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Colonization resistance of the digestive tract of mice during systemic antibiotic treatment

Published online by Cambridge University Press:  15 May 2009

D. van der Waaij ,
J. M. Berghuis  and
J. E. C. Lekkerkerk
D. van der Waaij
Affiliation:
Radiobiological Institute TNO, Lange Kleiweg 151, Rijswijk (Z.H.), The Netherlands
J. M. Berghuis
Affiliation:
Radiobiological Institute TNO, Lange Kleiweg 151, Rijswijk (Z.H.), The Netherlands
J. E. C. Lekkerkerk
Affiliation:
Radiobiological Institute TNO, Lange Kleiweg 151, Rijswijk (Z.H.), The Netherlands
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Summary

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During systemic treatment of mice with ampicillin or streptomycin, oral contaminations with exogenous bacterial species resulted in an abnormal colonization pattern. The contaminants persisted much longer and in much higher concentrations in the caecum of systemically treated mice than in control animals. Spread of the contaminant into the mesenteric lymph nodes and the spleen was found much more often in the antibiotic treated group. This, however, was only seen when the contaminant was ‘resistant’ to the antibiotic injected. The experiments suggest that the ‘CR-inducing species’ of the microflora live in close contact with the mucosa and therefore could be identical with the anaerobic tapered rods described by Savage & Dubos (1968).

Type
Research Article
Information
Journal of Hygiene , Volume 70 , Issue 4 , December 1972 , pp. 605 - 610
Copyright
Copyright © Cambridge University Press 1972

References

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