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The chronic toxicity of p-nitrophenyl diethyl thiophosphate (E. 605): A long-term feeding experiment with rats

Published online by Cambridge University Press:  19 October 2009

J. M. Barnes  and
F. A. Denz
J. M. Barnes
Affiliation:
Medical Research Council Unit for Research in Toxicology, Woodmansterne Road, Carshalton Beeches, Surrey
F. A. Denz
Affiliation:
Medical Research Council Unit for Research in Toxicology, Woodmansterne Road, Carshalton Beeches, Surrey
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1. The results of feeding albino rats on diets containing 100, 75, 50, 20 and 10 parts per million of the insecticide p-nitrophenyl diethyl thiophosphate (E. 605, Parathion) are described. The feeding of 50, 20 and 10 p.p.m. was continued for a year.

2. At 100 and 75 p.p.m. most of the rats died in the first few weeks. At 50 p.p.m. a few deaths resulted from poisoning, and symptoms were seen on and off throughout the year. At 20 and at 10 p.p.m. no evidence of poisoning was found.

3. Histological examination of animals dying with symptoms showed the lesions of the exocrine glands and the hypoplasia of spleen and thymus that have been reported in acute poisoning by E.605. No other lesions attributable to chronic poisoning were found.

4. Breeding experiments were done with animals from all groups. The second generation of rats fed at 10 p.p.m. produced many dead in their litters. No explanation has been found for this observation.

Type
Research Article
Information
Journal of Hygiene , Volume 49 , Issue 4 , December 1951 , pp. 430 - 441
Copyright
Copyright © Cambridge University Press 1951

References

Barnes, M. M., Carman, G. E., Ewart, W. H. & Gunther, F. A. (1950). In Agricultural Control Chemicals, p. 112. Washington: American Chemical Society.CrossRefGoogle Scholar
Carman, G. E., Ewart, W. H., Barnes, M. M. & Gunther, F. A. (1950). In Agricultural Control Chemicals, p. 128. Washington: American Chemical Society.CrossRefGoogle Scholar
Denz, F. A. (1951). J. Path. Bact. 63, 81.CrossRefGoogle Scholar
Dubois, K. P., Doull, J., Salerno, P. R. & Coon, J. M. (1949). J. Pharmacol. 95, 79.Google Scholar
Fitzhugh, O. G. (1948). Industr. Engng Chcm. 40, 704.CrossRefGoogle Scholar
Forssling, S. (1948). Ada Pharm. Toxicol. 4, 143.Google Scholar
Grob, D., Garuck, W. L. & Harvey, A. M. (1950). Johns Hopk. Hosp. Bull. 87, 106.Google Scholar
Hazleton, L. W. & Holland, Emily G. (1950). In Agricultural Control Chemicals, p. 31. Washington: American Chemical Society.CrossRefGoogle Scholar
Jones, H. W. Jr & Landing, B. (1948). Amer. J. Path. 24, 722.Google Scholar
Koppanyi, T. (1948). Johns Hopk. Hosp. Bull. 83, 532.Google Scholar
Lehman, A. J. (1949). Association of Food and Drug Officials of the United States, 13, 65.Google Scholar
Sallé, J. (1950). Arch. int. Pharmacodyn, 82, 181.Google Scholar
Valade, P. (1950). Arch. int. Pharmacodyn 84, 300.Google Scholar
Walker, K. C. (1950). In Agriculhiral Control Chemicals, p. 123. Washington: American Chemical Society.CrossRefGoogle Scholar
Westlake, W. E. & Fahey, J. E. (1950). In Agricultural Control Chemicals, p. 117. Washington: American Chemical Society.CrossRefGoogle Scholar