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Determination of the colonization resistance of the digestive tract of individual mice

Published online by Cambridge University Press:  15 May 2009

D. van der Waaij  and
J. M. Berghuis
D. van der Waaij
Affiliation:
Radiobiological Institute TNO, 151 Lange Kleiweg, Bijswijk (ZH), The Netherlands
J. M. Berghuis
Affiliation:
Radiobiological Institute TNO, 151 Lange Kleiweg, Bijswijk (ZH), The Netherlands
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It has been shown that it is possible to investigate the colonization resistance in individual mice by determining the concentration of a certain contaminant (S.R.-E. coli) in the faeces during the first 4 days after contamination. Experimental contamination is contra-indicated in many cases such as in individuals with decreased resistance to infection. Particularly in this group, the value of the colonization resistance should be determined. It appeared to be possible to determine the colonization resistance in such individuals by quantitative biotyping of the Enterobacteriaceae species in the faeces on several consecutive days.

Type
Research Article
Information
Journal of Hygiene , Volume 72 , Issue 3 , June 1974 , pp. 379 - 387
Copyright
Copyright © Cambridge University Press 1974

References

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