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Comparison of the protective efficacies of the live vaccine RIT 4025 and an inactivated vaccine against a natural heterologous A/Victoria/3/75 infection

Published online by Cambridge University Press:  15 May 2009

A. Delem ,
W. Van Rensburg  and
I. Flaskett
A. Delem
Affiliation:
Immuno-biology Department, Recherche et Industrie Thérapeutiques (RIT), 89 rue de l'institut, B-1330 Rixensart, Belgium
W. Van Rensburg
Affiliation:
Smith Kline & French Laboratories, P.O. Box 38, Isando 1600, Transvaal, South Africa
I. Flaskett
Affiliation:
Smith Kline & French Laboratories, P.O. Box 38, Isando 1600, Transvaal, South Africa
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Summary

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A clinical trial was initiated in South Africa before the winter season of 1976. The study involved 253 volunteers divided into three groups of vaccinees and one control group.

Two groups of vaccinees were inoculated with either one or two doses at 2 weeks' interval (107·2 EID 50/dose) of the RIT 4025 live recombinant strain [A/Scotland/840/74 (H3N2) serotype] and one group received one injection of an inactivated vaccine [A/Port Chalmers/1/73 (H3N2), 360 i.u., A/Scotland/840/74 (H3N2), 300 i.u. and B/Hong Kong/8/73, 300 i.u./dose].

The serum antihaemagglutinin antibody responses against the heterologous A/Victoria/3/75 strain as measured by the single radial haemolysis test were satisfactory and not statistically different in all groups of vaccinees. On the other hand, the antineuraminidase antibody response was better in the group receiving the killed vaccine.

At the end of the influenza season, A/Victoria/3/75 infections were confirmed serologically.

Only 12% of the infections were symptomatic. The infection rate was significantly reduced in the live vaccine groups, whereas in the killed vaccine group the percentage of infection was lower but not significantly different from that in the placebo group.

Type
Research Article
Information
Journal of Hygiene , Volume 83 , Issue 2 , October 1979 , pp. 221 - 229
Copyright
Copyright © Cambridge University Press 1979

References

Aymabd-Henby, M. & Coleman, M. T. (1973). Influenza neuraminidase and neuraminidase inhibition test procedure Bulletin of the World Health Organization 48, 199.Google Scholar
Beabe, A. S., Hobson, D., Reed, S. E. & Tyrrell, D. A. J. (1968). A comparison of live and killed influenza virus vaccines. Lancet ii, 418.Google Scholar
Callow, K. A. & Beare, A. S. (1976). Measurement of antibody to influenza virus neuraminidase by single radial haemolysis in agarose gels. Infection and Immunity 13, 1.CrossRefGoogle ScholarPubMed
Delem, A. & Jovanovic, D. (1978). Correlation between rate of infection and preexisting titer of serum antibody as determined by single radial hemolysis during an epidemic of influenza A/Victoria/3/75. Journal of Infectious Diseases 137, 194.Google Scholar
Florent, G., Lobmann, M., Beare, A. S. & Zygbaich, N. (1977). RNA's of influenza virus recombinants derived from parents of known virulence for man. Archives of Virology 54, 19.CrossRefGoogle Scholar
Freestone, D. S., Hamilton-Smith, S., Schild, G. C., Buokland, R., Chinn, S. & Tyrrell, D. A. J. (1972). Antibody response and resistance to challenge in volunteers vaccinated with live attenuated, detergent split and oil adjuvant A2/Hong Kong/68 (H3N2) influenza vaccines. Journal of Hygiene 70, 531.Google Scholar
Hobson, D., Baker, F. A., Cubry, R. L., Beabe, A. S. & Massey, P. M. O. (1973). The efficacy of live and inactivated vaccine of Hong Kong influenza virus in an industrial community. Journal of Hygiene 71, 641.Google Scholar
Kilbourne, E. D. (1975). In The Influenza Viruses and Influenza, Epidemiology of Influenza, p. 483. Academic Press.Google Scholar
Langmtjir, A. D., Hendebson, D. A. & Serfling, R. E. (1964). The epidemiological basis for the control of influenza. American Journal of Public Health 54, 563.CrossRefGoogle Scholar
Mackenzie, J. S., Mackenzie, I., Lloyd, J. & Dent, V. (1975). Comparative trials of live attenuated and detergent split influenza virus vaccines. Journal of Hygiene 75, 425.CrossRefGoogle ScholarPubMed
Noble, G. R., Corey, L., Rosenberg, R. L., Hoke, Ch., Brown, W. J., Kaye, H. S., Bregman, D. J., Gregg, M. B. & Dowdle, W. R. (1975). An open field trial of live attenuated influenza A/England/42/72 (H3N2) vaccine. II. Illness and infection rates during an epidemic of A/port Chalmers-like influenza. 15th Interscience Conference on Antimicrobial Agents and Chemotherapy,Washington D.C.,September 24–26, abstract no. 111.Google Scholar
Pbestzie, A., Delem, A. & Huygelen, C. (1976). Protective efficacy of a live attenuated influenza virus vaccine ('Alice' strain). Postgraduate Medical Journal 52, 345.Google Scholar
Rubin, R. J., Noble, G. R., Corey, L., Brown, W. S. JR, Brandling-Bennett, D., Kaye, H. S., Coleman, M. T., Gregg, M. B. & Dowdle, W. R. (1976). Live attenuated influenza A/England/42/72 (H3N2) virus vaccine: a field trial. Journal of Infectious Diseases 133, 613.Google Scholar
Schild, G. C., Pereira, M. S. & Chakraverty, P. (1975). Single radial haemolysis – a new method for the assay of antibody to influenza haemagglutinin. Bulletin of the World Health Organization 52, 43.Google Scholar
Stuart-Harris, CH. in, Fox, J. P. & Kilbourne, E. D. (1973). Epidemiology of influenza – Summary of influenza Workshop IV. Journal of Infectious Diseases 128, 361.Google Scholar
Weekly Epidemiological Records (1976). 29, 234.Google Scholar