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The Epidemic Potency of Strains of Bact. aertrycke of varying virulence

Published online by Cambridge University Press:  15 May 2009

W. W. C. Topley ,
M. Geeenwood ,
J. Wilson  and
E. M. Newbold
W. W. C. Topley
Affiliation:
From the London School of Hygiene and Tropical Medicine.
M. Geeenwood
Affiliation:
From the London School of Hygiene and Tropical Medicine.
J. Wilson
Affiliation:
From the London School of Hygiene and Tropical Medicine.
E. M. Newbold
Affiliation:
From the London School of Hygiene and Tropical Medicine.
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Summarising the results obtained in this series of experiments, it would appear that, in the case of Bact. aertrycke infection spreading among a closed community of mice:

(1) The character and severity of the epidemic are mainly determined by the virulence of the infecting bacterial strain.

(2) Strains of high virulence may give rise to non-fatal persistent infections, maintaining their full virulence over long periods of time within the spleens of the infected mice.

(3) Strains of low virulence may persist for long periods of time within such closed populations, spreading to some extent among the mice at risk, causing occasional deaths, and leading to an appreciable number of latent infections.

(4) It would appear that virulence and power to spread are highly corre lated.

Type
Research Article
Information
Journal of Hygiene , Volume 27 , Issue 4 , June 1928 , pp. 396 - 411
Copyright
Copyright © Cambridge University Press 1928

References

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