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Antigenicity of T.A.B.C. vaccine after admixture with tetanus toxoid for various periods

Published online by Cambridge University Press:  15 May 2009

F. G. Hitch ,
L. S. Ashcroft  and
C. A. Green
F. G. Hitch
Affiliation:
From the Royal Naval Medical School
L. S. Ashcroft
Affiliation:
From the Royal Naval Medical School
C. A. Green
Affiliation:
From the Royal Naval Medical School
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1. The antigenicity of batches of T.A.B.C. vaccine after mixture with tetanus toxoid and held at 18–25° C. for 6–7 weeks, 12–13 months and 16 months was tested in groups of adult males in whom the pre-inoculation titres for the various antigens were strictly comparable.

2. The batch used within 6–7 weeks of production produced the greatest effect, but the older batches were not greatly reduced in potency.

3. Within the limitations imposed by the restricted investigation, the more effective result following the use of the 16 months vaccine as compared with the 12–13 months vaccine indicates that factors in addition to that of time were concerned in the deterioration of antigenic power.

We are indebted to the Medical Officers in charge of the Training Establishments concerned, Surgeon Captain H. F. Briggs, M.B., Ch.B, F.R.C.S. (Ed.), R.N., Surgeon Captain W. P. Vicary, M.R.C.S., L.R.C.P., R.N., and Surgeon Commander H. A. Shellwell, M.R.C.S., L.R.C.P., R.N.V.R., for their ready and valuable co-operation.

Type
Research Article
Information
Journal of Hygiene , Volume 43 , Issue 3 , September 1943 , pp. 207 - 213
Copyright
Copyright © Cambridge University Press 1943

References

REFERENCES

Felix, A., Rainsford, S. G. & Stokes, E. J. (1941). Antibody response and systemic reactions after inoculation of a new type of T.A.B.C. vaccine. Brit. Med. J. 1, 435.CrossRefGoogle ScholarPubMed
Rainsford, S. G. (1942). The preservation of Vi antigen in T.A.B.C. vaccine with a note on combined active immunization with T.A.B.C. vaccine in tetanus formol-toxoid. J. Hyg., Camb., 42, 297.CrossRefGoogle ScholarPubMed