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Estimate of molecular equivalents of antibody required for prophylaxis and therapy of poliomyelitis

Published online by Cambridge University Press:  15 May 2009

K. M. Stevens
K. M. Stevens
Affiliation:
Merck Institute for Therapeutic Research, West Point, Pennsylvania
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Calculations have been carried out which suggest that as few as 6 × 104 molecules of anti-poliovirus antibody per millilitre of serum may be sufficient to prevent the clinical disease under certain epidemic conditions. Other calculations have been made involving therapy of the experimental disease in monkeys and certain factors required for successful serum therapy have been discussed.

Type
Research Article
Information
Journal of Hygiene , Volume 57 , Issue 2 , June 1959 , pp. 198 - 201
Copyright
Copyright © Cambridge University Press 1959

References

REFERENCES

Bland, J. H. (1956). Disturbances of Body Fluids, 2nd ed. Philadelphia: Saunders.Google Scholar
Burtin, P. & Pocidalo, J. J. (1954). Pr. Méd. 62, 1072.Google Scholar
Colio, L. G., Criley, B. R. & Coriell, L. L. (1958). J. Immunol. 80, 278.CrossRefGoogle Scholar
Dixon, F. J., Talmage, D. W., Maurer, P. H. & Deichmiller, M. (1952). J. exp. Med. 96, 313.CrossRefGoogle Scholar
Fishman, R. A. (1953). Amer. J. Physiol. 175, 96.CrossRefGoogle Scholar
Freund, J. (1930). J. exp. Med. 51, 889.CrossRefGoogle Scholar
Good, R. A. & Zak, S. J. (1956). Pediatrics, 18, 109.CrossRefGoogle Scholar
Hammon, W Mcd., Coriell, L. L., Wehrle, P. F. & Stokes, J. (1953). J. Amer. med. Ass. 151, 1272.Google Scholar
Liu, O. C., Carter, J. E., De Sanctis, A. N., Geating, J. A. & Hampil, B. (1958). J. Immunol. 80, 106.CrossRefGoogle Scholar
Liu, O. C., Carter, J. E., Sanders, B. E., Smith, E. V. C. & Hampil, B. (1959). Brit. J. exp. Path. 40, 133.Google Scholar
Ransom, F. (1900). Z. Physiol. Chem. 31, 282.CrossRefGoogle Scholar
Roboz, E. (1953). Neurology, 3, 410.CrossRefGoogle Scholar
Stevens, K. M. (1957). J. Hyg., Camb., 55, 489.Google Scholar
White, A., Handler, P., Smith, E. L. & Stetten, Dewitt (1954). Principles of Biochemistry. New York: McGraw-Hill.Google Scholar
Youngner, J. S. (1953). Proc. Soc. exp. Biol., N.Y., 84, 697.CrossRefGoogle Scholar