Hostname: page-component-cd9895bd7-fscjk Total loading time: 0 Render date: 2025-01-03T22:20:21.985Z Has data issue: false hasContentIssue false
  • English
  • Français

Effect of various oral dose levels of a trimethoprim/sulphadiazine mixture on Bordetella bronchiseptica infection and on the proliferation of trimethoprim-resistant faecal coliforms in pigs

Published online by Cambridge University Press:  19 October 2009

L. Dassanayake  and
G. White
L. Dassanayake
Affiliation:
Wellcome Research Laboratories, Berkhamsted Hill, Berkhamsled HP4 2QE
G. White
Affiliation:
Wellcome Research Laboratories, Berkhamsted Hill, Berkhamsled HP4 2QE
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

When a 1:5 mixture of trimethoprim (TMP) and sulphadiazine was fed to pigs intra-nasally infected with Bordetella bronchiseptica, 10 mg/kg/day was shown to be highly effective in suppressing the organism. This dose level had little effect on numbers of TMP-resistant coliforms in faeces, but oral doses of 30 mg/kg/day eventually selected a resistant population. It is suggested that the proliferation of resistant coliforms would be minimized by administration of the lowest oral dose rates of antibacterial drugs compatible with efficacy.

Type
Research Article
Information
Journal of Hygiene , Volume 90 , Issue 1 , February 1983 , pp. 41 - 47
Copyright
Copyright © Cambridge University Press 1983

References

REFERENCES

Datta, N. & Hedges, R. W. (1972). Trimethoprim resistance conferred by W plasmids in Enterobacteriaceae. Journal of General Microbiology 72, 349–355.CrossRefGoogle Scholar
Giles, C. J., Smith, I. M., Baskerville, A. J. & Oliphant, J. (1981). Treatment of experimental Bordetella bronchiseptica infection in young pigs with potentiated sulphonamide in the drinking water. Veterinary Record 108, 136–139.Google Scholar
Joint Committee on the Use of Antibiotics in Animal Husbandry and Veterinary Medicine – Report (1969) H.M.S.O. Cmnd. 4190.Google Scholar
McCandlish, I. A. P. & Thompson, H. (1979). Canine bordetellosis: Chemotherapy using a sulphadiazine–trimethoprim combination. Veterinary Record 105, 51–54.Google Scholar
Rollins, L. D., Gaines, S. A., Pocurull, D. W. & Mercer, H. D. (1975). Animal model for determining the no-effect level of an antimicrobial drug on the drug resistance in the lactose-fermenting enteric flora. Antimicrobial Agents and Chemotherapy 7, 661–665.Google Scholar
Smith, H. Williams & Lovell, M. A. (1981). Escherichia coli resistant to tetracyclines and to other antibiotics in the faeces of U.K. chickens and pigs in 1980. Journal of Hygiene 87, 477–483.Google Scholar