Hostname: page-component-745bb68f8f-mzp66 Total loading time: 0 Render date: 2025-01-07T12:14:37.112Z Has data issue: false hasContentIssue false
  • English
  • Français

The distribution of vaccinia virus, complement-fixing antigen and haemagglutinin throughout the egg after inoculation of the chorio-allantoic membrane

Published online by Cambridge University Press:  15 May 2009

Barbara M. Tobin
Barbara M. Tobin
Affiliation:
Department of Bacteriology, University of Manchester
Rights & Permissions [Opens in a new window]

Extract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Vaccinia virus inoculated on the chorio-allantois and causing infection spread to the uninoculated part of the membrane, the embryo, the allantoic and amniotic fluids and the yolk within 1 day.

The virus grew in the embryo and possibly in the uninoculated part of the chorio-allantois, but in the latter no macroscopic lesions were detected.

Virus increased in amount in the allantoic fluid and may have grown in the lining of the allantoic sac; it did not increase in the amniotic fluid; it was present in yolk and increased slightly but its local growth was doubtful.

The presence of haemagglutinin and complement-fixing antigen was related to the amount of virus.

Allantoic fluid from infected eggs could be a ready source of antigen for complement-fixation.

Type
Research Article
Information
Journal of Hygiene , Volume 54 , Issue 1 , March 1956 , pp. 114 - 117
Copyright
Copyright © Cambridge University Press 1956

References

REFERENCES

Beveridge, W. I. B. & Burnet, F. M. (1946). The cultivation of viruses and rickettsiae in the chick embryo. Spec. Rep. Ser. med. Res. Coun., Lond., no. 256.Google Scholar
Briody, B. A. & Stannard, C. (1951). Studies on vaccinia virus. I. The development of haemagglutinating and infective particles in the chorio-allantois of the chick embryo. J. Immunol. 67, 403.CrossRefGoogle Scholar
Buddingh, G. J. (1936). A study of generalized vaccinia in the chick embryo. J. exp. Med. 63, 227.CrossRefGoogle ScholarPubMed
Hoagland, C. L., Smadel, J. E. & Rivers, T. M. (1940). Constituents of elementary bodies of vaccinia; certain basic analyses and observations on lipid components of the virus. J. exp. Med. 71, 737.CrossRefGoogle ScholarPubMed
Maitland, H. B. & Tobin, B. M. (1956). The growth of vaccinia virus in the chorio-allantois of the developing chick embryo and the production of complement-fixing antigen and haemagglutinin. J. Hyg., Camb., 54, 102.CrossRefGoogle Scholar
Stone, J. D. & Burnet, F. M. (1946). Production of vaccinia haemagglutinin in rabbit skin. Aust. J. exp. Biol. med. Sci. 24, 9.CrossRefGoogle ScholarPubMed