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Elimination of bacteria from dogs with antibiotics*

Published online by Cambridge University Press:  15 May 2009

Norman R. Hayes ,
D. Van Der Waaij  and
Bennett J. Cohen
Norman R. Hayes
Affiliation:
Unit for Laboratory Animal Medicine, University of Michigan, Ann Arbor, Michigan
D. Van Der Waaij
Affiliation:
Unit for Laboratory Animal Medicine, University of Michigan, Ann Arbor, Michigan
Bennett J. Cohen
Affiliation:
Unit for Laboratory Animal Medicine, University of Michigan, Ann Arbor, Michigan
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Summary

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The effect of oral administration of neomycin cephalothin or kanamycin cephalothin on the aerobic intestinal bacterial flora, was studied in dogs maintained under isolation conditions in a conventional animal room. The dogs were successfully freed of aerobic bacteria with both combinations within two to seven days after the start of antibiotic treatment, and were maintained bacteria free for up to 21 days. Decontamination was attained more rapidly in dogs that were bathed in hexachlorophene surgical soap before and during the first and third days of antibiotic treatment. There was no evidence of toxicity from either of the antibiotic combinations. These results indicate that, as with mice and monkeys, decontamination of dogs with oral antibiotics is feasible. The technique is of potential value in preventing endogenous bacterial infections in canine experimental studies involving use of immunosuppressive agents.

Type
Research Article
Information
Journal of Hygiene , Volume 73 , Issue 2 , October 1974 , pp. 205 - 212
Copyright
Copyright © Cambridge University Press 1974

References

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