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Antimicrobial susceptibilities and serotyping of Neisseria gonorrhoeae in southern Africa: influence of geographical source of infection

Published online by Cambridge University Press:  19 October 2009

C. A. Ison ,
N. S. Roope ,
Y. Dangor ,
F. Radebe  and
R. Ballard
C. A. Ison
Affiliation:
Department of Medical Microbiology, St Mary's Hospital Medical School, Norfolk Place, Paddington, London W2 1PG
N. S. Roope
Affiliation:
Department of Medical Microbiology, St Mary's Hospital Medical School, Norfolk Place, Paddington, London W2 1PG
Y. Dangor
Affiliation:
Emergent Pathogen Research Unit of the South African Medical Research Council, School of Pathology, University of Witwatersrand and South African Institute of Medical Research, Johannesburg, South Africa
F. Radebe
Affiliation:
Emergent Pathogen Research Unit of the South African Medical Research Council, School of Pathology, University of Witwatersrand and South African Institute of Medical Research, Johannesburg, South Africa
R. Ballard
Affiliation:
Emergent Pathogen Research Unit of the South African Medical Research Council, School of Pathology, University of Witwatersrand and South African Institute of Medical Research, Johannesburg, South Africa
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One hundred and ninety-two strains of Neisseria gonorrhoeae isolated from migrant mine-workers were tested for their susceptibility to antibiotics, auxotyped and serotyped. Of the total, 93 (48%) were acquired locally and 64 (33%) from different geographical locations. Plasmid-mediated resistance to penicillin was found in 28 (14·6%) strains and was associated predominantly with the presence of 5·0 kb penicillinase encoding plasmid (18/28, 64%). Chromosomal resistance to penicillin (MIC ≥ 1 mg/l) was detected in 14 (7·3%) strains. Resistance to tetracycline was chromosomally and not plasmid-mediated. Antibiotic resistance was encountered most commonly among strains acquired in Natal. The overall gonococcal population was sensitive to ceftriaxone, ciprofloxacin. spectinomycin and azithromycin. Nine auxotype/serovar (A/S) classes were encountered among penicillinase-producing N. gonorrhoeae (PPNG) compared to 24 A/S classes among non-PPNG strains. The most common A/S class was NR/IA-6 which accounted for 38% of PPNG and 15% of non-PPNG.

Type
Research Article
Information
Epidemiology & Infection , Volume 110 , Issue 2 , April 1993 , pp. 297 - 305
Copyright
Copyright © Cambridge University Press 1993

References

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