963). Accessory plasma factors involved in the bactericidal test for type-specific antibody to group A streptococci. II. Human plasma cofaetor(s) enhancing Opsonization of encapsulated organisms. Journal of Experimental Medicine 117, 1–17.CrossRefGoogle Scholar
Todd, E. W. (1927). The influence of sera obtained from cases of Streptococcal septicaemia on the virulence of homologous cocci. British Journal of Experimental Pathology 8, 361–8.Google Scholar
Widdowson, J. P., Maxted, W. R. & Grant, D. L. (1970). The production of opacity in serum by group A streptococci and its relationship with the presence of M-antigen. Journal of General Microbiology 61, 343–53.CrossRefGoogle Scholar
Widdowson, J. P., Maxted, W. R., Grant, D. L. & Pinney, A. M. (1971). The relationship between M-antigen and opacity factor in group A streptococci. Journal of General Microbiology 65, 69–80.CrossRefGoogle ScholarPubMed
Zabriskie, J. B. (1969). The relationship of Streptococcal cross-reactive antigens to rheumatic fever. Transplantation Proceedings 1, 968–75.Google ScholarPubMed
Zabriskie, J. B. & Freimer, E. H. (1966). An immunological relationship between the group A streptococcus and mammalian muscle. Journal of Experimental Medicine 124, 661–78.CrossRefGoogle Scholar
Zabriskie, J. B., Hsu, K. C. & Seegal, B. C. (1970). Heart-reactive antibody associated with rheumatic fever. Characterization and diagnostic significance. Clinical and Experimental Immunology 7, 147–59.Google ScholarPubMed