Hostname: page-component-cd9895bd7-jkksz Total loading time: 0 Render date: 2024-12-27T10:56:19.116Z Has data issue: false hasContentIssue false
  • English
  • Français

Anti-Streptolysin Titres of Human Sera in Health and in Various Streptococcal Infections

Published online by Cambridge University Press:  15 May 2009

R. D. Stuart
R. D. Stuart
Affiliation:
From the Bacteriology Department, Durham University College of Medicine
Rights & Permissions [Opens in a new window]

Extract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

1. Streptolysin production by twenty-seven strains of haemolytic streptococci grown in a special buffered glucose serum-free broth has been compared and a very marked variation noted.

2. The anti-streptolysin titres in healthy individuals and in others at the commencement of illness showed a pronounced variation.

3. Throat infections with S. haemolyticus usually produced a rise in the level of circulating anti-streptolysin in the patients' blood, and this could be considered diagnostically significant.

4. Throat infections with haemolytic streptococci showed rather more rapid production and higher titres of anti-streptolysin than did skin infections such as erysipelas, and both throat and skin infections were greatly superior to uterine infections in this respect.

5. Neither the level of circulating anti-streptolysin at the commencement of infection nor the rate and height of response could be shown to have any bearing on the severity of the disease, except that a poor anti-streptolysin response was found in certain cases of relapses and toxic complications of throat infections. This appeared, however, to be merely indicative of a general poor antitoxic response and not to have any meaning by itself, except that in certain arthritic cases where the question of its importance was more open. No correlation whatsoever was noted between anti-streptolysin response and relapses and septic complications in erysipelas.

6. In general the anti-streptolysin response in infection appeared to depend more on the individual than on the site or severity of infection.

Type
Research Article
Information
Journal of Hygiene , Volume 36 , Issue 1 , February 1936 , pp. 26 - 36
Copyright
Copyright © Cambridge University Press 1936

References

REFERENCES

Coburn, A. F. and Pauli, Ruth H. (1932). J. Clin. Med. 56, 609.Google Scholar
Myers, W. K. and Keefer, C. S. (1934). J. Clin. Invest. 13, 155.Google Scholar
Todd, E. W. (1932 a). J. Exp. Med. 55, 267.CrossRefGoogle Scholar
Todd, E. W. (1932 b). Brit. J. Exp. Path. 13, 248.Google Scholar
Todd, E. W. and Hewitt, L. F. (1932). J. Path. and Bact. 35, 973.Google Scholar
Wilson, Mary G., Wheeler, G. W. and Leask, , Marguerite, M (1934). Proc. Soc. Exp. Biol. and Med. 31, 1001.CrossRefGoogle Scholar
Wilson, Mary G., Wheeler, G. W. and Leask, , Marguerite, M (1935). J. Clin. Invest. 14, 333.CrossRefGoogle Scholar