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Binding to and antibacterial effect of aztreonam, temocillin, gentamicin and tobramycin on human faeces

Published online by Cambridge University Press:  19 October 2009

M. P. Hazenberg ,
A. M. Pennock-Schröder  and
J. P. van de Merwe
M. P. Hazenberg
Affiliation:
Department of Medical Microbiology, Erasmus University Rotterdam, P.O. Box 1738, 3000 DR Rotterdam, The Netherlands
A. M. Pennock-Schröder
Affiliation:
Department of Medical Microbiology, Erasmus University Rotterdam, P.O. Box 1738, 3000 DR Rotterdam, The Netherlands
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Aztreonam, temocillin, gentamicin and tobramycin were studied for their effect on the human faecal flora in vitro and for their usefulness for selective decontamination (SD) of the gastrointestinal tract. The sensitivities of the obligately anaerobic flora and the Gram-negative facultatively anaerobic bacteria were determined and the ratio was expressed as SD factor. Tho high SD factor of the flora from most subjects for aztreonam and tobramycin indicates that the drugs are useful for SD in contrast to temocillin and gentamicin. Binding to and subsequent release of tobramycin from faeces are presumed to facilitate the maintenance of adequate concentrations in the intestine despite the discontinuous intake.

Type
Research Article
Information
Journal of Hygiene , Volume 95 , Issue 2 , October 1985 , pp. 255 - 263
Copyright
Copyright © Cambridge University Press 1985

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